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• W2891926277 abstract "Abstract Objective Hypothalamic Pro-opiomelanocortin (POMC) and Neuropeptide Y/Agouti-Related Peptide (NPY/AgRP) neurons are critical nodes of a circuit within the brain that sense key metabolic cues as well as regulate metabolism. Importantly, these neurons retain an innate ability to rapidly reorganize synaptic inputs and electrophysiological properties in response to metabolic state. While the cellular properties of these neurons have been investigated in the context of obesity, much less is known about the effects of exercise training. Methods In order to further investigate this issue, we utilized neuron-specific transgenic mouse models to identify POMC and NPY/AgRP neurons for patch-clamp electrophysiology experiments. Results Using whole-cell patch-clamp electrophysiology, we found exercise depolarized and increased firing rate of arcuate POMC neurons. The increased excitability of POMC neurons was concomitant with increased excitatory inputs to these neurons. In agreement with recent work suggesting leptin plays an important role in the synaptic (re)organization of POMC neurons, POMC neurons which express leptin receptors were more sensitive to exercise-induced changes in biophysical properties. Opposite to effects observed in POMC neurons, NPY neurons were shunted toward inhibition following exercise. Conclusions Together, these data support a rapid reorganization of synaptic inputs and biophysical properties in response to exercise, which may facilitate adaptations to altered energy balance and glucose metabolism." @default.
• W2891926277 created "2018-09-27" @default.
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• W2891926277 date "2018-12-01" @default.
• W2891926277 modified "2023-10-16" @default.
• W2891926277 title "Cellular and synaptic reorganization of arcuate NPY/AgRP and POMC neurons after exercise" @default.
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• W2891926277 doi "https://doi.org/10.1016/j.molmet.2018.08.011" @default.
• W2891926277 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6308029" @default.
• W2891926277 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30292523" @default.
• W2891926277 hasPublicationYear "2018" @default.
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