Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891887862> ?p ?o ?g. }
- W2891887862 abstract "Abstract Gut-draining mesenteric lymph nodes (mLNs) are important for inducing peripheral tolerance towards food and commensal antigens by providing an optimal microenvironment for de novo generation of Foxp3 + regulatory T cells (Tregs). We previously identified microbiota-imprinted mLN stromal cells as a critical component in tolerance induction. Here we show that this imprinting process already takes place in the neonatal phase, and renders the mLN stromal cell compartment resistant to inflammatory perturbations later in life. LN transplantation and single-cell RNA-seq uncover stably imprinted expression signatures in mLN fibroblastic stromal cells. Subsetting common stromal cells across gut-draining mLNs and skin-draining LNs further refine their location-specific immunomodulatory functions, such as subset-specific expression of Aldh1a2/3 . Finally, we demonstrate that mLN stromal cells shape resident dendritic cells to attain high Treg-inducing capacity in a Bmp2-dependent manner. Thus, crosstalk between mLN stromal and resident dendritic cells provides a robust regulatory mechanism for the maintenance of intestinal tolerance." @default.
- W2891887862 created "2018-09-27" @default.
- W2891887862 creator A5006524527 @default.
- W2891887862 creator A5007802405 @default.
- W2891887862 creator A5017796105 @default.
- W2891887862 creator A5022889337 @default.
- W2891887862 creator A5022986918 @default.
- W2891887862 creator A5027219705 @default.
- W2891887862 creator A5028091273 @default.
- W2891887862 creator A5031460147 @default.
- W2891887862 creator A5032424876 @default.
- W2891887862 creator A5032478236 @default.
- W2891887862 creator A5033698619 @default.
- W2891887862 creator A5036467945 @default.
- W2891887862 creator A5045266621 @default.
- W2891887862 creator A5045522929 @default.
- W2891887862 creator A5047923760 @default.
- W2891887862 creator A5050661448 @default.
- W2891887862 creator A5052391254 @default.
- W2891887862 creator A5054621769 @default.
- W2891887862 creator A5055311133 @default.
- W2891887862 creator A5078759067 @default.
- W2891887862 creator A5083429758 @default.
- W2891887862 creator A5086645239 @default.
- W2891887862 creator A5090061048 @default.
- W2891887862 date "2018-09-25" @default.
- W2891887862 modified "2023-10-13" @default.
- W2891887862 title "Neonatally imprinted stromal cell subsets induce tolerogenic dendritic cells in mesenteric lymph nodes" @default.
- W2891887862 cites W1123491438 @default.
- W2891887862 cites W1592500890 @default.
- W2891887862 cites W1845975704 @default.
- W2891887862 cites W1960895270 @default.
- W2891887862 cites W1972270863 @default.
- W2891887862 cites W1977665068 @default.
- W2891887862 cites W1980237413 @default.
- W2891887862 cites W1986660413 @default.
- W2891887862 cites W1997774819 @default.
- W2891887862 cites W1999906527 @default.
- W2891887862 cites W2003342633 @default.
- W2891887862 cites W2016252333 @default.
- W2891887862 cites W2022274859 @default.
- W2891887862 cites W2032056606 @default.
- W2891887862 cites W2034027385 @default.
- W2891887862 cites W2036334866 @default.
- W2891887862 cites W2036392573 @default.
- W2891887862 cites W2036589586 @default.
- W2891887862 cites W2043659905 @default.
- W2891887862 cites W2046752806 @default.
- W2891887862 cites W2048378882 @default.
- W2891887862 cites W2048659881 @default.
- W2891887862 cites W2049383028 @default.
- W2891887862 cites W2052969143 @default.
- W2891887862 cites W2056279562 @default.
- W2891887862 cites W2057184153 @default.
- W2891887862 cites W2066177626 @default.
- W2891887862 cites W2072853625 @default.
- W2891887862 cites W2073290778 @default.
- W2891887862 cites W2095576941 @default.
- W2891887862 cites W2101014100 @default.
- W2891887862 cites W2102025568 @default.
- W2891887862 cites W2103144700 @default.
- W2891887862 cites W2104135721 @default.
- W2891887862 cites W2105787447 @default.
- W2891887862 cites W2110957620 @default.
- W2891887862 cites W2113594480 @default.
- W2891887862 cites W2114176654 @default.
- W2891887862 cites W2114675972 @default.
- W2891887862 cites W2121833260 @default.
- W2891887862 cites W2123602250 @default.
- W2891887862 cites W2133019048 @default.
- W2891887862 cites W2133809662 @default.
- W2891887862 cites W2134526812 @default.
- W2891887862 cites W2140729960 @default.
- W2891887862 cites W2143196592 @default.
- W2891887862 cites W2144836936 @default.
- W2891887862 cites W2151159165 @default.
- W2891887862 cites W2151350595 @default.
- W2891887862 cites W2160458616 @default.
- W2891887862 cites W2169456326 @default.
- W2891887862 cites W2179438025 @default.
- W2891887862 cites W2292041691 @default.
- W2891887862 cites W2334209689 @default.
- W2891887862 cites W2342278399 @default.
- W2891887862 cites W2470185571 @default.
- W2891887862 cites W2510595980 @default.
- W2891887862 cites W2523819450 @default.
- W2891887862 cites W2545974669 @default.
- W2891887862 cites W2560298068 @default.
- W2891887862 cites W2572662684 @default.
- W2891887862 cites W2588542020 @default.
- W2891887862 cites W2607156097 @default.
- W2891887862 cites W2771767991 @default.
- W2891887862 cites W2794480084 @default.
- W2891887862 cites W2796170779 @default.
- W2891887862 cites W2801762127 @default.
- W2891887862 cites W2951506174 @default.
- W2891887862 doi "https://doi.org/10.1038/s41467-018-06423-7" @default.
- W2891887862 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6156403" @default.
- W2891887862 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30254319" @default.
- W2891887862 hasPublicationYear "2018" @default.