Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891894625> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2891894625 endingPage "e16053" @default.
- W2891894625 startingPage "e16053" @default.
- W2891894625 abstract "e16053 Background: Patients with mediastinal nonseminomatous germ cell tumors belong to poor prognostic group by IGCCCG. Mediastinal seminoma is very rare disease and data of the prognosis and chemotherapy efficacy are scarce. We retrospectively studied the outcome and prognostic factors of patients with mediastinal seminoma. Methods: We analyzed data of 39 (7.9%) patients with mediastinal seminoma from 493 patients with metastatic morphological verified pure seminoma and with normal AFP level and β-hCG < 500 mIU/ml, who were treated in our department during 1986-2014. Median age was 30 years (range: 15-64). All patients had good prognosis according IGCCCG. Medians β-hCG and LDH levels were 15 (range: 0.1-500) and 454 U/l (upper limit of normal is 450 U/l; range 120-2455), respectively. Metastasis were seen in 11/39 (28.2%) patients. Median follow-up time was 33.5 months (range 2-291). All patients were initially treated with chemotherapy; BEP/EP - 31/39 (79.5%), VAB6 or CP (cyclophosphamide/cisplatin) – 8/39 (20.5%) patients. Only 9/39 (23%) patients received < 4cycles of chemotherapy. Surgery resection of residual tumor was performed in 1/39 (2.6%) patient (histological report – necrosis). Statistical analyses was performed using Statistical Package for the Social Sciences Version 22.0 (SPSS Inc., Chicago, IL). Results: Marker negative objective response was revealed in 100% patients: complete response – in 9/39 (23%), partial response - 30/39 (77%) patients. A relapse (2.5%) occurred 12 years after the treatment. That patient was saved with salvage chemotherapy. One patient died from cardiac disease 9 years following chemotherapy. Three-year PFS and OS were 100%. Level of β-hCG (p = 0.4), LDH (p = 0.5), age (p = 0.9), number of cycles of chemotherapy (4 vs 2-3) (p = 0.6) did not alter the PFS. In addition, the scheme of regimen (EP vs BEP) did not influence on PFS – all cases are censured. Conclusions: Patients with mediastinal seminoma have an excellent prognosis in contrast to patients with mediastinal nonseminomatous germ cell tumors. Low number of relapses precluded analysis of prognostic factors." @default.
- W2891894625 created "2018-09-27" @default.
- W2891894625 creator A5012700479 @default.
- W2891894625 creator A5015029111 @default.
- W2891894625 creator A5043371906 @default.
- W2891894625 creator A5044713725 @default.
- W2891894625 creator A5052686564 @default.
- W2891894625 creator A5056407392 @default.
- W2891894625 creator A5056439371 @default.
- W2891894625 creator A5059408969 @default.
- W2891894625 creator A5063215262 @default.
- W2891894625 date "2016-05-20" @default.
- W2891894625 modified "2023-09-27" @default.
- W2891894625 title "Chemotherapy efficacy and prognosis of patients with mediastinal seminoma. Single institution experience." @default.
- W2891894625 doi "https://doi.org/10.1200/jco.2016.34.15_suppl.e16053" @default.
- W2891894625 hasPublicationYear "2016" @default.
- W2891894625 type Work @default.
- W2891894625 sameAs 2891894625 @default.
- W2891894625 citedByCount "0" @default.
- W2891894625 crossrefType "journal-article" @default.
- W2891894625 hasAuthorship W2891894625A5012700479 @default.
- W2891894625 hasAuthorship W2891894625A5015029111 @default.
- W2891894625 hasAuthorship W2891894625A5043371906 @default.
- W2891894625 hasAuthorship W2891894625A5044713725 @default.
- W2891894625 hasAuthorship W2891894625A5052686564 @default.
- W2891894625 hasAuthorship W2891894625A5056407392 @default.
- W2891894625 hasAuthorship W2891894625A5056439371 @default.
- W2891894625 hasAuthorship W2891894625A5059408969 @default.
- W2891894625 hasAuthorship W2891894625A5063215262 @default.
- W2891894625 hasConcept C126322002 @default.
- W2891894625 hasConcept C141071460 @default.
- W2891894625 hasConcept C143998085 @default.
- W2891894625 hasConcept C146357865 @default.
- W2891894625 hasConcept C151730666 @default.
- W2891894625 hasConcept C2776694085 @default.
- W2891894625 hasConcept C2776755627 @default.
- W2891894625 hasConcept C2776938808 @default.
- W2891894625 hasConcept C2778074268 @default.
- W2891894625 hasConcept C2779429289 @default.
- W2891894625 hasConcept C71924100 @default.
- W2891894625 hasConcept C86803240 @default.
- W2891894625 hasConcept C90924648 @default.
- W2891894625 hasConceptScore W2891894625C126322002 @default.
- W2891894625 hasConceptScore W2891894625C141071460 @default.
- W2891894625 hasConceptScore W2891894625C143998085 @default.
- W2891894625 hasConceptScore W2891894625C146357865 @default.
- W2891894625 hasConceptScore W2891894625C151730666 @default.
- W2891894625 hasConceptScore W2891894625C2776694085 @default.
- W2891894625 hasConceptScore W2891894625C2776755627 @default.
- W2891894625 hasConceptScore W2891894625C2776938808 @default.
- W2891894625 hasConceptScore W2891894625C2778074268 @default.
- W2891894625 hasConceptScore W2891894625C2779429289 @default.
- W2891894625 hasConceptScore W2891894625C71924100 @default.
- W2891894625 hasConceptScore W2891894625C86803240 @default.
- W2891894625 hasConceptScore W2891894625C90924648 @default.
- W2891894625 hasIssue "15_suppl" @default.
- W2891894625 hasLocation W28918946251 @default.
- W2891894625 hasOpenAccess W2891894625 @default.
- W2891894625 hasPrimaryLocation W28918946251 @default.
- W2891894625 hasRelatedWork W1546034137 @default.
- W2891894625 hasRelatedWork W2142316271 @default.
- W2891894625 hasRelatedWork W2175965103 @default.
- W2891894625 hasRelatedWork W2353852117 @default.
- W2891894625 hasRelatedWork W2403331838 @default.
- W2891894625 hasRelatedWork W2412245030 @default.
- W2891894625 hasRelatedWork W2416971001 @default.
- W2891894625 hasRelatedWork W4236902267 @default.
- W2891894625 hasRelatedWork W4289968232 @default.
- W2891894625 hasRelatedWork W2189573107 @default.
- W2891894625 hasVolume "34" @default.
- W2891894625 isParatext "false" @default.
- W2891894625 isRetracted "false" @default.
- W2891894625 magId "2891894625" @default.
- W2891894625 workType "article" @default.