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- W2891870161 abstract "Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia (AML) with distinct morphologic, biologic, and clinical features that can be successfully treated with ATRA-based regimens. APL represents a true emergency due to the high risk of developing life-threatening coagulopathy if untreated promptly. Multiparameter flow cytometry (MFC) has an established role in AML diagnosis and follow-up. In particular for APL, morphology features and a typical immunophenotype are keys for initial screening and to provide a timely diagnosis prior to results of ancillary tests (eg, cytogenetics, FISH, and PCR). A characteristic “APL immunophenotype” displays most of the following features: high side scatter; positivity for CD13 (heterogeneous), CD33 (bright), and CD117 (variable); and absent CD34, CD11, CD10, and HLA-DR. However, some of these features might be absent in APL or present in other types of AML, making the immunological characterization of blasts technically challenging for many cases. We reported three newly diagnosed AML cases with an “APL-like” immunophenotype in this study. In these cases, the blasts showed monocytic differentiation; one of them showed Auer rods. Immunophenotype was investigated by MFC as a routine workup; cytogenetics, FISH, and PCR were also performed. In all three cases, blasts expressed CD33, CD13, and cMPO; an elevated SSC; and a lack of CD34, CD11, and HLA-DR. In two cases, blasts also expressed CD4 and CD117; in the other case, cells partially expressed CD15 and were weakly positive for CD117. Neither t(15;17) nor PML/RARα gene rearrangement were detected (by cytogenetics, FISH, or PCR). NPM1 gene mutation was identified in all cases, and FLT3-ITD mutation was present in two cases. Previous studies have also described NPM-mutated AML with CD34 and HLA-DR negativity. These findings indicate that despite the utility of MFC, cytogenetic and molecular characterizations are necessary to establish accurate diagnosis in AML." @default.
- W2891870161 created "2018-09-27" @default.
- W2891870161 creator A5035002519 @default.
- W2891870161 date "2018-09-21" @default.
- W2891870161 modified "2023-09-25" @default.
- W2891870161 title "Acute Myeloid Leukemia With APL-Like Immunophenotype: A Case Series" @default.
- W2891870161 doi "https://doi.org/10.1093/ajcp/aqy097.268" @default.
- W2891870161 hasPublicationYear "2018" @default.
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