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• W2891917747 abstract "There are several practical applications of these findings. First, our findings indicate that no clinical feature or combination of features is pathognomonic for malignant transformation, defined as class 2 gene expression profile, in small suspicious choroidal melanocytic tumors. Thus, caution is urged in making treatment decisions based on these features in the absence of documented growth. Nevertheless, these features (especially tumor thickness, subretinal fluid, and orange pigment) are valuable for gauging the frequency of visits to monitor for growth. Second, the only commonly used choroidal nevus risk factor that was associated with malignant transformation was tumor thickness, emphasizing the importance of careful thickness measurements by an experienced echographer. Since there is some inter- and intra-observer variability in ultrasound thickness measurements, it may be prudent to recheck tumors with borderline significant thickness (2.0–2.5 mm) prior to making a treatment decision. Third, although the risk of a small tumor having the class 2 profile increased with age, it is important to monitor younger patients periodically for tumor growth. Finally, our results suggest that the vast majority of small suspicious choroidal melanocytic tumors can be observed safely without treatment, as long as growth is not documented. Future improvements in noninvasive imaging may improve the ability to detect small choroidal melanocytic tumors that have undergone malignant transformation without prognostic biopsy." @default.
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• W2891917747 date "2019-01-01" @default.
• W2891917747 modified "2023-10-14" @default.
• W2891917747 title "Are Risk Factors for Growth of Choroidal Nevi Associated With Malignant Transformation? Assessment With a Validated Genomic Biomarker" @default.
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• W2891917747 doi "https://doi.org/10.1016/j.ajo.2018.08.045" @default.
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