Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891922360> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W2891922360 abstract "Immunosuppressivetherapyintransplantationremainsratherunspecificwithknownsideeffects ofagenerally suppressed immune system. Studies provided clear evidence for an increased susceptibilityforinfectionsandalsocancerintheimmunosuppressedpatientpopulation.One possibleway toaddressthisproblemis thediscoveryofagentswithbothimmunosuppressive and anti-cancer properties. Here, we tested the effect ofrapamycin versus cyclosporine on tumorgrowthandgraftsurvivalintransplantedmicesimultaneouslybearingtumors. Inone model, C57Bl!6 mice receivedsubcutaneousimplantsofsyngenic B16 melanomacells; 7days lateravascularizedheterotopicC3Hhearttransplantwasperformed.Inasecondmodel, BALBI cmice receivedsubcutaneoussyngenic CT-26 colonadenocarcinomacells 7days beforeC3H ear-hearttransplantation.Rapamycinorcyclosporinetreatmentwas initiatedalso onday7 aftertumor-implantation.Inthe C57Bl/6 model, B16tumorsgrewfor 2- 3weeksbeforemice diedfromtumorcomplications. However,rapamycintreatmentprotectedallografts,permitted animalsurvival,andinhibitedtumorgrowth.Incontrast,cyclosporine-treatedmicediedfrom advancingtumors,albeit,withafunctioningallograft.SimilarfindingswereobservedwithCT 26tumorsandear-heart-transplantsinBalb/cmice. Einleitung DieimmunsuppressiveTherapietransplantierterPatientenistweiterhinrelativunspezifischund" @default.
- W2891922360 created "2018-09-27" @default.
- W2891922360 creator A5007844856 @default.
- W2891922360 creator A5013971506 @default.
- W2891922360 creator A5020876647 @default.
- W2891922360 creator A5059097215 @default.
- W2891922360 creator A5075523697 @default.
- W2891922360 date "2004-01-01" @default.
- W2891922360 modified "2023-09-27" @default.
- W2891922360 title "Rapamycin verhindert Abstossung und Tumorwachstum in einem Tumor-Transplantations-Modell in der Maus Rapamycin inhibits graft rejection and tumor growth in a tumor transplant model in mice" @default.
- W2891922360 cites W1521598031 @default.
- W2891922360 cites W2021299297 @default.
- W2891922360 cites W2026351725 @default.
- W2891922360 cites W2027286769 @default.
- W2891922360 hasPublicationYear "2004" @default.
- W2891922360 type Work @default.
- W2891922360 sameAs 2891922360 @default.
- W2891922360 citedByCount "0" @default.
- W2891922360 crossrefType "journal-article" @default.
- W2891922360 hasAuthorship W2891922360A5007844856 @default.
- W2891922360 hasAuthorship W2891922360A5013971506 @default.
- W2891922360 hasAuthorship W2891922360A5020876647 @default.
- W2891922360 hasAuthorship W2891922360A5059097215 @default.
- W2891922360 hasAuthorship W2891922360A5075523697 @default.
- W2891922360 hasConcept C126322002 @default.
- W2891922360 hasConcept C203014093 @default.
- W2891922360 hasConcept C2778849806 @default.
- W2891922360 hasConcept C2911091166 @default.
- W2891922360 hasConcept C502942594 @default.
- W2891922360 hasConcept C71924100 @default.
- W2891922360 hasConcept C8891405 @default.
- W2891922360 hasConceptScore W2891922360C126322002 @default.
- W2891922360 hasConceptScore W2891922360C203014093 @default.
- W2891922360 hasConceptScore W2891922360C2778849806 @default.
- W2891922360 hasConceptScore W2891922360C2911091166 @default.
- W2891922360 hasConceptScore W2891922360C502942594 @default.
- W2891922360 hasConceptScore W2891922360C71924100 @default.
- W2891922360 hasConceptScore W2891922360C8891405 @default.
- W2891922360 hasLocation W28919223601 @default.
- W2891922360 hasOpenAccess W2891922360 @default.
- W2891922360 hasPrimaryLocation W28919223601 @default.
- W2891922360 hasRelatedWork W1956437111 @default.
- W2891922360 hasRelatedWork W1968094135 @default.
- W2891922360 hasRelatedWork W1969399156 @default.
- W2891922360 hasRelatedWork W1978625409 @default.
- W2891922360 hasRelatedWork W1984897533 @default.
- W2891922360 hasRelatedWork W1985710633 @default.
- W2891922360 hasRelatedWork W1987186405 @default.
- W2891922360 hasRelatedWork W2008246445 @default.
- W2891922360 hasRelatedWork W2060439125 @default.
- W2891922360 hasRelatedWork W2064503410 @default.
- W2891922360 hasRelatedWork W2069781304 @default.
- W2891922360 hasRelatedWork W2071133503 @default.
- W2891922360 hasRelatedWork W2102896793 @default.
- W2891922360 hasRelatedWork W2146765866 @default.
- W2891922360 hasRelatedWork W2324347192 @default.
- W2891922360 hasRelatedWork W2400648698 @default.
- W2891922360 hasRelatedWork W2581312023 @default.
- W2891922360 hasRelatedWork W2615118385 @default.
- W2891922360 hasRelatedWork W2900779164 @default.
- W2891922360 hasRelatedWork W3014889639 @default.
- W2891922360 isParatext "false" @default.
- W2891922360 isRetracted "false" @default.
- W2891922360 magId "2891922360" @default.
- W2891922360 workType "article" @default.