FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891917070> ?p ?o ?g. }

• W2891917070 abstract "The formation of intrafusal muscle (IM) fibers and their contact with afferent proprioceptive axons is critical for construction, function, and maintenance of the stretch reflex. Many factors affect the formation of IM fibers. Finding new factors and mechanisms of IM fiber formation is essential for the reconstruction of stretch reflex arc after injury.We established a coculture system of organotypic dorsal root ganglion (DRG) explants and dissociated skeletal muscle (SKM) cells. The formation of IM fibers was observed in this coculture system after neuregulin-1β (NRG-1β) incubation.We found that NRG-1β promoted outgrowth of neurites and migration of neurons from the organotypic DRG explants and that this correlated with an induction of growth-associated protein 43 (GAP-43) expression. NRG-1β also increased the amount of nuclear bag fibers and nuclear chain fibers by elevating the proportion of tyrosine kinase receptor C (TrkC) phenotypic DRG neurons. In addition, we found that the effects of NRG-1β could be blocked by inhibiting ERK1/2, PI3K/Akt, and JAK2/STAT3 signaling pathways.These data imply that NRG-1β promoted neurite outgrowth and neuronal migration from the organotypic DRG explants and that this correlated with an induction of GAP-43 expression. The modulating effects of NRG-1β on TrkC DRG neuronal phenotype may link to promote IM fiber formation. The effects produced by NRG-1β in this neuromuscular coculture system provide new data for the therapeutic potential on IM fiber formation after muscle injury." @default.
• W2891917070 created "2018-09-27" @default.
• W2891917070 creator A5019560977 @default.
• W2891917070 creator A5034054749 @default.
• W2891917070 creator A5042833434 @default.
• W2891917070 creator A5081185398 @default.
• W2891917070 creator A5086103184 @default.
• W2891917070 date "2018-09-15" @default.
• W2891917070 modified "2023-10-01" @default.
• W2891917070 title "The effects of neuregulin-1β on intrafusal muscle fiber formation in neuromuscular coculture of dorsal root ganglion explants and skeletal muscle cells" @default.
• W2891917070 cites W114710825 @default.
• W2891917070 cites W1537575198 @default.
• W2891917070 cites W1573544812 @default.
• W2891917070 cites W1662431561 @default.
• W2891917070 cites W1730315710 @default.
• W2891917070 cites W1943130530 @default.
• W2891917070 cites W1956159241 @default.
• W2891917070 cites W1968481363 @default.
• W2891917070 cites W1974773959 @default.
• W2891917070 cites W1977686946 @default.
• W2891917070 cites W1986782404 @default.
• W2891917070 cites W1986912034 @default.
• W2891917070 cites W2010027271 @default.
• W2891917070 cites W2020165890 @default.
• W2891917070 cites W2020427520 @default.
• W2891917070 cites W2021781936 @default.
• W2891917070 cites W2027338546 @default.
• W2891917070 cites W2035980530 @default.
• W2891917070 cites W2038777068 @default.
• W2891917070 cites W2038819603 @default.
• W2891917070 cites W2041019578 @default.
• W2891917070 cites W2049657217 @default.
• W2891917070 cites W2051739071 @default.
• W2891917070 cites W2052424029 @default.
• W2891917070 cites W2058588450 @default.
• W2891917070 cites W2062820112 @default.
• W2891917070 cites W2076242853 @default.
• W2891917070 cites W2080251859 @default.
• W2891917070 cites W2083135213 @default.
• W2891917070 cites W2088744636 @default.
• W2891917070 cites W2094122805 @default.
• W2891917070 cites W2096145026 @default.
• W2891917070 cites W2097865047 @default.
• W2891917070 cites W2112573898 @default.
• W2891917070 cites W2114667431 @default.
• W2891917070 cites W2127205113 @default.
• W2891917070 cites W2136790601 @default.
• W2891917070 cites W2158892210 @default.
• W2891917070 cites W2270512768 @default.
• W2891917070 cites W2279845308 @default.
• W2891917070 cites W2308053137 @default.
• W2891917070 cites W2312978285 @default.
• W2891917070 cites W2339725236 @default.
• W2891917070 cites W2423284320 @default.
• W2891917070 cites W2460652837 @default.
• W2891917070 cites W2506631790 @default.
• W2891917070 cites W2527442128 @default.
• W2891917070 cites W2528110610 @default.
• W2891917070 cites W2541542332 @default.
• W2891917070 cites W2543244164 @default.
• W2891917070 cites W2546599230 @default.
• W2891917070 cites W2561214613 @default.
• W2891917070 cites W2565008879 @default.
• W2891917070 cites W2570566583 @default.
• W2891917070 cites W2588203433 @default.
• W2891917070 cites W2594325235 @default.
• W2891917070 cites W2618038802 @default.
• W2891917070 cites W2733928987 @default.
• W2891917070 cites W2741186399 @default.
• W2891917070 cites W2742738742 @default.
• W2891917070 cites W2753714995 @default.
• W2891917070 cites W2767192054 @default.
• W2891917070 cites W2770728986 @default.
• W2891917070 cites W2774098782 @default.
• W2891917070 cites W2786959599 @default.
• W2891917070 cites W2789598930 @default.
• W2891917070 cites W2791614188 @default.
• W2891917070 cites W2792273082 @default.
• W2891917070 cites W2795177441 @default.
• W2891917070 cites W2807139341 @default.
• W2891917070 cites W619749724 @default.
• W2891917070 doi "https://doi.org/10.1186/s13395-018-0175-9" @default.
• W2891917070 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6139134" @default.
• W2891917070 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30219099" @default.
• W2891917070 hasPublicationYear "2018" @default.
• W2891917070 type Work @default.
• W2891917070 sameAs 2891917070 @default.
• W2891917070 citedByCount "10" @default.
• W2891917070 countsByYear W28919170702019 @default.
• W2891917070 countsByYear W28919170702020 @default.
• W2891917070 countsByYear W28919170702021 @default.
• W2891917070 countsByYear W28919170702022 @default.
• W2891917070 countsByYear W28919170702023 @default.
• W2891917070 crossrefType "journal-article" @default.
• W2891917070 hasAuthorship W2891917070A5019560977 @default.
• W2891917070 hasAuthorship W2891917070A5034054749 @default.
• W2891917070 hasAuthorship W2891917070A5042833434 @default.
• W2891917070 hasAuthorship W2891917070A5081185398 @default.
• W2891917070 hasAuthorship W2891917070A5086103184 @default.
• W2891917070 hasBestOaLocation W28919170701 @default.

• next