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• W2891879622 endingPage "e0203781" @default.
• W2891879622 startingPage "e0203781" @default.
• W2891879622 abstract "Notch signaling is conserved in most multicellular organisms and plays critical roles during animal development. The core components and major signal transduction mechanism of Notch signaling have been extensively studied. However, our understanding of how Notch signaling activity is regulated in diverse developmental processes still remains incomplete. Here, we report a genetic mosaic screen in Drosophila melanogaster that leads to identification of Notch signali ng modulators during wing development. We discovered a group of genes required for the formation of the fly wing margin, a developmental process that is strictly dependent on the balanced Notch signaling activity. These genes encode transcription factors, protein phosphatases, vacuolar ATPases and factors required for RNA transport, stability, and translation. Our data support the view that Notch signaling is controlled through a wide range of molecular processes. These results also provide foundations for further study by showing that Me31B and Wdr62 function as two novel modulators of Notch signaling activity." @default.
• W2891879622 created "2018-09-27" @default.
• W2891879622 creator A5000304725 @default.
• W2891879622 creator A5008732302 @default.
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• W2891879622 creator A5041514243 @default.
• W2891879622 creator A5045486164 @default.
• W2891879622 creator A5052738583 @default.
• W2891879622 date "2018-09-20" @default.
• W2891879622 modified "2023-10-09" @default.
• W2891879622 title "A genetic mosaic screen identifies genes modulating Notch signaling in Drosophila" @default.
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• W2891879622 doi "https://doi.org/10.1371/journal.pone.0203781" @default.
• W2891879622 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6147428" @default.
• W2891879622 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30235233" @default.
• W2891879622 hasPublicationYear "2018" @default.

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