FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891884766> ?p ?o ?g. }

• W2891884766 abstract "Epidemiological data suggests that there are functional links between bronchial asthma and lung carcinogenesis. Bronchial fibroblasts serve a prominent role in the asthmatic process; however, their involvement in lung cancer progression remains unaddressed. To estimate the effect of the asthmatic microenvironment on the invasiveness of lung cancer cells, the present study compared the behavior of human non‑small cell lung cancer A549 cells exposed to the signals from human bronchial fibroblasts (HBFs) derived from non‑asthmatic donors (NA HBFs) and from asthmatic patients (AS HBFs). NA HBFs did not significantly affect A549 motility, whereas AS HBFs and the media conditioned with AS HBF/A549 co‑cultures increased Snail‑1/connexin43 expression and motility of A549 cells. In contrast to NA HBFs, which formed A549‑impenetrable lateral barriers, α‑SMA+ AS HBFs actively infiltrated A549 monolayers and secreted chemotactic factors that arrested A549 cells within AS HBF/A549 contact zone. However, small sub‑populations of A549 cells could release from this arrest and colonize distant regions of AS HBF monolayers. These data indicated that the interactions between lung cancer cells and HBFs in asthmatic bronchi may facilitate the colonization of lung tumors by fibroblasts. It further stabilizes the tumor microenvironment and potentially facilitates collective colonization of novel bronchial loci by cancer cells. Potential mechanistic links between the asthmatic process and lung cancer progression suggest that bronchial asthma should be included in the list of potential prognostic markers for lung cancer therapy." @default.
• W2891884766 created "2018-09-27" @default.
• W2891884766 creator A5000270852 @default.
• W2891884766 creator A5007085592 @default.
• W2891884766 creator A5016189590 @default.
• W2891884766 creator A5025510517 @default.
• W2891884766 creator A5037631130 @default.
• W2891884766 creator A5042016815 @default.
• W2891884766 creator A5045359129 @default.
• W2891884766 date "2018-09-19" @default.
• W2891884766 modified "2023-09-26" @default.
• W2891884766 title "Invasive bronchial fibroblasts derived from asthmatic patients activate lung cancer A549 cells in�vitro" @default.
• W2891884766 cites W1970540044 @default.
• W2891884766 cites W1972228351 @default.
• W2891884766 cites W1983464008 @default.
• W2891884766 cites W2012433310 @default.
• W2891884766 cites W2017946623 @default.
• W2891884766 cites W2022725703 @default.
• W2891884766 cites W2023805473 @default.
• W2891884766 cites W2024964343 @default.
• W2891884766 cites W2050303077 @default.
• W2891884766 cites W2056978251 @default.
• W2891884766 cites W2058276819 @default.
• W2891884766 cites W2062812016 @default.
• W2891884766 cites W2064564379 @default.
• W2891884766 cites W2079347556 @default.
• W2891884766 cites W2080571923 @default.
• W2891884766 cites W2080860848 @default.
• W2891884766 cites W2086283601 @default.
• W2891884766 cites W2087200744 @default.
• W2891884766 cites W2089412258 @default.
• W2891884766 cites W2102528563 @default.
• W2891884766 cites W2118295402 @default.
• W2891884766 cites W2126308773 @default.
• W2891884766 cites W2495797687 @default.
• W2891884766 cites W2514730931 @default.
• W2891884766 cites W2574413260 @default.
• W2891884766 cites W2587816384 @default.
• W2891884766 cites W2594270071 @default.
• W2891884766 cites W2601831068 @default.
• W2891884766 cites W2762514399 @default.
• W2891884766 doi "https://doi.org/10.3892/ol.2018.9462" @default.
• W2891884766 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6202494" @default.
• W2891884766 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30405798" @default.
• W2891884766 hasPublicationYear "2018" @default.
• W2891884766 type Work @default.
• W2891884766 sameAs 2891884766 @default.
• W2891884766 citedByCount "2" @default.
• W2891884766 countsByYear W28918847662020 @default.
• W2891884766 countsByYear W28918847662021 @default.
• W2891884766 crossrefType "journal-article" @default.
• W2891884766 hasAuthorship W2891884766A5000270852 @default.
• W2891884766 hasAuthorship W2891884766A5007085592 @default.
• W2891884766 hasAuthorship W2891884766A5016189590 @default.
• W2891884766 hasAuthorship W2891884766A5025510517 @default.
• W2891884766 hasAuthorship W2891884766A5037631130 @default.
• W2891884766 hasAuthorship W2891884766A5042016815 @default.
• W2891884766 hasAuthorship W2891884766A5045359129 @default.
• W2891884766 hasBestOaLocation W28918847661 @default.
• W2891884766 hasConcept C121608353 @default.
• W2891884766 hasConcept C126322002 @default.
• W2891884766 hasConcept C142724271 @default.
• W2891884766 hasConcept C170493617 @default.
• W2891884766 hasConcept C203014093 @default.
• W2891884766 hasConcept C2776256026 @default.
• W2891884766 hasConcept C2777714996 @default.
• W2891884766 hasConcept C502942594 @default.
• W2891884766 hasConcept C54166955 @default.
• W2891884766 hasConcept C555283112 @default.
• W2891884766 hasConcept C71924100 @default.
• W2891884766 hasConcept C81729549 @default.
• W2891884766 hasConcept C86803240 @default.
• W2891884766 hasConceptScore W2891884766C121608353 @default.
• W2891884766 hasConceptScore W2891884766C126322002 @default.
• W2891884766 hasConceptScore W2891884766C142724271 @default.
• W2891884766 hasConceptScore W2891884766C170493617 @default.
• W2891884766 hasConceptScore W2891884766C203014093 @default.
• W2891884766 hasConceptScore W2891884766C2776256026 @default.
• W2891884766 hasConceptScore W2891884766C2777714996 @default.
• W2891884766 hasConceptScore W2891884766C502942594 @default.
• W2891884766 hasConceptScore W2891884766C54166955 @default.
• W2891884766 hasConceptScore W2891884766C555283112 @default.
• W2891884766 hasConceptScore W2891884766C71924100 @default.
• W2891884766 hasConceptScore W2891884766C81729549 @default.
• W2891884766 hasConceptScore W2891884766C86803240 @default.
• W2891884766 hasLocation W28918847661 @default.
• W2891884766 hasLocation W28918847662 @default.
• W2891884766 hasLocation W28918847663 @default.
• W2891884766 hasLocation W28918847664 @default.
• W2891884766 hasLocation W28918847665 @default.
• W2891884766 hasOpenAccess W2891884766 @default.
• W2891884766 hasPrimaryLocation W28918847661 @default.
• W2891884766 hasRelatedWork W1930767791 @default.
• W2891884766 hasRelatedWork W2056966621 @default.
• W2891884766 hasRelatedWork W2069273774 @default.
• W2891884766 hasRelatedWork W2116762030 @default.
• W2891884766 hasRelatedWork W2271907559 @default.
• W2891884766 hasRelatedWork W2560940732 @default.
• W2891884766 hasRelatedWork W2769390123 @default.
• W2891884766 hasRelatedWork W2791262225 @default.

• next