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- W2891889849 abstract "Abstract Rhinitis can be subdivided into three main phenotypes based on history and clinical examination: allergic rhinitis (AR), infectious rhinitis (IR), and nonallergic noninfectious rhinitis (NAR). Different treatment approaches need to be considered given the different etiology of the rhinitis phenotypes. Four pathophysiological mechanisms have been identified as key drivers of the disease: Th1 inflammatory type, Th2 inflammatory type, neurogenic type, and epithelial endotype. The Th2 inflammatory type is predominantly seen in AR patients, whereas the Th1 inflammatory type is mainly found patients with infectious rhinitis. The neurogenic type has been associated with nonallergic rhinitis. Epithelial dysfunction has been demonstrated in AR patients. In real-life, patients might have different endotypes causing rhinitis symptoms, hence making their identification by the use of biomarkers crucial in order to move toward an endotype-driven treatment approach." @default.
- W2891889849 created "2018-09-27" @default.
- W2891889849 creator A5026910751 @default.
- W2891889849 date "2019-01-01" @default.
- W2891889849 modified "2023-09-25" @default.
- W2891889849 title "Endotype-Driven Approach in Rhinitis" @default.
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- W2891889849 doi "https://doi.org/10.1016/b978-0-12-813471-9.00012-8" @default.
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