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• W2891887912 startingPage "39" @default.
• W2891887912 abstract "The interactions of the Alzheimer’s β-amyloid peptide, Aβ(25–35), with 18:1 (Δ9-Cis) PC 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC), L-α-phosphatidylcholine (EPC), 1,2-dioleoyl-sn-glycero-3-phospho-(1′-rac-glycerol) (sodium salt) (DOPG), and L-α-phosphatidylglycerol (EPG) phospholipid vesicles with and without cholesterol (Ch) are studied by the nitroxide spin probe electron paramagnetic resonance (EPR) method. Two nitroxide spin probes, 2,2,6,6-tetramethyl-piperidin-1-oxyl-4-yl hexadecanoate (TP, TEMPO-Palmitate) and 2-Ethyl-2-(15-methoxy-15-oxopentadecyl)-4,4-dimethyl-3-oxazolidinyloxy (16-DSE), are utilized in the study. TEMPO-Palmitate has the reporting EPR moiety located at the top of this spin probe, while 16-DSE has the reporting EPR moiety located at the tail of the spin probe. These two probes enable us to sample the surface and the middle of the phospholipid bilayer, respectively. All EPR measurements are done above the melting points of all four phospholipids when the bilayer is in the liquid crystal phase, the physiologically relevant phase. Due to non-linear spectral line fitting, the EPR spectral parameters are extracted with high precision. The results show that there are two populations of Aβ(25–35) and that one of them is located in the hydrophobic phospholipid layer below the hydrophilic headgroup region. The second population appears to be weakly coupled to the surface of the bilayer. Both hydrophobic and electrostatic interactions affect the insertion of Aβ(25–35) in the bilayer. Also, there is strong evidence for an interaction between cholesterol and Aβ(25–35), which affects the dielectric and dynamic properties of the bilayer." @default.
• W2891887912 created "2018-09-27" @default.
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• W2891887912 date "2018-11-01" @default.
• W2891887912 modified "2023-09-24" @default.
• W2891887912 title "Interaction of the β amyloid – Aβ(25–35) – peptide with zwitterionic and negatively charged vesicles with and without cholesterol" @default.
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• W2891887912 doi "https://doi.org/10.1016/j.chemphyslip.2018.09.006" @default.
• W2891887912 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6342288" @default.
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