FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891905200> ?p ?o ?g. }

• W2891905200 endingPage "1663" @default.
• W2891905200 startingPage "1657" @default.
• W2891905200 abstract "Abstract Myelodysplastic syndromes (MDS) can be difficult to diagnose, especially when morphological changes in blood and marrow cells are minimal, myeloblast proportion is not increased, and the karyotype is normal. The discovery of &gt;40 genes that are recurrently somatically mutated in MDS patients raised hope that molecular genetic testing for these mutations might help clarify the diagnosis in ambiguous cases where patients present with cytopenias and nondiagnostic marrow morphological findings. However, many older healthy individuals also harbor somatic mutations in leukemia-associated driver genes, especially in DNMT3A, TET2, and ASXL1, and detection of common aging-associated mutations in a cytopenic patient can cause diagnostic uncertainty. Despite this potential confounding factor, certain somatic mutation patterns when observed in cytopenic patients confer a high likelihood of disease progression and may allow a provisional diagnosis of MDS even if morphologic dysplasia and other diagnostic criteria are absent. A subset of acquired mutations also influences risk stratification of patients with an established MDS diagnosis and can inform treatment selection. Many unanswered questions remain about the implications of specific mutations, and clinicians also vary widely in their comfort with interpreting sequencing results. Here, I review the use of molecular genetic assays in patients with possible MDS or diagnosed MDS." @default.
• W2891905200 created "2018-09-27" @default.
• W2891905200 creator A5077104483 @default.
• W2891905200 date "2018-10-18" @default.
• W2891905200 modified "2023-09-27" @default.
• W2891905200 title "How I use molecular genetic tests to evaluate patients who have or may have myelodysplastic syndromes" @default.
• W2891905200 cites W1964809738 @default.
• W2891905200 cites W1985823023 @default.
• W2891905200 cites W1992826811 @default.
• W2891905200 cites W1993236149 @default.
• W2891905200 cites W2009854509 @default.
• W2891905200 cites W2022376618 @default.
• W2891905200 cites W2026134786 @default.
• W2891905200 cites W2051978340 @default.
• W2891905200 cites W2053749374 @default.
• W2891905200 cites W2064224156 @default.
• W2891905200 cites W2069175777 @default.
• W2891905200 cites W2070152906 @default.
• W2891905200 cites W2081895311 @default.
• W2891905200 cites W2106512898 @default.
• W2891905200 cites W2107065207 @default.
• W2891905200 cites W2118462057 @default.
• W2891905200 cites W2120910826 @default.
• W2891905200 cites W2126816979 @default.
• W2891905200 cites W2131256397 @default.
• W2891905200 cites W2133832867 @default.
• W2891905200 cites W2142765738 @default.
• W2891905200 cites W2149858388 @default.
• W2891905200 cites W2171665947 @default.
• W2891905200 cites W2277853540 @default.
• W2891905200 cites W2339658711 @default.
• W2891905200 cites W2342532156 @default.
• W2891905200 cites W2406284768 @default.
• W2891905200 cites W2439825102 @default.
• W2891905200 cites W2461552262 @default.
• W2891905200 cites W2472403803 @default.
• W2891905200 cites W2486459891 @default.
• W2891905200 cites W2530899026 @default.
• W2891905200 cites W2543307778 @default.
• W2891905200 cites W2549790759 @default.
• W2891905200 cites W2557848771 @default.
• W2891905200 cites W2587066646 @default.
• W2891905200 cites W2606218280 @default.
• W2891905200 cites W2628145035 @default.
• W2891905200 cites W2724252873 @default.
• W2891905200 cites W2746871805 @default.
• W2891905200 cites W2747059835 @default.
• W2891905200 cites W2755108330 @default.
• W2891905200 cites W2759407863 @default.
• W2891905200 cites W2767788589 @default.
• W2891905200 cites W2783064655 @default.
• W2891905200 cites W2788733333 @default.
• W2891905200 cites W2796566605 @default.
• W2891905200 cites W2810697746 @default.
• W2891905200 cites W2830196912 @default.
• W2891905200 cites W4253916874 @default.
• W2891905200 cites W745434085 @default.
• W2891905200 doi "https://doi.org/10.1182/blood-2018-06-860882" @default.
• W2891905200 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30185432" @default.
• W2891905200 hasPublicationYear "2018" @default.
• W2891905200 type Work @default.
• W2891905200 sameAs 2891905200 @default.
• W2891905200 citedByCount "31" @default.
• W2891905200 countsByYear W28919052002019 @default.
• W2891905200 countsByYear W28919052002020 @default.
• W2891905200 countsByYear W28919052002021 @default.
• W2891905200 countsByYear W28919052002022 @default.
• W2891905200 countsByYear W28919052002023 @default.
• W2891905200 crossrefType "journal-article" @default.
• W2891905200 hasAuthorship W2891905200A5077104483 @default.
• W2891905200 hasBestOaLocation W28919052001 @default.
• W2891905200 hasConcept C104317684 @default.
• W2891905200 hasConcept C126322002 @default.
• W2891905200 hasConcept C143998085 @default.
• W2891905200 hasConcept C2779134260 @default.
• W2891905200 hasConcept C2780007613 @default.
• W2891905200 hasConcept C2780366003 @default.
• W2891905200 hasConcept C2780817109 @default.
• W2891905200 hasConcept C501734568 @default.
• W2891905200 hasConcept C54355233 @default.
• W2891905200 hasConcept C60644358 @default.
• W2891905200 hasConcept C71924100 @default.
• W2891905200 hasConcept C86803240 @default.
• W2891905200 hasConceptScore W2891905200C104317684 @default.
• W2891905200 hasConceptScore W2891905200C126322002 @default.
• W2891905200 hasConceptScore W2891905200C143998085 @default.
• W2891905200 hasConceptScore W2891905200C2779134260 @default.
• W2891905200 hasConceptScore W2891905200C2780007613 @default.
• W2891905200 hasConceptScore W2891905200C2780366003 @default.
• W2891905200 hasConceptScore W2891905200C2780817109 @default.
• W2891905200 hasConceptScore W2891905200C501734568 @default.
• W2891905200 hasConceptScore W2891905200C54355233 @default.
• W2891905200 hasConceptScore W2891905200C60644358 @default.
• W2891905200 hasConceptScore W2891905200C71924100 @default.
• W2891905200 hasConceptScore W2891905200C86803240 @default.
• W2891905200 hasIssue "16" @default.
• W2891905200 hasLocation W28919052001 @default.
• W2891905200 hasOpenAccess W2891905200 @default.

• next