FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891873452> ?p ?o ?g. }

• W2891873452 abstract "The treatment effect in a specific subgroup is often of interest in randomized clinical trials. When the subgroup is characterized by the absence of certain post-randomization events, a naive analysis on the subset of patients without these events may be misleading. The principal stratification framework allows one to define an appropriate causal estimand in such settings. Statistical inference for the principal stratum estimand hinges on scientifically justified assumptions, which can be included with Bayesian methods through prior distributions. Our motivating example is a large randomized placebo-controlled trial of siponimod in patients with secondary progressive multiple sclerosis. The primary objective of this trial was to demonstrate the efficacy of siponimod relative to placebo in delaying disability progression for the whole study population. However, the treatment effect in the subgroup of patients who would not relapse during the trial is relevant from both a scientific and regulatory perspective. Assessing this subgroup treatment effect is challenging as there is strong evidence that siponimod reduces relapses. Aligned with the draft regulatory guidance ICH E9(R1), we describe in detail the scientific question of interest, the principal stratum estimand, the corresponding analysis method for binary endpoints and sensitivity analyses." @default.
• W2891873452 created "2018-09-27" @default.
• W2891873452 creator A5019579195 @default.
• W2891873452 creator A5028193922 @default.
• W2891873452 creator A5046978081 @default.
• W2891873452 creator A5073799553 @default.
• W2891873452 date "2018-09-11" @default.
• W2891873452 modified "2023-09-27" @default.
• W2891873452 title "Bayesian inference for a principal stratum estimand to assess the treatment effect in a subgroup characterized by post-randomization events" @default.
• W2891873452 cites W1490576214 @default.
• W2891873452 cites W2009432182 @default.
• W2891873452 cites W2022439966 @default.
• W2891873452 cites W2045656233 @default.
• W2891873452 cites W2069271851 @default.
• W2891873452 cites W2078110114 @default.
• W2891873452 cites W2090171245 @default.
• W2891873452 cites W2096619033 @default.
• W2891873452 cites W2105309689 @default.
• W2891873452 cites W2127155626 @default.
• W2891873452 cites W2127469535 @default.
• W2891873452 cites W2132917208 @default.
• W2891873452 cites W2138290169 @default.
• W2891873452 cites W2139560482 @default.
• W2891873452 cites W2144512268 @default.
• W2891873452 cites W2156597715 @default.
• W2891873452 cites W2272384778 @default.
• W2891873452 cites W2274134971 @default.
• W2891873452 cites W2340607574 @default.
• W2891873452 cites W2485563171 @default.
• W2891873452 cites W2528786276 @default.
• W2891873452 cites W2577537660 @default.
• W2891873452 cites W2601963095 @default.
• W2891873452 cites W2769000982 @default.
• W2891873452 cites W2790816436 @default.
• W2891873452 cites W2963153709 @default.
• W2891873452 cites W2970567995 @default.
• W2891873452 hasPublicationYear "2018" @default.
• W2891873452 type Work @default.
• W2891873452 sameAs 2891873452 @default.
• W2891873452 citedByCount "0" @default.
• W2891873452 crossrefType "posted-content" @default.
• W2891873452 hasAuthorship W2891873452A5019579195 @default.
• W2891873452 hasAuthorship W2891873452A5028193922 @default.
• W2891873452 hasAuthorship W2891873452A5046978081 @default.
• W2891873452 hasAuthorship W2891873452A5073799553 @default.
• W2891873452 hasConcept C105795698 @default.
• W2891873452 hasConcept C126322002 @default.
• W2891873452 hasConcept C142724271 @default.
• W2891873452 hasConcept C149782125 @default.
• W2891873452 hasConcept C154945302 @default.
• W2891873452 hasConcept C15744967 @default.
• W2891873452 hasConcept C158600405 @default.
• W2891873452 hasConcept C168563851 @default.
• W2891873452 hasConcept C187960798 @default.
• W2891873452 hasConcept C204243189 @default.
• W2891873452 hasConcept C204787440 @default.
• W2891873452 hasConcept C27081682 @default.
• W2891873452 hasConcept C2776214188 @default.
• W2891873452 hasConcept C2908647359 @default.
• W2891873452 hasConcept C2987370644 @default.
• W2891873452 hasConcept C33923547 @default.
• W2891873452 hasConcept C41008148 @default.
• W2891873452 hasConcept C535046627 @default.
• W2891873452 hasConcept C556039675 @default.
• W2891873452 hasConcept C71924100 @default.
• W2891873452 hasConcept C95190672 @default.
• W2891873452 hasConcept C99454951 @default.
• W2891873452 hasConceptScore W2891873452C105795698 @default.
• W2891873452 hasConceptScore W2891873452C126322002 @default.
• W2891873452 hasConceptScore W2891873452C142724271 @default.
• W2891873452 hasConceptScore W2891873452C149782125 @default.
• W2891873452 hasConceptScore W2891873452C154945302 @default.
• W2891873452 hasConceptScore W2891873452C15744967 @default.
• W2891873452 hasConceptScore W2891873452C158600405 @default.
• W2891873452 hasConceptScore W2891873452C168563851 @default.
• W2891873452 hasConceptScore W2891873452C187960798 @default.
• W2891873452 hasConceptScore W2891873452C204243189 @default.
• W2891873452 hasConceptScore W2891873452C204787440 @default.
• W2891873452 hasConceptScore W2891873452C27081682 @default.
• W2891873452 hasConceptScore W2891873452C2776214188 @default.
• W2891873452 hasConceptScore W2891873452C2908647359 @default.
• W2891873452 hasConceptScore W2891873452C2987370644 @default.
• W2891873452 hasConceptScore W2891873452C33923547 @default.
• W2891873452 hasConceptScore W2891873452C41008148 @default.
• W2891873452 hasConceptScore W2891873452C535046627 @default.
• W2891873452 hasConceptScore W2891873452C556039675 @default.
• W2891873452 hasConceptScore W2891873452C71924100 @default.
• W2891873452 hasConceptScore W2891873452C95190672 @default.
• W2891873452 hasConceptScore W2891873452C99454951 @default.
• W2891873452 hasLocation W28918734521 @default.
• W2891873452 hasOpenAccess W2891873452 @default.
• W2891873452 hasPrimaryLocation W28918734521 @default.
• W2891873452 hasRelatedWork W1544545151 @default.
• W2891873452 hasRelatedWork W2073838304 @default.
• W2891873452 hasRelatedWork W2085483280 @default.
• W2891873452 hasRelatedWork W2090323470 @default.
• W2891873452 hasRelatedWork W2117846665 @default.
• W2891873452 hasRelatedWork W2122535549 @default.
• W2891873452 hasRelatedWork W2125244251 @default.
• W2891873452 hasRelatedWork W2139079338 @default.

• next