FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891898616> ?p ?o ?g. }

• W2891898616 abstract "Abstract 53BP1 with its downstream proteins, RIF1, PTIP and REV7, antagonizes BRCA1-dependent homologous recombination (HR) and promotes non-homologous end joining (NHEJ) in an unclear manner. Here we show that REV7 forms a complex with two proteins, FAM35A and C20ORF196. We demonstrate that FAM35A preferentially binds single-strand DNA (ssDNA) in vitro, and is recruited to DSBs as a complex with C20ORF196 and REV7 downstream of RIF1 in vivo. Epistasis analysis shows that both proteins act in the same pathway as RIF1 in NHEJ. The defects in HR pathway to repair DSBs and the reduction in resection of broken DNA ends in BRCA1-mutant cells can be largely suppressed by inactivating FAM35A or C20ORF196, indicating that FAM35A and C20ORF196 prevent end resection in these cells. Together, our data identified a REV7–FAM35A–C20ORF196 complex that binds and protects broken DNA ends to promote the NHEJ pathway for DSB repair." @default.
• W2891898616 created "2018-09-27" @default.
• W2891898616 creator A5002484201 @default.
• W2891898616 creator A5013487491 @default.
• W2891898616 creator A5041063655 @default.
• W2891898616 creator A5042495366 @default.
• W2891898616 creator A5047552232 @default.
• W2891898616 creator A5053780153 @default.
• W2891898616 creator A5057442657 @default.
• W2891898616 creator A5066778548 @default.
• W2891898616 creator A5077452182 @default.
• W2891898616 creator A5082799360 @default.
• W2891898616 creator A5089641579 @default.
• W2891898616 date "2018-09-25" @default.
• W2891898616 modified "2023-10-17" @default.
• W2891898616 title "An OB-fold complex controls the repair pathways for DNA double-strand breaks" @default.
• W2891898616 cites W1970771825 @default.
• W2891898616 cites W1975548607 @default.
• W2891898616 cites W1984881284 @default.
• W2891898616 cites W1987814047 @default.
• W2891898616 cites W1996443829 @default.
• W2891898616 cites W2017550130 @default.
• W2891898616 cites W2027814620 @default.
• W2891898616 cites W2037004712 @default.
• W2891898616 cites W2040681936 @default.
• W2891898616 cites W2053674184 @default.
• W2891898616 cites W2058957446 @default.
• W2891898616 cites W2064815984 @default.
• W2891898616 cites W2067427915 @default.
• W2891898616 cites W2077715915 @default.
• W2891898616 cites W2078438237 @default.
• W2891898616 cites W2090517238 @default.
• W2891898616 cites W2096391864 @default.
• W2891898616 cites W2097360161 @default.
• W2891898616 cites W2102151083 @default.
• W2891898616 cites W2120284579 @default.
• W2891898616 cites W2123215808 @default.
• W2891898616 cites W2131571249 @default.
• W2891898616 cites W2138845922 @default.
• W2891898616 cites W2146204567 @default.
• W2891898616 cites W2157899948 @default.
• W2891898616 cites W2169741450 @default.
• W2891898616 cites W2328756205 @default.
• W2891898616 cites W2580248979 @default.
• W2891898616 cites W2767918950 @default.
• W2891898616 cites W2791859276 @default.
• W2891898616 cites W2798183676 @default.
• W2891898616 cites W2803450780 @default.
• W2891898616 cites W2883657705 @default.
• W2891898616 cites W2883664363 @default.
• W2891898616 cites W2883789961 @default.
• W2891898616 cites W2884164644 @default.
• W2891898616 doi "https://doi.org/10.1038/s41467-018-06407-7" @default.
• W2891898616 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6156606" @default.
• W2891898616 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30254264" @default.
• W2891898616 hasPublicationYear "2018" @default.
• W2891898616 type Work @default.
• W2891898616 sameAs 2891898616 @default.
• W2891898616 citedByCount "70" @default.
• W2891898616 countsByYear W28918986162019 @default.
• W2891898616 countsByYear W28918986162020 @default.
• W2891898616 countsByYear W28918986162021 @default.
• W2891898616 countsByYear W28918986162022 @default.
• W2891898616 countsByYear W28918986162023 @default.
• W2891898616 crossrefType "journal-article" @default.
• W2891898616 hasAuthorship W2891898616A5002484201 @default.
• W2891898616 hasAuthorship W2891898616A5013487491 @default.
• W2891898616 hasAuthorship W2891898616A5041063655 @default.
• W2891898616 hasAuthorship W2891898616A5042495366 @default.
• W2891898616 hasAuthorship W2891898616A5047552232 @default.
• W2891898616 hasAuthorship W2891898616A5053780153 @default.
• W2891898616 hasAuthorship W2891898616A5057442657 @default.
• W2891898616 hasAuthorship W2891898616A5066778548 @default.
• W2891898616 hasAuthorship W2891898616A5077452182 @default.
• W2891898616 hasAuthorship W2891898616A5082799360 @default.
• W2891898616 hasAuthorship W2891898616A5089641579 @default.
• W2891898616 hasBestOaLocation W28918986161 @default.
• W2891898616 hasConcept C102744134 @default.
• W2891898616 hasConcept C104317684 @default.
• W2891898616 hasConcept C122917832 @default.
• W2891898616 hasConcept C134935766 @default.
• W2891898616 hasConcept C143065580 @default.
• W2891898616 hasConcept C143425029 @default.
• W2891898616 hasConcept C153911025 @default.
• W2891898616 hasConcept C185592680 @default.
• W2891898616 hasConcept C54355233 @default.
• W2891898616 hasConcept C552990157 @default.
• W2891898616 hasConcept C64894306 @default.
• W2891898616 hasConcept C86803240 @default.
• W2891898616 hasConcept C95444343 @default.
• W2891898616 hasConceptScore W2891898616C102744134 @default.
• W2891898616 hasConceptScore W2891898616C104317684 @default.
• W2891898616 hasConceptScore W2891898616C122917832 @default.
• W2891898616 hasConceptScore W2891898616C134935766 @default.
• W2891898616 hasConceptScore W2891898616C143065580 @default.
• W2891898616 hasConceptScore W2891898616C143425029 @default.
• W2891898616 hasConceptScore W2891898616C153911025 @default.
• W2891898616 hasConceptScore W2891898616C185592680 @default.
• W2891898616 hasConceptScore W2891898616C54355233 @default.
• W2891898616 hasConceptScore W2891898616C552990157 @default.

• next