Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891923616> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2891923616 endingPage "276" @default.
- W2891923616 startingPage "262" @default.
- W2891923616 abstract "The purpose is to demonstrate heterotopic neurones and their synaptic plexi within the U-fibre layer beneath focal cortical dysplasias (FCD).This prospective qualitative neuropathological study included 23 patients, ages from 3 months to 17 years: resections at epileptogenic foci in 10 FCD Ia; 6 FCD IIa,b; 2 FCD IIIa,d; 3 HME; 2 TSC; 8 controls.immunoreactivities for synaptophysin, NeuN, MAP2, SMI32, calretinin, GFAP, vimentin, α-B-crystallin. Bielschowsky silver; LFB; mitochondrial enzyme histochemistry (frozen sections).Subcortical white matter in FCD exhibited neuronal dispersion within U-fibres in FCD I, II and also deep white matter neuronal clusters in FCD II, HME, TSC. Neurones reacted for NeuN, MAP2; few for calretinin. Synaptophysin well demonstrated elaborate U-fibre plexi including axones between U-fibre neurones and projecting to overlying cortex. Deep white matter axones interconnected heterotopia but did not penetrate U-fibres to reach cortex. Mitochondrial enzymatic activity was intense in some neurones, normal in others. Glial α-B-crystallin served as a marker of epileptogenic zones identified electrographically.U-fibre synaptic plexi contribute to excitatory circuitry in the cortex and thus to epileptic networks. Deep white matter neurones form local, less integrated plexi except transmantle dysplasias continuous with cortex. U-fibres may be a barrier to axonal penetration from deep heterotopia. Hypermetabolic neurones suggest repetitive ictogenic depolarizations. Gyral resections should include the U-fibre layer. Neuropathology reports should describe subcortical plexi. Synaptophysin immunoreactivity is a valuable supplement for this purpose. ." @default.
- W2891923616 created "2018-09-27" @default.
- W2891923616 creator A5048722249 @default.
- W2891923616 creator A5060265979 @default.
- W2891923616 creator A5060418334 @default.
- W2891923616 creator A5070146371 @default.
- W2891923616 date "2018-11-01" @default.
- W2891923616 modified "2023-09-25" @default.
- W2891923616 title "Synaptic plexi of U-fibre layer beneath focal cortical dysplasias: Role in epileptic networks" @default.
- W2891923616 doi "https://doi.org/10.5414/np301103" @default.
- W2891923616 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30232955" @default.
- W2891923616 hasPublicationYear "2018" @default.
- W2891923616 type Work @default.
- W2891923616 sameAs 2891923616 @default.
- W2891923616 citedByCount "22" @default.
- W2891923616 countsByYear W28919236162019 @default.
- W2891923616 countsByYear W28919236162020 @default.
- W2891923616 countsByYear W28919236162021 @default.
- W2891923616 countsByYear W28919236162022 @default.
- W2891923616 countsByYear W28919236162023 @default.
- W2891923616 crossrefType "journal-article" @default.
- W2891923616 hasAuthorship W2891923616A5048722249 @default.
- W2891923616 hasAuthorship W2891923616A5060265979 @default.
- W2891923616 hasAuthorship W2891923616A5060418334 @default.
- W2891923616 hasAuthorship W2891923616A5070146371 @default.
- W2891923616 hasConcept C105702510 @default.
- W2891923616 hasConcept C126838900 @default.
- W2891923616 hasConcept C142724271 @default.
- W2891923616 hasConcept C143409427 @default.
- W2891923616 hasConcept C169760540 @default.
- W2891923616 hasConcept C204232928 @default.
- W2891923616 hasConcept C2777209535 @default.
- W2891923616 hasConcept C2777348757 @default.
- W2891923616 hasConcept C2779134260 @default.
- W2891923616 hasConcept C2780130745 @default.
- W2891923616 hasConcept C2781100881 @default.
- W2891923616 hasConcept C2781192897 @default.
- W2891923616 hasConcept C2781404787 @default.
- W2891923616 hasConcept C2781444307 @default.
- W2891923616 hasConcept C71924100 @default.
- W2891923616 hasConcept C86803240 @default.
- W2891923616 hasConceptScore W2891923616C105702510 @default.
- W2891923616 hasConceptScore W2891923616C126838900 @default.
- W2891923616 hasConceptScore W2891923616C142724271 @default.
- W2891923616 hasConceptScore W2891923616C143409427 @default.
- W2891923616 hasConceptScore W2891923616C169760540 @default.
- W2891923616 hasConceptScore W2891923616C204232928 @default.
- W2891923616 hasConceptScore W2891923616C2777209535 @default.
- W2891923616 hasConceptScore W2891923616C2777348757 @default.
- W2891923616 hasConceptScore W2891923616C2779134260 @default.
- W2891923616 hasConceptScore W2891923616C2780130745 @default.
- W2891923616 hasConceptScore W2891923616C2781100881 @default.
- W2891923616 hasConceptScore W2891923616C2781192897 @default.
- W2891923616 hasConceptScore W2891923616C2781404787 @default.
- W2891923616 hasConceptScore W2891923616C2781444307 @default.
- W2891923616 hasConceptScore W2891923616C71924100 @default.
- W2891923616 hasConceptScore W2891923616C86803240 @default.
- W2891923616 hasIssue "6" @default.
- W2891923616 hasLocation W28919236161 @default.
- W2891923616 hasLocation W28919236162 @default.
- W2891923616 hasOpenAccess W2891923616 @default.
- W2891923616 hasPrimaryLocation W28919236161 @default.
- W2891923616 hasRelatedWork W1520398982 @default.
- W2891923616 hasRelatedWork W1999664097 @default.
- W2891923616 hasRelatedWork W2048295415 @default.
- W2891923616 hasRelatedWork W2049832667 @default.
- W2891923616 hasRelatedWork W2116401508 @default.
- W2891923616 hasRelatedWork W2380612979 @default.
- W2891923616 hasRelatedWork W2387964749 @default.
- W2891923616 hasRelatedWork W2502944989 @default.
- W2891923616 hasRelatedWork W2891923616 @default.
- W2891923616 hasRelatedWork W2914835374 @default.
- W2891923616 hasVolume "37" @default.
- W2891923616 isParatext "false" @default.
- W2891923616 isRetracted "false" @default.
- W2891923616 magId "2891923616" @default.
- W2891923616 workType "article" @default.