Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891870314> ?p ?o ?g. }
- W2891870314 endingPage "1398" @default.
- W2891870314 startingPage "1388" @default.
- W2891870314 abstract "Structural variants (SVs) can contribute to oncogenesis through a variety of mechanisms. Despite their importance, the identification of SVs in cancer genomes remains challenging. Here, we present a framework that integrates optical mapping, high-throughput chromosome conformation capture (Hi-C), and whole-genome sequencing to systematically detect SVs in a variety of normal or cancer samples and cell lines. We identify the unique strengths of each method and demonstrate that only integrative approaches can comprehensively identify SVs in the genome. By combining Hi-C and optical mapping, we resolve complex SVs and phase multiple SV events to a single haplotype. Furthermore, we observe widespread structural variation events affecting the functions of noncoding sequences, including the deletion of distal regulatory sequences, alteration of DNA replication timing, and the creation of novel three-dimensional chromatin structural domains. Our results indicate that noncoding SVs may be underappreciated mutational drivers in cancer genomes." @default.
- W2891870314 created "2018-09-27" @default.
- W2891870314 creator A5006572717 @default.
- W2891870314 creator A5006847496 @default.
- W2891870314 creator A5012225901 @default.
- W2891870314 creator A5015455225 @default.
- W2891870314 creator A5015742887 @default.
- W2891870314 creator A5019457071 @default.
- W2891870314 creator A5019642844 @default.
- W2891870314 creator A5020541064 @default.
- W2891870314 creator A5024425081 @default.
- W2891870314 creator A5025299677 @default.
- W2891870314 creator A5026324674 @default.
- W2891870314 creator A5026527049 @default.
- W2891870314 creator A5026645386 @default.
- W2891870314 creator A5028208583 @default.
- W2891870314 creator A5029663004 @default.
- W2891870314 creator A5032731901 @default.
- W2891870314 creator A5036074664 @default.
- W2891870314 creator A5036380790 @default.
- W2891870314 creator A5038851202 @default.
- W2891870314 creator A5040435994 @default.
- W2891870314 creator A5040690472 @default.
- W2891870314 creator A5045738356 @default.
- W2891870314 creator A5047645830 @default.
- W2891870314 creator A5051998023 @default.
- W2891870314 creator A5052002555 @default.
- W2891870314 creator A5053398622 @default.
- W2891870314 creator A5056137343 @default.
- W2891870314 creator A5059431543 @default.
- W2891870314 creator A5062993477 @default.
- W2891870314 creator A5069259926 @default.
- W2891870314 creator A5073052023 @default.
- W2891870314 creator A5076505156 @default.
- W2891870314 creator A5076863688 @default.
- W2891870314 creator A5081589298 @default.
- W2891870314 creator A5089566348 @default.
- W2891870314 creator A5089660173 @default.
- W2891870314 date "2018-09-10" @default.
- W2891870314 modified "2023-10-11" @default.
- W2891870314 title "Integrative detection and analysis of structural variation in cancer genomes" @default.
- W2891870314 cites W1605145036 @default.
- W2891870314 cites W1791377616 @default.
- W2891870314 cites W1859117663 @default.
- W2891870314 cites W1941076503 @default.
- W2891870314 cites W1967717472 @default.
- W2891870314 cites W1972660853 @default.
- W2891870314 cites W1973062929 @default.
- W2891870314 cites W1995529519 @default.
- W2891870314 cites W1998593414 @default.
- W2891870314 cites W2006799115 @default.
- W2891870314 cites W2011474502 @default.
- W2891870314 cites W2016661249 @default.
- W2891870314 cites W2037882754 @default.
- W2891870314 cites W2045046980 @default.
- W2891870314 cites W2055402151 @default.
- W2891870314 cites W2057762784 @default.
- W2891870314 cites W2058780460 @default.
- W2891870314 cites W2064469303 @default.
- W2891870314 cites W2073504534 @default.
- W2891870314 cites W2077791115 @default.
- W2891870314 cites W2080477348 @default.
- W2891870314 cites W2083870688 @default.
- W2891870314 cites W2090037139 @default.
- W2891870314 cites W2094243143 @default.
- W2891870314 cites W2096989136 @default.
- W2891870314 cites W2097323692 @default.
- W2891870314 cites W2097627856 @default.
- W2891870314 cites W2097798909 @default.
- W2891870314 cites W2100305481 @default.
- W2891870314 cites W2102140136 @default.
- W2891870314 cites W2102598575 @default.
- W2891870314 cites W2104830962 @default.
- W2891870314 cites W2108698786 @default.
- W2891870314 cites W2111350087 @default.
- W2891870314 cites W2117692326 @default.
- W2891870314 cites W2118151336 @default.
- W2891870314 cites W2118970626 @default.
- W2891870314 cites W2121743948 @default.
- W2891870314 cites W2121948489 @default.
- W2891870314 cites W2127800340 @default.
- W2891870314 cites W2128940246 @default.
- W2891870314 cites W2131898239 @default.
- W2891870314 cites W2132882607 @default.
- W2891870314 cites W2135922376 @default.
- W2891870314 cites W2137279138 @default.
- W2891870314 cites W2139399606 @default.
- W2891870314 cites W2146005104 @default.
- W2891870314 cites W2153120294 @default.
- W2891870314 cites W2153220158 @default.
- W2891870314 cites W2156274673 @default.
- W2891870314 cites W2156509269 @default.
- W2891870314 cites W2156988725 @default.
- W2891870314 cites W2158804744 @default.
- W2891870314 cites W2161535481 @default.
- W2891870314 cites W2162536970 @default.
- W2891870314 cites W2184985920 @default.
- W2891870314 cites W2205690268 @default.