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- W2891898512 abstract "Drug delivery systems using nanoparticles can deliver to tumor cells without affecting normal cells. In this study, a novel well dispersed magnetic nano drug was synthesized. Thus, a selective drug delivery system was designed for potential cancer treatment. A new nanocomposite, poly 3,4‑dihydroxy‑l‑phenylalanine/Fe3O4 (l‑DOPA/Fe3O4), was synthesized and used for targeted Taxol® delivery to breast tumor in inbreed Balb/c mice model with or without magnetic field. Fe and Taxol® concentrations were measured by flame atomic absorption spectrometry and high-performance liquid chromatography, respectively. Antitumor effectiveness was investigated in terms of tumor growth features. In the presence of magnetic field, Taxol® was significantly deposited in tumor tissue in Taxol-nanocomposite-treated group. In addition, the Taxol®-nanocomposite-treated group with magnetic field showed higher antitumor efficacy than the commercial Taxol and Taxol-nanocomposite without magnetic field. The magnetic nanocomposite is promising for targeted Taxol® delivery to breast tumor in a mouse model yielding high performance." @default.
- W2891898512 created "2018-09-27" @default.
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- W2891898512 date "2018-12-01" @default.
- W2891898512 modified "2023-10-10" @default.
- W2891898512 title "Assessment of novel core–shell Fe3O4@poly l‑DOPA nanoparticles for targeted Taxol® delivery to breast tumor in a mouse model" @default.
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- W2891898512 doi "https://doi.org/10.1016/j.msec.2018.09.005" @default.
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