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- W2891891790 abstract "Many tumors exhibit altered metabolic characteristics relative to normal and healthy tissues. Their metabolic profile highlights a strong prevalence of glycolysis over oxidative phosphorylation, regardless of their exposure to different oxygen levels (the Warburg effect). This condition originates from a set of gene regulations, consisting of the overexpression of some enzymes or transporters involved in the glycolytic pathway. Therefore, these effectors may constitute appealing targets for the implementation of selective therapeutic interventions against cancer. Recently, significant progress has been made in the discovery of molecules that act at various levels of the glycolytic pathway of tumor cells. So far, some of the most widely explored targets of the glycolytic cascade are represented by glucose transporters, hexokinase, 6-phosphofructokinase, enolase, pyruvate kinase, lactate dehydrogenase, and monocarboxylate transporters. The purpose of this minireview is to provide an update on some of the most recently patented bioactive molecules that are able to interfere with cancer glycolysis, and on their use in specific combination therapies." @default.
- W2891891790 created "2018-09-27" @default.
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- W2891891790 date "2018-10-09" @default.
- W2891891790 modified "2023-10-17" @default.
- W2891891790 title "An Update on Patents Covering Agents That Interfere with the Cancer Glycolytic Cascade" @default.
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- W2891891790 doi "https://doi.org/10.1002/cmdc.201800447" @default.
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