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• W2891890395 abstract "The two paralogs of the calcium-dependent activator protein for secretion (CAPS) are priming factors for synaptic vesicles and neuropeptide containing large dense-core vesicles (LDCVs). Yet, it is unclear whether CAPS1 and CAPS2 regulate exocytosis of these two vesicles types differentially in dorsal root ganglion (DRG) neurons, wherein synaptic transmission and neuropeptide release are of equal importance. These sensory neurons transfer information from the periphery to the spinal cord, releasing glutamate as the primary neurotransmitter, with co-transmission via neuropeptides in a subset of so called peptidergic neurons. Neuropeptides are key components of the information-processing machinery of pain perception and neuropathic pain generation. Here, we compared the ability of CAPS1 and CAPS2 to support priming of both vesicle types in single and double knock-out mouse (DRG) neurons using a variety of high-resolution live imaging methods. While CAPS1 was localized to synapses of all DRG neurons and promoted synaptic transmission, CAPS2 was found exclusively in peptidergic neurons and mediated LDCV exocytosis. Intriguingly, ectopic expression of CAPS2 empowered non-peptidergic neurons to drive LDCV fusion, thereby identifying CAPS2 as an essential molecular determinant for peptidergic signaling. Our results reveal that these distinct functions of both CAPS paralogs are based on their differential subcellular localization in DRG neurons. Our data suggest a major role for CAPS2 in neuropathic pain via control of neuropeptide release." @default.
• W2891890395 created "2018-09-27" @default.
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• W2891890395 date "2018-09-11" @default.
• W2891890395 modified "2023-09-26" @default.
• W2891890395 title "Paralogs of the Calcium-Dependent Activator Protein for Secretion Differentially Regulate Synaptic Transmission and Peptide Secretion in Sensory Neurons" @default.
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• W2891890395 doi "https://doi.org/10.3389/fncel.2018.00304" @default.
• W2891890395 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6141663" @default.
• W2891890395 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30254567" @default.
• W2891890395 hasPublicationYear "2018" @default.
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