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- W2891892955 abstract "<p>The aim of this meta-analysis was to systematically evaluate the efficacy and safety of novel oral anticoagulants and vitamin K antagonists in the treatment of venous thromboembolism. A total of 6 studies met the inclusion criteria and a total of 19,350 patients with venous thromboembolism were included. Among them, rivaroxaban (3 RCTs, n=90/3,449/4,832); dabigatran (2 RCTs, n=200/2,539); edoxaban (1 RCT, n=8,240). The results of meta-analysis showed that the total bleeding rate after treatment with the vitamin K antagonist group was higher than with the new oral anticoagulant group (OR=0.82, 95% confidence interval 0.75-0.90, p<0.0001), and the difference was highly statistically significant. Overall, new oral anticoagulants are compara-ble to vitamin K antagonists, but new oral anticoagulants can reduce the occurrence of bleeding events and the safety was superior to vitamin K antagonists.</p>" @default.
- W2891892955 created "2018-09-27" @default.
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- W2891892955 date "2018-09-14" @default.
- W2891892955 modified "2023-09-28" @default.
- W2891892955 title "Efficacy and safety of novel oral anticoagulants versus vitamin K antagonists in the treatment of venous thromboembolism" @default.
- W2891892955 doi "https://doi.org/10.3329/bjp.v13i3.37124" @default.
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