FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891926051> ?p ?o ?g. }

• W2891926051 abstract "Hypoxia-inducible factor 1α (HIF-1α) is essential in hepatocellular carcinoma (HCC) glycolysis and progression. Yes-associated protein (YAP) is a powerful regulator and is overexpressed in many cancers, including HCC. The regulatory mechanism of YAP and HIF-1α in HCC glycolysis is unknown. We detected YAP expression in 54 matched HCC tissues and the adjacent noncancerous tissues. The relationship between YAP mRNA expression and that of HIF-1α was analyzed using The Cancer Genome Atlas HCC tissue data. We cultured HepG2 and Huh7 HCC cells under normoxic (20% O2) and hypoxic (1% O2) conditions, and measured the lactate and glucose levels, migration and invasive capability, and the molecular mechanism of HCC cell glycolysis and progression. In this study, we detected YAP expression in 54 matched HCC tissues and the adjacent noncancerous tissues. We observed that hypoxia-induced YAP activation is crucial for accelerating HCC cell glycolysis. Hypoxia inhibited the Hippo signaling pathway and promoted YAP nuclear localization, and decreased phosphorylated YAP expression in HCC cells. YAP knockdown inhibited HCC cell glycolysis under hypoxic. Mechanistically, hypoxic stress in the HCC cells promoted YAP binding to HIF-1α in the nucleus and sustained HIF-1α protein stability to bind to PKM2 gene and directly activates PKM2 transcription to accelerate glycolysis. Our findings describe a new regulatory mechanism of hypoxia-mediated HCC metabolism, and YAP might be a promising therapeutic target in HCC." @default.
• W2891926051 created "2018-09-27" @default.
• W2891926051 creator A5015475347 @default.
• W2891926051 creator A5026507924 @default.
• W2891926051 creator A5027444774 @default.
• W2891926051 creator A5035804461 @default.
• W2891926051 creator A5056584794 @default.
• W2891926051 creator A5061313869 @default.
• W2891926051 creator A5067536358 @default.
• W2891926051 creator A5072818182 @default.
• W2891926051 creator A5078039491 @default.
• W2891926051 creator A5085142676 @default.
• W2891926051 date "2018-09-04" @default.
• W2891926051 modified "2023-10-17" @default.
• W2891926051 title "Yes-associated protein (YAP) binds to HIF-1α and sustains HIF-1α protein stability to promote hepatocellular carcinoma cell glycolysis under hypoxic stress" @default.
• W2891926051 cites W1946514197 @default.
• W2891926051 cites W1947488048 @default.
• W2891926051 cites W1949381744 @default.
• W2891926051 cites W1955705095 @default.
• W2891926051 cites W1963272969 @default.
• W2891926051 cites W1979658237 @default.
• W2891926051 cites W1991552327 @default.
• W2891926051 cites W1992294689 @default.
• W2891926051 cites W1994302891 @default.
• W2891926051 cites W2004480757 @default.
• W2891926051 cites W2011639478 @default.
• W2891926051 cites W2020511240 @default.
• W2891926051 cites W2027150010 @default.
• W2891926051 cites W2031354391 @default.
• W2891926051 cites W2079015343 @default.
• W2891926051 cites W2082483448 @default.
• W2891926051 cites W2085551560 @default.
• W2891926051 cites W2091267676 @default.
• W2891926051 cites W2096361995 @default.
• W2891926051 cites W2098692163 @default.
• W2891926051 cites W2103423847 @default.
• W2891926051 cites W2130410032 @default.
• W2891926051 cites W2132256680 @default.
• W2891926051 cites W2141595533 @default.
• W2891926051 cites W2146044826 @default.
• W2891926051 cites W2148056172 @default.
• W2891926051 cites W2159196011 @default.
• W2891926051 cites W2167978765 @default.
• W2891926051 cites W2168636113 @default.
• W2891926051 cites W2231303906 @default.
• W2891926051 cites W2272984102 @default.
• W2891926051 cites W2299368506 @default.
• W2891926051 cites W2344746583 @default.
• W2891926051 cites W2409923755 @default.
• W2891926051 cites W2415278285 @default.
• W2891926051 cites W2503699204 @default.
• W2891926051 cites W2569647861 @default.
• W2891926051 cites W2582845364 @default.
• W2891926051 cites W2587552204 @default.
• W2891926051 cites W2589026565 @default.
• W2891926051 cites W2593956604 @default.
• W2891926051 cites W2594809404 @default.
• W2891926051 cites W2601757086 @default.
• W2891926051 cites W2604979724 @default.
• W2891926051 cites W2607127660 @default.
• W2891926051 cites W2607129810 @default.
• W2891926051 cites W2621296296 @default.
• W2891926051 cites W2736112762 @default.
• W2891926051 cites W2747662856 @default.
• W2891926051 cites W2753173755 @default.
• W2891926051 cites W2784901213 @default.
• W2891926051 doi "https://doi.org/10.1186/s13046-018-0892-2" @default.
• W2891926051 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6123950" @default.
• W2891926051 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30180863" @default.
• W2891926051 hasPublicationYear "2018" @default.
• W2891926051 type Work @default.
• W2891926051 sameAs 2891926051 @default.
• W2891926051 citedByCount "125" @default.
• W2891926051 countsByYear W28919260512018 @default.
• W2891926051 countsByYear W28919260512019 @default.
• W2891926051 countsByYear W28919260512020 @default.
• W2891926051 countsByYear W28919260512021 @default.
• W2891926051 countsByYear W28919260512022 @default.
• W2891926051 countsByYear W28919260512023 @default.
• W2891926051 crossrefType "journal-article" @default.
• W2891926051 hasAuthorship W2891926051A5015475347 @default.
• W2891926051 hasAuthorship W2891926051A5026507924 @default.
• W2891926051 hasAuthorship W2891926051A5027444774 @default.
• W2891926051 hasAuthorship W2891926051A5035804461 @default.
• W2891926051 hasAuthorship W2891926051A5056584794 @default.
• W2891926051 hasAuthorship W2891926051A5061313869 @default.
• W2891926051 hasAuthorship W2891926051A5067536358 @default.
• W2891926051 hasAuthorship W2891926051A5072818182 @default.
• W2891926051 hasAuthorship W2891926051A5078039491 @default.
• W2891926051 hasAuthorship W2891926051A5085142676 @default.
• W2891926051 hasBestOaLocation W28919260511 @default.
• W2891926051 hasConcept C104317684 @default.
• W2891926051 hasConcept C10730799 @default.
• W2891926051 hasConcept C1491633281 @default.
• W2891926051 hasConcept C160450060 @default.
• W2891926051 hasConcept C172512520 @default.
• W2891926051 hasConcept C173396325 @default.
• W2891926051 hasConcept C178790620 @default.
• W2891926051 hasConcept C185592680 @default.
• W2891926051 hasConcept C190283241 @default.

• next