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- W2891888829 abstract "Membrane fusion of the ER is catalyzed when atlastin GTPases anchored in opposing membranes dimerize and undergo a crossed over conformational rearrangement that draws the bilayers together. Previous studies have suggested that GTP hydrolysis triggers crossover dimerization, thus directly driving fusion. In this study, we make the surprising observations that WT atlastin undergoes crossover dimerization before hydrolyzing GTP and that nucleotide hydrolysis and Pi release coincide more closely with dimer disassembly. These findings suggest that GTP binding, rather than its hydrolysis, triggers crossover dimerization for fusion. In support, a new hydrolysis-deficient atlastin variant undergoes rapid GTP-dependent crossover dimerization and catalyzes fusion at an initial rate similar to WT atlastin. However, the variant cannot sustain fusion activity over time, implying a defect in subunit recycling. We suggest that GTP binding induces an atlastin conformational change that favors crossover dimerization for fusion and that the input of energy from nucleotide hydrolysis promotes complex disassembly for subunit recycling." @default.
- W2891888829 created "2018-09-27" @default.
- W2891888829 creator A5000308991 @default.
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- W2891888829 date "2018-09-24" @default.
- W2891888829 modified "2023-10-14" @default.
- W2891888829 title "GTP hydrolysis promotes disassembly of the atlastin crossover dimer during ER fusion" @default.
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- W2891888829 doi "https://doi.org/10.1083/jcb.201805039" @default.
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