Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891916238> ?p ?o ?g. }
- W2891916238 endingPage "1730" @default.
- W2891916238 startingPage "1715" @default.
- W2891916238 abstract "The clinical success of inhibitors targeting the PD-1/PD-L1 pathway has made this an active field in cancer immunotherapy. Currently, most drugs targeting this pathway are monoclonal antibodies. Small-molecule inhibitors as the alternative to monoclonal antibodies are expected to overcome the disadvantages of mAbs which include production difficulties and their long half-life. Recently, progress has been reported on anti-PD-1/PD-L1 small-molecule inhibitors. In this paper, we review the development of inhibitors targeting the PD-1/PD-L1 pathway, focusing mainly on peptide-based and nonpeptidic small-molecule inhibitors. The structures and the preclinical and clinical studies of several peptide-based small-molecule candidate compounds in clinical trials are discussed. We also illustrate the design strategies underlying reported nonpeptidic small-molecule inhibitors and provide insight into possible future exploration. Development of small-molecule drugs for anti-PD-1/PD-L1 activity with specific cancer applications is a promising and challenging prospect." @default.
- W2891916238 created "2018-09-27" @default.
- W2891916238 creator A5011936989 @default.
- W2891916238 creator A5012420869 @default.
- W2891916238 creator A5029121472 @default.
- W2891916238 creator A5056153771 @default.
- W2891916238 creator A5060335470 @default.
- W2891916238 creator A5062542913 @default.
- W2891916238 creator A5069095478 @default.
- W2891916238 date "2018-09-24" @default.
- W2891916238 modified "2023-10-17" @default.
- W2891916238 title "Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway" @default.
- W2891916238 cites W1538902372 @default.
- W2891916238 cites W1749548564 @default.
- W2891916238 cites W1849671624 @default.
- W2891916238 cites W1915689252 @default.
- W2891916238 cites W1975867402 @default.
- W2891916238 cites W1982488143 @default.
- W2891916238 cites W1985981664 @default.
- W2891916238 cites W1992699637 @default.
- W2891916238 cites W2001287101 @default.
- W2891916238 cites W2012951244 @default.
- W2891916238 cites W2013090484 @default.
- W2891916238 cites W2016732129 @default.
- W2891916238 cites W2016983859 @default.
- W2891916238 cites W2028376975 @default.
- W2891916238 cites W2039123767 @default.
- W2891916238 cites W2044835625 @default.
- W2891916238 cites W2046972425 @default.
- W2891916238 cites W2051083170 @default.
- W2891916238 cites W2056535502 @default.
- W2891916238 cites W2060070314 @default.
- W2891916238 cites W2063264144 @default.
- W2891916238 cites W2066671159 @default.
- W2891916238 cites W2081447339 @default.
- W2891916238 cites W2083025888 @default.
- W2891916238 cites W2090031443 @default.
- W2891916238 cites W2094481139 @default.
- W2891916238 cites W2096322385 @default.
- W2891916238 cites W2098853737 @default.
- W2891916238 cites W2103532863 @default.
- W2891916238 cites W2107752337 @default.
- W2891916238 cites W2112070531 @default.
- W2891916238 cites W2114238926 @default.
- W2891916238 cites W2118471749 @default.
- W2891916238 cites W2118982164 @default.
- W2891916238 cites W2122639773 @default.
- W2891916238 cites W2124060252 @default.
- W2891916238 cites W2124427232 @default.
- W2891916238 cites W2125988127 @default.
- W2891916238 cites W2136313650 @default.
- W2891916238 cites W2139591061 @default.
- W2891916238 cites W2140975565 @default.
- W2891916238 cites W2143772132 @default.
- W2891916238 cites W2145871366 @default.
- W2891916238 cites W2148738091 @default.
- W2891916238 cites W2149748445 @default.
- W2891916238 cites W2152897456 @default.
- W2891916238 cites W2155464214 @default.
- W2891916238 cites W2160834915 @default.
- W2891916238 cites W2162889226 @default.
- W2891916238 cites W2165838507 @default.
- W2891916238 cites W2167398093 @default.
- W2891916238 cites W2177405394 @default.
- W2891916238 cites W2209812019 @default.
- W2891916238 cites W2256505400 @default.
- W2891916238 cites W2318605753 @default.
- W2891916238 cites W2329592726 @default.
- W2891916238 cites W2336130220 @default.
- W2891916238 cites W2338150527 @default.
- W2891916238 cites W2338699203 @default.
- W2891916238 cites W2414977199 @default.
- W2891916238 cites W2464483552 @default.
- W2891916238 cites W2509892577 @default.
- W2891916238 cites W2550532965 @default.
- W2891916238 cites W2590903145 @default.
- W2891916238 cites W2625296602 @default.
- W2891916238 cites W2626773261 @default.
- W2891916238 cites W2744859856 @default.
- W2891916238 cites W2749319028 @default.
- W2891916238 cites W2750317630 @default.
- W2891916238 cites W2753432434 @default.
- W2891916238 cites W2753716909 @default.
- W2891916238 cites W2757772966 @default.
- W2891916238 cites W2761508212 @default.
- W2891916238 cites W2769044114 @default.
- W2891916238 cites W2775030564 @default.
- W2891916238 cites W2789936040 @default.
- W2891916238 cites W2791483720 @default.
- W2891916238 cites W2794577178 @default.
- W2891916238 cites W2805971966 @default.
- W2891916238 cites W4230730781 @default.
- W2891916238 doi "https://doi.org/10.1021/acs.jmedchem.8b00990" @default.
- W2891916238 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30247903" @default.
- W2891916238 hasPublicationYear "2018" @default.
- W2891916238 type Work @default.
- W2891916238 sameAs 2891916238 @default.
- W2891916238 citedByCount "84" @default.