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- W2891894713 abstract "e15548 Background: HER2 status is a predictive biomarker to response to trastuzumab in metastatic adenocarcinomas of the stomach our gastroesophageal junction. However, relatively little is known about the role of HER2 in the non-metastatic disease in western population. Methods: This study included 106 patients with gastric cancer who underwent surgery between January 2007 and June 2014 at Universitary Hospital of Santiago de Compostela. Immunohistochemical expression of HER2 was analyzed using the DAKO-HercepTest™ and gene amplification using DAKO-DuoCISH kit; both was scored according to published reports. Correlations between HER2 status, clinicopathological characteristics, survival and relapse sites were retrospective analyzed. Results: HER2 expression rate by IHC was: 76 patients (71.7%) classificated as negative, 7 patients (6.6%) as positive and 23 patients (21.7%) as equivocal. HER2 gene amplification by DuoCISH was positive in 14 patients (13.2%). HER2 status was associated with intestinal subtype (p = 0.010), tumor grade (well-moderately differentiated, p = 0.008), lower tumor invasion (p 0.018) and distant relapse (p = 0.048). There was a significant interaction between HER2 status and significantly worse disease-free survival (DFS) (P = 0.039) and overall survival (OS) (P = 0.028), respectively. Conclusions: In our population, HER2 status appears to be associated with differentiated clinicopathological characteristic, worse OS and DFS and distant site of relapse in patients with resected gastric cancer." @default.
- W2891894713 created "2018-09-27" @default.
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- W2891894713 date "2017-05-20" @default.
- W2891894713 modified "2023-10-18" @default.
- W2891894713 title "Assessment of HER2 status in adenocarcinomas of the stomach or gastroesophageal junction in a Western population." @default.
- W2891894713 doi "https://doi.org/10.1200/jco.2017.35.15_suppl.e15548" @default.
- W2891894713 hasPublicationYear "2017" @default.
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