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• W2891886306 abstract "Despite the various roles of type I interferon (type I IFN) responses during bacterial infection, its specific effects in vivo have been poorly characterized in scrub typhus caused by Orientia tsutsugamushi infection. Here, we show that type I IFNs are primarily induced via intracellular nucleic acids sensors, including RIG-I/MAVS and cGAS/STING pathways, during O. tsutsugamushi invasion. However, type I IFN signaling did not significantly affect pathogenesis, mortality, or bacterial burden during primary infection in vivo, when assessed in a mice model lacking a receptor for type I IFNs (IFNAR KO). Rather, it significantly impaired the induction of antigen-specific T cells and reduced memory T cell responses. IFNAR KO mice that recovered from primary infection showed stronger antigen-specific T cell responses, especially Th1, and more efficiently controlled bacteremia during secondary infection than wild type mice. Enhanced IL-10 expression by macrophages in the presence of type I IFN signaling might play a significant role in the suppression of antigen-specific T cell responses as neutralization or knock-out (KO) of IL-10 increased T cell responses in vitro. Therefore, induction of the type I IFN/IL-10 axis by O. tsutsugamushi infection might play a significant role in the suppression of T cell responses and contribute to the short longevity of cell-mediated immunity, often observed in scrub typhus patients." @default.
• W2891886306 created "2018-09-27" @default.
• W2891886306 creator A5005534381 @default.
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• W2891886306 date "2018-09-04" @default.
• W2891886306 modified "2023-10-14" @default.
• W2891886306 title "A Type I Interferon and IL-10 Induced by Orientia tsutsugamushi Infection Suppresses Antigen-Specific T Cells and Their Memory Responses" @default.
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• W2891886306 doi "https://doi.org/10.3389/fimmu.2018.02022" @default.
• W2891886306 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6131522" @default.
• W2891886306 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30233599" @default.
• W2891886306 hasPublicationYear "2018" @default.
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