Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891882052> ?p ?o ?g. }
- W2891882052 abstract "In response to external stimuli, naïve B cells proliferate and take on a range of fates important for immunity. How their fate is determined is a topic of much recent research, with candidates including asymmetric cell division, lineage priming, stochastic assignment, and microenvironment instruction. Here we manipulate the generation of plasmablasts from B lymphocytes in vitro by varying CD40 stimulation strength to determine its influence on potential sources of fate control. Using long-term live cell imaging, we directly measure times to differentiate, divide, and die of hundreds of pairs of sibling cells. These data reveal that while the allocation of fates is significantly altered by signal strength, the proportion of siblings identified with asymmetric fates is unchanged. In contrast, we find that plasmablast generation is enhanced by slowing times to divide, which is consistent with a hypothesis of competing timed stochastic fate outcomes. We conclude that this mechanistically simple source of alternative fate regulation is important, and that useful quantitative models of signal integration can be developed based on its principles." @default.
- W2891882052 created "2018-09-27" @default.
- W2891882052 creator A5019232233 @default.
- W2891882052 creator A5042235507 @default.
- W2891882052 creator A5043291271 @default.
- W2891882052 creator A5062450099 @default.
- W2891882052 date "2018-09-10" @default.
- W2891882052 modified "2023-09-26" @default.
- W2891882052 title "Stochastically Timed Competition Between Division and Differentiation Fates Regulates the Transition From B Lymphoblast to Plasma Cell" @default.
- W2891882052 cites W1575299903 @default.
- W2891882052 cites W1681312898 @default.
- W2891882052 cites W1970927301 @default.
- W2891882052 cites W1974467110 @default.
- W2891882052 cites W1974934611 @default.
- W2891882052 cites W1976808796 @default.
- W2891882052 cites W1994500716 @default.
- W2891882052 cites W1996676269 @default.
- W2891882052 cites W2012069333 @default.
- W2891882052 cites W2016175731 @default.
- W2891882052 cites W2031855875 @default.
- W2891882052 cites W2038973062 @default.
- W2891882052 cites W2041598409 @default.
- W2891882052 cites W2046517086 @default.
- W2891882052 cites W2051939070 @default.
- W2891882052 cites W2056255896 @default.
- W2891882052 cites W2056664344 @default.
- W2891882052 cites W2059718955 @default.
- W2891882052 cites W2069784383 @default.
- W2891882052 cites W2070505228 @default.
- W2891882052 cites W2071380288 @default.
- W2891882052 cites W2072359530 @default.
- W2891882052 cites W2076061482 @default.
- W2891882052 cites W2083385452 @default.
- W2891882052 cites W2085149748 @default.
- W2891882052 cites W2086221877 @default.
- W2891882052 cites W2091085026 @default.
- W2891882052 cites W2093626188 @default.
- W2891882052 cites W2096837743 @default.
- W2891882052 cites W2100300374 @default.
- W2891882052 cites W2101974006 @default.
- W2891882052 cites W2115291391 @default.
- W2891882052 cites W2115558707 @default.
- W2891882052 cites W2118944694 @default.
- W2891882052 cites W2121545810 @default.
- W2891882052 cites W2134342374 @default.
- W2891882052 cites W2137157133 @default.
- W2891882052 cites W2137446997 @default.
- W2891882052 cites W2138071207 @default.
- W2891882052 cites W2164528882 @default.
- W2891882052 cites W2167423357 @default.
- W2891882052 cites W2167568565 @default.
- W2891882052 cites W2177432730 @default.
- W2891882052 cites W2205762158 @default.
- W2891882052 cites W2332239663 @default.
- W2891882052 cites W2552726189 @default.
- W2891882052 cites W2592585942 @default.
- W2891882052 cites W2743416243 @default.
- W2891882052 cites W2747263575 @default.
- W2891882052 cites W2781886817 @default.
- W2891882052 cites W2790032333 @default.
- W2891882052 cites W4246504300 @default.
- W2891882052 doi "https://doi.org/10.3389/fimmu.2018.02053" @default.
- W2891882052 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6139340" @default.
- W2891882052 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30250473" @default.
- W2891882052 hasPublicationYear "2018" @default.
- W2891882052 type Work @default.
- W2891882052 sameAs 2891882052 @default.
- W2891882052 citedByCount "19" @default.
- W2891882052 countsByYear W28918820522019 @default.
- W2891882052 countsByYear W28918820522020 @default.
- W2891882052 countsByYear W28918820522021 @default.
- W2891882052 countsByYear W28918820522022 @default.
- W2891882052 countsByYear W28918820522023 @default.
- W2891882052 crossrefType "journal-article" @default.
- W2891882052 hasAuthorship W2891882052A5019232233 @default.
- W2891882052 hasAuthorship W2891882052A5042235507 @default.
- W2891882052 hasAuthorship W2891882052A5043291271 @default.
- W2891882052 hasAuthorship W2891882052A5062450099 @default.
- W2891882052 hasBestOaLocation W28918820521 @default.
- W2891882052 hasConcept C100701293 @default.
- W2891882052 hasConcept C104317684 @default.
- W2891882052 hasConcept C113842279 @default.
- W2891882052 hasConcept C148738053 @default.
- W2891882052 hasConcept C1491633281 @default.
- W2891882052 hasConcept C163952510 @default.
- W2891882052 hasConcept C169760540 @default.
- W2891882052 hasConcept C18903297 @default.
- W2891882052 hasConcept C203014093 @default.
- W2891882052 hasConcept C2776396001 @default.
- W2891882052 hasConcept C2778977658 @default.
- W2891882052 hasConcept C2780007613 @default.
- W2891882052 hasConcept C54355233 @default.
- W2891882052 hasConcept C59822182 @default.
- W2891882052 hasConcept C81444415 @default.
- W2891882052 hasConcept C81885089 @default.
- W2891882052 hasConcept C85813293 @default.
- W2891882052 hasConcept C86339819 @default.
- W2891882052 hasConcept C86803240 @default.
- W2891882052 hasConcept C91306197 @default.
- W2891882052 hasConcept C95444343 @default.