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• W2891915585 startingPage "832" @default.
• W2891915585 abstract "Sequencing of RNA 3′ ends has uncovered numerous sites that do not correspond to the termination sites of known transcripts. Through their 3′ untranslated regions, protein-coding RNAs interact with RNA-binding proteins and microRNAs, which regulate many properties, including RNA stability and subcellular localization. We developed the terminal exon characterization (TEC) tool ( http://tectool.unibas.ch ), which can be used with RNA-sequencing data from any species for which a genome annotation that includes sites of RNA cleavage and polyadenylation is available. We discovered hundreds of previously unknown isoforms and cell-type-specific terminal exons in human cells. Ribosome profiling data revealed that many of these isoforms were translated. By applying TECtool to single-cell sequencing data, we found that the newly identified isoforms were expressed in subpopulations of cells. Thus, TECtool enables the identification of previously unknown isoforms in well-studied cell systems and in rare cell types. TECtool identifies terminal exons from RNA-seq data, uncovering novel isoforms, many of which are translated." @default.
• W2891915585 created "2018-09-27" @default.
• W2891915585 creator A5018588101 @default.
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• W2891915585 date "2018-09-10" @default.
• W2891915585 modified "2023-10-16" @default.
• W2891915585 title "Terminal exon characterization with TECtool reveals an abundance of cell-specific isoforms" @default.
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• W2891915585 doi "https://doi.org/10.1038/s41592-018-0114-z" @default.
• W2891915585 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7611301" @default.
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