FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891882014> ?p ?o ?g. }

• W2891882014 abstract "Genetic and environment factors affect the occurrence and development of coronary artery disease (CAD). Proprotein convertase subtilisin/kexin type 9 (PCSK9), has been investigated extensively in the field of lipid metabolism and CAD. We performed this case-control study to investigate the relationship between serum PCSK9 levels and PCSK9 polymorphisms and lipid levels and CAD risk in a southern Chinese population. A hospital-based case-control study with 1, 096 subjects, including 626 CAD patients and 470 controls, were conducted. Genotyping of PCSK9 polymorphisms was performed using polymerase chain reaction-ligase detection reaction (PCR-LDR) method. The frequencies of the AA, AG and GG genotypes of PCSK9 E670G polymorphism were 90.58, 9.27, and 0.16% in the CAD patients, compared with 88.72, 10.85 and 0.43% in the controls, respectively. No R46L variant was detected in this population. There were no significant differences in genotype and allele frequencies of PCSK9E670G polymorphism between the CAD group and the controls. Serum lipid levels were not significantly different in carriers with the G allele and those with the AA genotype. The median (QR) of PCSK9 concentration was 1205.00 ng/l (577.28–1694.13 ng/l) in cases and 565.87 ng/l (357.17–967.50 ng/l) in controls, respectively. Compared with controls, CAD patients had significantly higher PCSK9 levels (z = 4.559, P < 0.001). After adjusting for age, gender, essential hypertension, diabetic mellitus, smoking and lipid profiles, PCSK9 levels remain significantly associated with increased CAD susceptibility (OR = 1.002, 95% CI = 1.001–1.002, P < 0.001). The correlation analyses showed that serum PCSK9 levels were positively associated with triglyceride (TG), Apo B and atherogenic index of plasma (AIP) levels in controls. No significant association between the PCSK9 E670G polymorphism and serum PCSK9 levels was observed in the CAD group and the controls. The present study shows that serum PCSK9 levels, but not PCSK9 polymorphisms, are associated with CAD risk in Southern Chinese Han population, and that serum PCSK9 levels are positively associated with AIP." @default.
• W2891882014 created "2018-09-27" @default.
• W2891882014 creator A5027475930 @default.
• W2891882014 creator A5046896857 @default.
• W2891882014 creator A5061584676 @default.
• W2891882014 creator A5081618633 @default.
• W2891882014 creator A5086817506 @default.
• W2891882014 date "2018-09-11" @default.
• W2891882014 modified "2023-10-05" @default.
• W2891882014 title "Serum PCSK9 levels, but not PCSK9 polymorphisms, are associated with CAD risk and lipid profiles in southern Chinese Han population" @default.
• W2891882014 cites W1979938630 @default.
• W2891882014 cites W1988720566 @default.
• W2891882014 cites W1991813353 @default.
• W2891882014 cites W1997676317 @default.
• W2891882014 cites W2096119329 @default.
• W2891882014 cites W2136671135 @default.
• W2891882014 cites W2153982977 @default.
• W2891882014 cites W2179697345 @default.
• W2891882014 cites W2233565236 @default.
• W2891882014 cites W2334744705 @default.
• W2891882014 cites W2396510396 @default.
• W2891882014 cites W2509145243 @default.
• W2891882014 cites W2527337325 @default.
• W2891882014 cites W2533289628 @default.
• W2891882014 cites W2606505978 @default.
• W2891882014 cites W2625591229 @default.
• W2891882014 cites W2754220212 @default.
• W2891882014 cites W2762255052 @default.
• W2891882014 cites W2762550541 @default.
• W2891882014 cites W2766392615 @default.
• W2891882014 cites W2794707225 @default.
• W2891882014 cites W2800617506 @default.
• W2891882014 cites W2800755231 @default.
• W2891882014 cites W2800944065 @default.
• W2891882014 cites W2801317041 @default.
• W2891882014 cites W2806174733 @default.
• W2891882014 cites W3024957253 @default.
• W2891882014 doi "https://doi.org/10.1186/s12944-018-0859-5" @default.
• W2891882014 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6134597" @default.
• W2891882014 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30205809" @default.
• W2891882014 hasPublicationYear "2018" @default.
• W2891882014 type Work @default.
• W2891882014 sameAs 2891882014 @default.
• W2891882014 citedByCount "11" @default.
• W2891882014 countsByYear W28918820142019 @default.
• W2891882014 countsByYear W28918820142021 @default.
• W2891882014 countsByYear W28918820142022 @default.
• W2891882014 countsByYear W28918820142023 @default.
• W2891882014 crossrefType "journal-article" @default.
• W2891882014 hasAuthorship W2891882014A5027475930 @default.
• W2891882014 hasAuthorship W2891882014A5046896857 @default.
• W2891882014 hasAuthorship W2891882014A5061584676 @default.
• W2891882014 hasAuthorship W2891882014A5081618633 @default.
• W2891882014 hasAuthorship W2891882014A5086817506 @default.
• W2891882014 hasBestOaLocation W28918820141 @default.
• W2891882014 hasConcept C104317684 @default.
• W2891882014 hasConcept C126322002 @default.
• W2891882014 hasConcept C134018914 @default.
• W2891882014 hasConcept C135763542 @default.
• W2891882014 hasConcept C148257392 @default.
• W2891882014 hasConcept C175239580 @default.
• W2891882014 hasConcept C180754005 @default.
• W2891882014 hasConcept C22894154 @default.
• W2891882014 hasConcept C2778163477 @default.
• W2891882014 hasConcept C2778213512 @default.
• W2891882014 hasConcept C2778270857 @default.
• W2891882014 hasConcept C2780072125 @default.
• W2891882014 hasConcept C2780948078 @default.
• W2891882014 hasConcept C2908647359 @default.
• W2891882014 hasConcept C31467283 @default.
• W2891882014 hasConcept C37463918 @default.
• W2891882014 hasConcept C382228 @default.
• W2891882014 hasConcept C43554185 @default.
• W2891882014 hasConcept C54355233 @default.
• W2891882014 hasConcept C71924100 @default.
• W2891882014 hasConcept C86803240 @default.
• W2891882014 hasConcept C99454951 @default.
• W2891882014 hasConceptScore W2891882014C104317684 @default.
• W2891882014 hasConceptScore W2891882014C126322002 @default.
• W2891882014 hasConceptScore W2891882014C134018914 @default.
• W2891882014 hasConceptScore W2891882014C135763542 @default.
• W2891882014 hasConceptScore W2891882014C148257392 @default.
• W2891882014 hasConceptScore W2891882014C175239580 @default.
• W2891882014 hasConceptScore W2891882014C180754005 @default.
• W2891882014 hasConceptScore W2891882014C22894154 @default.
• W2891882014 hasConceptScore W2891882014C2778163477 @default.
• W2891882014 hasConceptScore W2891882014C2778213512 @default.
• W2891882014 hasConceptScore W2891882014C2778270857 @default.
• W2891882014 hasConceptScore W2891882014C2780072125 @default.
• W2891882014 hasConceptScore W2891882014C2780948078 @default.
• W2891882014 hasConceptScore W2891882014C2908647359 @default.
• W2891882014 hasConceptScore W2891882014C31467283 @default.
• W2891882014 hasConceptScore W2891882014C37463918 @default.
• W2891882014 hasConceptScore W2891882014C382228 @default.
• W2891882014 hasConceptScore W2891882014C43554185 @default.
• W2891882014 hasConceptScore W2891882014C54355233 @default.
• W2891882014 hasConceptScore W2891882014C71924100 @default.
• W2891882014 hasConceptScore W2891882014C86803240 @default.
• W2891882014 hasConceptScore W2891882014C99454951 @default.
• W2891882014 hasIssue "1" @default.

• next