FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891927706> ?p ?o ?g. }

• W2891927706 endingPage "11" @default.
• W2891927706 startingPage "8" @default.
• W2891927706 abstract "Ca2+ dysregulation is a hallmark of Alzheimer disease (AD) and affects numerous and diverse signaling cascades linked to neurodegeneration and cognitive decline. Increasing evidence suggests that the protein phosphatase calcineurin (CN) mediates or exacerbates AD pathophysiology through activation of the NFAT family of transcription factors. In this editorial, we discuss work by Hopp et al, , which uncovered a novel role of CN/NFAT signaling in controlling global gene expression in hippocampal neurons of intact mice. Interestingly, the authors showed that elevated CN expression/activity in neurons plays a major role in transcriptional suppression. Many of the genes differentially affected by CN were related to synapse function and NFAT binding, and exhibited similar patterns of downregulation in previous studies on human AD biospecimens. Results are discussed in context with emerging roles for CN/NFATs in astrocyte signaling as they pertain to Ca2+ dysregulation and the progression of neurodegeneration and cognitive loss with AD." @default.
• W2891927706 created "2018-09-27" @default.
• W2891927706 creator A5003116077 @default.
• W2891927706 date "2018-09-07" @default.
• W2891927706 modified "2023-10-14" @default.
• W2891927706 title "Calcineurin: directing the damage in Alzheimer disease" @default.
• W2891927706 cites W1545797843 @default.
• W2891927706 cites W1550942186 @default.
• W2891927706 cites W1953584638 @default.
• W2891927706 cites W1983399609 @default.
• W2891927706 cites W1984899161 @default.
• W2891927706 cites W1988278010 @default.
• W2891927706 cites W2000495890 @default.
• W2891927706 cites W2006140418 @default.
• W2891927706 cites W2027616725 @default.
• W2891927706 cites W2044904524 @default.
• W2891927706 cites W2061466239 @default.
• W2891927706 cites W2106729121 @default.
• W2891927706 cites W2109453374 @default.
• W2891927706 cites W2116015828 @default.
• W2891927706 cites W2134841460 @default.
• W2891927706 cites W2153438315 @default.
• W2891927706 cites W2405226109 @default.
• W2891927706 cites W2603451911 @default.
• W2891927706 cites W2618537066 @default.
• W2891927706 cites W2805886206 @default.
• W2891927706 doi "https://doi.org/10.1111/jnc.14475" @default.
• W2891927706 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6181764" @default.
• W2891927706 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30256415" @default.
• W2891927706 hasPublicationYear "2018" @default.
• W2891927706 type Work @default.
• W2891927706 sameAs 2891927706 @default.
• W2891927706 citedByCount "6" @default.
• W2891927706 countsByYear W28919277062019 @default.
• W2891927706 countsByYear W28919277062022 @default.
• W2891927706 countsByYear W28919277062023 @default.
• W2891927706 crossrefType "journal-article" @default.
• W2891927706 hasAuthorship W2891927706A5003116077 @default.
• W2891927706 hasBestOaLocation W28919277061 @default.
• W2891927706 hasConcept C104317684 @default.
• W2891927706 hasConcept C126322002 @default.
• W2891927706 hasConcept C127561419 @default.
• W2891927706 hasConcept C128057223 @default.
• W2891927706 hasConcept C151730666 @default.
• W2891927706 hasConcept C169760540 @default.
• W2891927706 hasConcept C189938988 @default.
• W2891927706 hasConcept C2776925932 @default.
• W2891927706 hasConcept C2777542381 @default.
• W2891927706 hasConcept C2779134260 @default.
• W2891927706 hasConcept C2779343474 @default.
• W2891927706 hasConcept C2911091166 @default.
• W2891927706 hasConcept C502032728 @default.
• W2891927706 hasConcept C529278444 @default.
• W2891927706 hasConcept C54355233 @default.
• W2891927706 hasConcept C71924100 @default.
• W2891927706 hasConcept C86339819 @default.
• W2891927706 hasConcept C86803240 @default.
• W2891927706 hasConcept C95444343 @default.
• W2891927706 hasConceptScore W2891927706C104317684 @default.
• W2891927706 hasConceptScore W2891927706C126322002 @default.
• W2891927706 hasConceptScore W2891927706C127561419 @default.
• W2891927706 hasConceptScore W2891927706C128057223 @default.
• W2891927706 hasConceptScore W2891927706C151730666 @default.
• W2891927706 hasConceptScore W2891927706C169760540 @default.
• W2891927706 hasConceptScore W2891927706C189938988 @default.
• W2891927706 hasConceptScore W2891927706C2776925932 @default.
• W2891927706 hasConceptScore W2891927706C2777542381 @default.
• W2891927706 hasConceptScore W2891927706C2779134260 @default.
• W2891927706 hasConceptScore W2891927706C2779343474 @default.
• W2891927706 hasConceptScore W2891927706C2911091166 @default.
• W2891927706 hasConceptScore W2891927706C502032728 @default.
• W2891927706 hasConceptScore W2891927706C529278444 @default.
• W2891927706 hasConceptScore W2891927706C54355233 @default.
• W2891927706 hasConceptScore W2891927706C71924100 @default.
• W2891927706 hasConceptScore W2891927706C86339819 @default.
• W2891927706 hasConceptScore W2891927706C86803240 @default.
• W2891927706 hasConceptScore W2891927706C95444343 @default.
• W2891927706 hasFunder F4320332161 @default.
• W2891927706 hasIssue "1" @default.
• W2891927706 hasLocation W28919277061 @default.
• W2891927706 hasLocation W28919277062 @default.
• W2891927706 hasLocation W28919277063 @default.
• W2891927706 hasLocation W28919277064 @default.
• W2891927706 hasOpenAccess W2891927706 @default.
• W2891927706 hasPrimaryLocation W28919277061 @default.
• W2891927706 hasRelatedWork W1939884651 @default.
• W2891927706 hasRelatedWork W1976983358 @default.
• W2891927706 hasRelatedWork W1980572152 @default.
• W2891927706 hasRelatedWork W2030468659 @default.
• W2891927706 hasRelatedWork W2068547732 @default.
• W2891927706 hasRelatedWork W2102080208 @default.
• W2891927706 hasRelatedWork W21927977 @default.
• W2891927706 hasRelatedWork W2890680891 @default.
• W2891927706 hasRelatedWork W2913211778 @default.
• W2891927706 hasRelatedWork W3211519297 @default.
• W2891927706 hasVolume "147" @default.
• W2891927706 isParatext "false" @default.
• W2891927706 isRetracted "false" @default.

• next