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- W2891925174 abstract "We investigated whether DNA methylation regulates expression of LPL and PI3K complex genes in chronic lymphocytic leukemia (CLL) and evaluated the prognostic significance of LPL promoter methylation in CLL patients. Patients & methods: Methylation of LPL promoter was assessed in 112 patients using methylation-sensitive high-resolution melting (MS-HRM).Patients with a fully or heterogeneously methylated LPL promoter had significantly longer median time to treatment (p < 0.001) and 75% lower (hazard ratio: 0.25; 95% CI: 0.15-0.42; p < 0.001) risk of requirement for treatment as opposed to patients with nonmethylated promoter. Multivariate modeling confirmed independent prognostic value of these findings.Chronic lymphocytic leukemia patients with a fully or heterogeneously methylated LPL gene promoter display indolent disease course and acquisition of heterogeneous methylation of LPL promoter is insufficient to induce gene expression." @default.
- W2891925174 created "2018-09-27" @default.
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- W2891925174 date "2018-09-01" @default.
- W2891925174 modified "2023-10-18" @default.
- W2891925174 title "Chronic lymphocytic leukemia patients with heterogeneously or fully methylatedLPLpromotor display longer time to treatment" @default.
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- W2891925174 doi "https://doi.org/10.2217/epi-2018-0020" @default.
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