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• W2891906291 abstract "Axotomy results in permanent loss of function after brain and spinal cord injuries due to the minimal regenerative propensity of the adult central nervous system (CNS). To identify pharmacological enhancers of axon regeneration, 960 compounds were screened for cortical neuron axonal regrowth using an in vitro cortical scrape assay. Diltiazem, verapamil, and bromopride were discovered to facilitate axon regeneration in rat cortical cultures, in the presence of chondroitin sulfate proteoglycans (CSPGs). Diltiazem, an L-type calcium channel blocker (L-CCB), also promotes axon outgrowth in adult primary mouse dorsal root ganglion (DRG) and induced human sensory (iSensory) neurons." @default.
• W2891906291 created "2018-09-27" @default.
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• W2891906291 date "2018-09-19" @default.
• W2891906291 modified "2023-10-11" @default.
• W2891906291 title "Diltiazem Promotes Regenerative Axon Growth" @default.
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• W2891906291 doi "https://doi.org/10.1007/s12035-018-1349-5" @default.
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