FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891916426> ?p ?o ?g. }

• W2891916426 endingPage "73" @default.
• W2891916426 startingPage "68" @default.
• W2891916426 abstract "The standard treatment for locally advanced cervical cancer is chemo-radiotherapy. The presence of the residual disease after treatment is directly related to the relapse risk and to poor survival. There is a lack of consensus on the role of a subsequent surgery due to morbidity concerns. Oncological and peri-operative outcomes of completion surgery for cervical cancer were reviewed by retrospective descriptive analysis of the eligible cases between March 2012 and March 2016. Fifteen women were identified. Ten (66.7%) had a residual tumour on their post-treatment MRI. Surgical histology indicated a residual cancer in 26.7%. There were three distant recurrences. Bowel and urinary complications were most commonly reported. Offering surgery to women with a residual cervical tumour found on MRI after chemo-radiation is beneficial, despite clear risks from the dual-modality treatment. A less radical surgery is preferable. An MRI has a reasonable negative predictive value, but this study has highlighted the need to further examine the role of MRI in predicting the residual disease and recurrence.Impact statementWhat is already known on this subject? The standard treatment for locally advanced cervical cancer is chemo-radiotherapy. The presence of residual disease after treatment is directly related to the relapse risk and poor survival. There is a lack of consensus on the role of a subsequent surgery due to morbidity concerns. The current evidence in the UK is limited, but across the world it appears that surgery can be beneficial for patients with incomplete chemo-radiotherapy, for certain histological subtypes of cervical cancer or for bulky residual disease.What do the results of this study add? The mode of surgery is more debateable, and this study concludes that both the laparoscopic and open surgeries are acceptable, but that radical surgery should be avoided as this contributes to a significant post-operative morbidity. This study explores the role of MRI imaging in predicting the residual disease and cervical cancer recurrence, concluding that a negative MRI post-chemoradiotherapy has a good negative predictive value for squamous cell cervical cancer, but otherwise can be unreliable.What are the implications of these findings for clinical practice and/or further research? An additional explored role of the MRI in predicting a recurrence in a larger cohort will be required, and it is likely that an additional assessment with PET-CT scanning will improve specificity." @default.
• W2891916426 created "2018-09-27" @default.
• W2891916426 creator A5008500355 @default.
• W2891916426 creator A5046048679 @default.
• W2891916426 creator A5046720131 @default.
• W2891916426 creator A5052255744 @default.
• W2891916426 creator A5061221375 @default.
• W2891916426 date "2018-09-19" @default.
• W2891916426 modified "2023-10-18" @default.
• W2891916426 title "Completion surgery after chemoradiotherapy for cervical cancer – is there a role? UK Cancer Centre experience of hysterectomy post chemo-radiotherapy treatment for cervical cancer" @default.
• W2891916426 cites W1966887634 @default.
• W2891916426 cites W1978384488 @default.
• W2891916426 cites W2008563644 @default.
• W2891916426 cites W2012080690 @default.
• W2891916426 cites W2053681817 @default.
• W2891916426 cites W2056754095 @default.
• W2891916426 cites W2060939688 @default.
• W2891916426 cites W2070570672 @default.
• W2891916426 cites W2103959246 @default.
• W2891916426 cites W2142553710 @default.
• W2891916426 cites W2148132011 @default.
• W2891916426 cites W2320944687 @default.
• W2891916426 cites W2585437716 @default.
• W2891916426 doi "https://doi.org/10.1080/01443615.2018.1463205" @default.
• W2891916426 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30230397" @default.
• W2891916426 hasPublicationYear "2018" @default.
• W2891916426 type Work @default.
• W2891916426 sameAs 2891916426 @default.
• W2891916426 citedByCount "13" @default.
• W2891916426 countsByYear W28919164262019 @default.
• W2891916426 countsByYear W28919164262020 @default.
• W2891916426 countsByYear W28919164262021 @default.
• W2891916426 countsByYear W28919164262022 @default.
• W2891916426 countsByYear W28919164262023 @default.
• W2891916426 crossrefType "journal-article" @default.
• W2891916426 hasAuthorship W2891916426A5008500355 @default.
• W2891916426 hasAuthorship W2891916426A5046048679 @default.
• W2891916426 hasAuthorship W2891916426A5046720131 @default.
• W2891916426 hasAuthorship W2891916426A5052255744 @default.
• W2891916426 hasAuthorship W2891916426A5061221375 @default.
• W2891916426 hasConcept C121608353 @default.
• W2891916426 hasConcept C126322002 @default.
• W2891916426 hasConcept C141071460 @default.
• W2891916426 hasConcept C2776874909 @default.
• W2891916426 hasConcept C2778220009 @default.
• W2891916426 hasConcept C2778424827 @default.
• W2891916426 hasConcept C2779134260 @default.
• W2891916426 hasConcept C2779494336 @default.
• W2891916426 hasConcept C2910227796 @default.
• W2891916426 hasConcept C509974204 @default.
• W2891916426 hasConcept C71924100 @default.
• W2891916426 hasConceptScore W2891916426C121608353 @default.
• W2891916426 hasConceptScore W2891916426C126322002 @default.
• W2891916426 hasConceptScore W2891916426C141071460 @default.
• W2891916426 hasConceptScore W2891916426C2776874909 @default.
• W2891916426 hasConceptScore W2891916426C2778220009 @default.
• W2891916426 hasConceptScore W2891916426C2778424827 @default.
• W2891916426 hasConceptScore W2891916426C2779134260 @default.
• W2891916426 hasConceptScore W2891916426C2779494336 @default.
• W2891916426 hasConceptScore W2891916426C2910227796 @default.
• W2891916426 hasConceptScore W2891916426C509974204 @default.
• W2891916426 hasConceptScore W2891916426C71924100 @default.
• W2891916426 hasIssue "1" @default.
• W2891916426 hasLocation W28919164261 @default.
• W2891916426 hasLocation W28919164262 @default.
• W2891916426 hasOpenAccess W2891916426 @default.
• W2891916426 hasPrimaryLocation W28919164261 @default.
• W2891916426 hasRelatedWork W2109983133 @default.
• W2891916426 hasRelatedWork W2134287432 @default.
• W2891916426 hasRelatedWork W2145172036 @default.
• W2891916426 hasRelatedWork W2394357887 @default.
• W2891916426 hasRelatedWork W2898811719 @default.
• W2891916426 hasRelatedWork W2944462570 @default.
• W2891916426 hasRelatedWork W2956054768 @default.
• W2891916426 hasRelatedWork W3203477016 @default.
• W2891916426 hasRelatedWork W4247169047 @default.
• W2891916426 hasRelatedWork W4253158507 @default.
• W2891916426 hasVolume "39" @default.
• W2891916426 isParatext "false" @default.
• W2891916426 isRetracted "false" @default.
• W2891916426 magId "2891916426" @default.
• W2891916426 workType "article" @default.