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- W2891901437 endingPage "23" @default.
- W2891901437 startingPage "14" @default.
- W2891901437 abstract "RNA interference (RNAi) therapy is an emerging class of biopharmaceutical that has immense potential in cancer medicine. RNAi medicines are based on synthetic oligonucleotides that can suppress a target protein in tumour cells with high specificity. This review explores the attractive prospect of using RNAi as a radiosensitiser by targeting the DNA damage response. There are a multitude of molecular targets involved in the detection and repair of DNA damage that are suitable for this purpose. Recent developments in delivery technologies such nanoparticle carriers and conjugation strategies have allowed RNAi therapeutics to enter clinical trials in the treatment of cancer. With further progress, RNAi targeting of the DNA damage response may hold great promise in guiding radiation oncology into the era of precision medicine." @default.
- W2891901437 created "2018-09-27" @default.
- W2891901437 creator A5000023699 @default.
- W2891901437 creator A5014665196 @default.
- W2891901437 creator A5030666977 @default.
- W2891901437 creator A5042627450 @default.
- W2891901437 creator A5049455451 @default.
- W2891901437 creator A5076175632 @default.
- W2891901437 date "2018-12-01" @default.
- W2891901437 modified "2023-10-16" @default.
- W2891901437 title "RNA interference to enhance radiation therapy: Targeting the DNA damage response" @default.
- W2891901437 cites W1481099429 @default.
- W2891901437 cites W1484334610 @default.
- W2891901437 cites W1660787335 @default.
- W2891901437 cites W1857091883 @default.
- W2891901437 cites W1859060501 @default.
- W2891901437 cites W1908870105 @default.
- W2891901437 cites W1970184435 @default.
- W2891901437 cites W1971643509 @default.
- W2891901437 cites W1971822253 @default.
- W2891901437 cites W1973268287 @default.
- W2891901437 cites W1983372287 @default.
- W2891901437 cites W1983830764 @default.
- W2891901437 cites W1984424468 @default.
- W2891901437 cites W1986992145 @default.
- W2891901437 cites W1988177186 @default.
- W2891901437 cites W1992688638 @default.
- W2891901437 cites W2001054044 @default.
- W2891901437 cites W2001784394 @default.
- W2891901437 cites W2001850398 @default.
- W2891901437 cites W2004167207 @default.
- W2891901437 cites W2005390061 @default.
- W2891901437 cites W2009007206 @default.
- W2891901437 cites W2017642141 @default.
- W2891901437 cites W2019613864 @default.
- W2891901437 cites W2020469175 @default.
- W2891901437 cites W2020825769 @default.
- W2891901437 cites W2021905258 @default.
- W2891901437 cites W2025531050 @default.
- W2891901437 cites W2027017068 @default.
- W2891901437 cites W2028921845 @default.
- W2891901437 cites W2031493003 @default.
- W2891901437 cites W2035154953 @default.
- W2891901437 cites W2036911210 @default.
- W2891901437 cites W2040237389 @default.
- W2891901437 cites W2041105606 @default.
- W2891901437 cites W2048243611 @default.
- W2891901437 cites W2054899405 @default.
- W2891901437 cites W2061197983 @default.
- W2891901437 cites W2065015030 @default.
- W2891901437 cites W2073886121 @default.
- W2891901437 cites W2074218748 @default.
- W2891901437 cites W2077814905 @default.
- W2891901437 cites W2079752301 @default.
- W2891901437 cites W2082133979 @default.
- W2891901437 cites W2084403038 @default.
- W2891901437 cites W2084660043 @default.
- W2891901437 cites W2085249677 @default.
- W2891901437 cites W2087991548 @default.
- W2891901437 cites W2088801038 @default.
- W2891901437 cites W2089147663 @default.
- W2891901437 cites W2101225190 @default.
- W2891901437 cites W2102279520 @default.
- W2891901437 cites W2102752109 @default.
- W2891901437 cites W2103802203 @default.
- W2891901437 cites W2107230180 @default.
- W2891901437 cites W2110817748 @default.
- W2891901437 cites W2118980569 @default.
- W2891901437 cites W2119101863 @default.
- W2891901437 cites W2125460615 @default.
- W2891901437 cites W2126044151 @default.
- W2891901437 cites W2131978108 @default.
- W2891901437 cites W2134259738 @default.
- W2891901437 cites W2136868528 @default.
- W2891901437 cites W2138263320 @default.
- W2891901437 cites W2138733854 @default.
- W2891901437 cites W2141573080 @default.
- W2891901437 cites W2145200068 @default.
- W2891901437 cites W2148805887 @default.
- W2891901437 cites W2150092048 @default.
- W2891901437 cites W2151488213 @default.
- W2891901437 cites W2153400045 @default.
- W2891901437 cites W2154141161 @default.
- W2891901437 cites W2165267660 @default.
- W2891901437 cites W2167798860 @default.
- W2891901437 cites W2169768109 @default.
- W2891901437 cites W2173456459 @default.
- W2891901437 cites W2176599934 @default.
- W2891901437 cites W2180587227 @default.
- W2891901437 cites W2258673083 @default.
- W2891901437 cites W2281629727 @default.
- W2891901437 cites W2299264726 @default.
- W2891901437 cites W2315260912 @default.
- W2891901437 cites W2318905487 @default.
- W2891901437 cites W2405641869 @default.
- W2891901437 cites W2415357473 @default.
- W2891901437 cites W2421275313 @default.
- W2891901437 cites W2479045143 @default.