Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891885392> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W2891885392 abstract "Abstract Background Multimodality treatment of patients with esophageal adenocarcinoma (EAC) improve survival, but the optimal treatment strategy remains undetermined. The aim of this study was to compare outcomes in patients undergoing neoadjuvant chemotherapy (nCT) and neoadjuvant chemoradiotherapy (nCRT) for EAC. Methods Patients who underwent nCT or nCRT followed by surgery for EAC were identified from a prospective database (2000–2017) and included in this study. After propensity score matching, we compared the impact of the treatments on postoperative complications, in-hospital mortality, pathological outcomes and survival rates. Results Of the 396 eligible patients, 262 patients were analysed following propensity score matching. This resulted in 131 patients in the nCT group versus 131 patients in the nCRT group. There were no significant differences between the nCT and nCRT groups for overall complications (59% vs 57%, P = 0.802) or in-hospital mortality (2% vs 0%, P = 0.156). Patients who had nCRT had more R0 resections (93% vs. 83%, P = 0.013), and a higher pathological complete response rate (15% vs. 5%, P < 0.001). The pattern of recurrence was similar (P = 0.753) and there were no differences in 5-year disease-free survival rates (nCT vs nCRT; 39% vs 39%, P = 0.879) or 5-year overall survival rates (nCT vs nCRT; 44% vs 33%, P = 0.645). Conclusion In this study no differences between nCT and nCRT were seen in postoperative complications and in-hospital mortality in patients treated for EAC. Inspite of improved complete resection and pathological response there was no difference in the overall survival between the treatment modalities. Disclosure All authors have declared no conflicts of interest." @default.
- W2891885392 created "2018-09-27" @default.
- W2891885392 creator A5005797468 @default.
- W2891885392 creator A5012333085 @default.
- W2891885392 creator A5026629483 @default.
- W2891885392 creator A5034443626 @default.
- W2891885392 creator A5045281711 @default.
- W2891885392 creator A5055369142 @default.
- W2891885392 creator A5056736042 @default.
- W2891885392 creator A5068690561 @default.
- W2891885392 creator A5071857504 @default.
- W2891885392 creator A5074100708 @default.
- W2891885392 creator A5078484307 @default.
- W2891885392 creator A5080176242 @default.
- W2891885392 date "2018-09-01" @default.
- W2891885392 modified "2023-09-23" @default.
- W2891885392 title "FA03.05: NEOADJUVANT CHEMOTHERAPY OR CHEMORADIOTHERAPY FOR ADENOCARCINOMA OF THE ESOPHAGUS" @default.
- W2891885392 doi "https://doi.org/10.1093/dote/doy089.fa03.05" @default.
- W2891885392 hasPublicationYear "2018" @default.
- W2891885392 type Work @default.
- W2891885392 sameAs 2891885392 @default.
- W2891885392 citedByCount "0" @default.
- W2891885392 crossrefType "journal-article" @default.
- W2891885392 hasAuthorship W2891885392A5005797468 @default.
- W2891885392 hasAuthorship W2891885392A5012333085 @default.
- W2891885392 hasAuthorship W2891885392A5026629483 @default.
- W2891885392 hasAuthorship W2891885392A5034443626 @default.
- W2891885392 hasAuthorship W2891885392A5045281711 @default.
- W2891885392 hasAuthorship W2891885392A5055369142 @default.
- W2891885392 hasAuthorship W2891885392A5056736042 @default.
- W2891885392 hasAuthorship W2891885392A5068690561 @default.
- W2891885392 hasAuthorship W2891885392A5071857504 @default.
- W2891885392 hasAuthorship W2891885392A5074100708 @default.
- W2891885392 hasAuthorship W2891885392A5078484307 @default.
- W2891885392 hasAuthorship W2891885392A5080176242 @default.
- W2891885392 hasConcept C121608353 @default.
- W2891885392 hasConcept C126322002 @default.
- W2891885392 hasConcept C143998085 @default.
- W2891885392 hasConcept C2776694085 @default.
- W2891885392 hasConcept C2777819096 @default.
- W2891885392 hasConcept C2778424827 @default.
- W2891885392 hasConcept C2781182431 @default.
- W2891885392 hasConcept C2992824209 @default.
- W2891885392 hasConcept C61434518 @default.
- W2891885392 hasConcept C71924100 @default.
- W2891885392 hasConceptScore W2891885392C121608353 @default.
- W2891885392 hasConceptScore W2891885392C126322002 @default.
- W2891885392 hasConceptScore W2891885392C143998085 @default.
- W2891885392 hasConceptScore W2891885392C2776694085 @default.
- W2891885392 hasConceptScore W2891885392C2777819096 @default.
- W2891885392 hasConceptScore W2891885392C2778424827 @default.
- W2891885392 hasConceptScore W2891885392C2781182431 @default.
- W2891885392 hasConceptScore W2891885392C2992824209 @default.
- W2891885392 hasConceptScore W2891885392C61434518 @default.
- W2891885392 hasConceptScore W2891885392C71924100 @default.
- W2891885392 hasLocation W28918853921 @default.
- W2891885392 hasOpenAccess W2891885392 @default.
- W2891885392 hasPrimaryLocation W28918853921 @default.
- W2891885392 isParatext "false" @default.
- W2891885392 isRetracted "false" @default.
- W2891885392 magId "2891885392" @default.
- W2891885392 workType "article" @default.