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- W2891897900 abstract "Background: Serum cytokine levels may relate to increased risk of sepsis and inflammation. The association of preoperative cytokine expression with perioperative outcomes after pancreatectomy is unknown. Methods: Preoperative serum specimens were prospectively collected on pancreatectomy patients at a single institution in 2013–2015. Enzyme-linked immunosorbent assays (ELISA) quantified serum levels of 27 cytokines. Clinical data were retrospectively analyzed from institutional databases. Primary outcomes were any complication within 30 days and Clavien Grade III–IV major complications. Perioperative risk factors for complications were analyzed by univariate (UV) and multivariate (MV) logistic regression. Results: 71 patients who underwent pancreatectomy for malignancy had available serum cytokine levels; operative procedures included Whipple (n = 43), distal (n = 21), and total pancreatectomy (n = 7). Diagnoses included pancreatic (n = 68) and duodenal adenocarcinoma (n = 2) and cholangiocarcinoma (n = 1). The incidence of any complication and major complications were 35% and 28%, respectively. On UV analysis, increasing hepatocyte growth factor (HGF) levels were associated with increased risk of complications. On MV analysis accounting for other known clinical risk factors, HGF remained independently associated with increased risk of any complication (OR 2.32; 95%CI: 1.03–5.23; p = 0.04). IL-4 expression was associated with increased risk of major complications and on MV analysis remained an independent negative prognostic factor (OR 3.48; 95%CI: 1.01–12.05; p = 0.050). Conclusion: In patients undergoing pancreatectomy for malignancy, increased preoperative serum HGF and IL-4 levels were independently associated with increased risk of any complication and major complications, respectively. These data may aid in preoperative risk stratification for patients undergoing pancreatectomy.Tabled 1VariableUnivariateMultivariateOR (95% Cl)p-valueOR (95% CI)p-valueMale Gender1.02 (0.38–2.73)0.97Age1.06 (0.97–1.03)0.07BMI0.99 (0.92–1.08)0.92Albumin0.69 (0.18–2.69)0.60ASA Class 2Ref 32.17 (0.42–11.27)0.36 45.33 (0.62–45.99)0.13Diabetes1.66 (0.47–5.82)0.43CHF1.88 (0.11–31.32)0.66Neoadjuvant Chemo1.20 (0.42–3.44)0.74Neoadjuvant XRT1.14(0.36–3.61)0.83EBL>500cc1.80 (1.07–5.17)0.044.02 (0.93–17.42)0.06Transfusion1.43 (0.29–6.98)0.66Resection Type WhippleRefRefRefRef Distal0.30 (0.09–0.96)0.040.19 (0.04–0.87)0.03 Total0.51 (0.09–2.90)0.440.20(0.02–1.77)0.15Serum IL42.65 (0.89–7.39)0.08Serum HGF2.54 (1.11–5.79)0.032.32 (1.03–5.23)0.04 Open table in a new tab" @default.
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- W2891897900 date "2018-03-01" @default.
- W2891897900 modified "2023-10-16" @default.
- W2891897900 title "Preoperative cytokine expression is associated with perioperative outcomes after pancreatectomy" @default.
- W2891897900 doi "https://doi.org/10.1016/j.hpb.2018.02.250" @default.
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