FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891929410> ?p ?o ?g. }

• W2891929410 endingPage "805" @default.
• W2891929410 startingPage "797" @default.
• W2891929410 abstract "Research into injectable volatile anesthetics has been ongoing for approximately 40 years, with limited success, in an attempt to address the deficiencies of inhalational anesthesia. The purpose of this work was to formulate and optimize volatile anesthetic carrier emulsions based on our prior work in perfluorocarbon emulsions.Perfluorocarbons were screened for their volatilty and emulsion stability. Optimal anesthetic emulsions were manufactured by high pressure homogenization of a select, clinically relevant perfluorocarbon, isoflurane and a surfactant-containing aqueous phase. Longitudinal particle size, polydispersity and isoflurane content analysis was performed. Observational studies of in vivo efficacy and safety were performed in 225-300 g Lewis Rats (n = 34) with blood chemistry and post study tissue pathology analysis.Emulsion particle size and isolflurane content in select emulsions were stable at room temperature greater than 300 days. This stability was depedent on perfluorocarbon molecular weight and boiling point. in vivo, emulsions demonstrated a rapid onset and offset. Variability in onset metrics (loss of righting reflex, pain reflexes and time to recovery) was less than 40% amongst individual emulsion preparations (n = 9) utilized in induction trials. No adverse effects due to the intravenous administration of emulsions were observed in blood chemistry results or post-study pathological examination.These formulations showed stability, safety and efficacy. In addition to induction and general anesthesia, these emulsions could have utility in global health or in military applications where equipment and resources are limited." @default.
• W2891929410 created "2018-09-27" @default.
• W2891929410 creator A5001606611 @default.
• W2891929410 creator A5026981546 @default.
• W2891929410 creator A5037258164 @default.
• W2891929410 creator A5057583356 @default.
• W2891929410 creator A5074962892 @default.
• W2891929410 creator A5087763962 @default.
• W2891929410 creator A5091187317 @default.
• W2891929410 date "2018-12-01" @default.
• W2891929410 modified "2023-10-16" @default.
• W2891929410 title "Stable perfluorocarbon emulsions for the delivery of halogenated ether anesthetics" @default.
• W2891929410 cites W1578997959 @default.
• W2891929410 cites W1585105383 @default.
• W2891929410 cites W1964041073 @default.
• W2891929410 cites W1964403076 @default.
• W2891929410 cites W1969472123 @default.
• W2891929410 cites W1973603095 @default.
• W2891929410 cites W1981773015 @default.
• W2891929410 cites W1995526666 @default.
• W2891929410 cites W1997051385 @default.
• W2891929410 cites W2001584867 @default.
• W2891929410 cites W2004838689 @default.
• W2891929410 cites W2007941205 @default.
• W2891929410 cites W2030389831 @default.
• W2891929410 cites W2035715355 @default.
• W2891929410 cites W2040960121 @default.
• W2891929410 cites W2042727007 @default.
• W2891929410 cites W2046278973 @default.
• W2891929410 cites W2048618717 @default.
• W2891929410 cites W2055720761 @default.
• W2891929410 cites W2060229844 @default.
• W2891929410 cites W2065258462 @default.
• W2891929410 cites W2069427193 @default.
• W2891929410 cites W2074044765 @default.
• W2891929410 cites W2076675707 @default.
• W2891929410 cites W2079103894 @default.
• W2891929410 cites W2083136075 @default.
• W2891929410 cites W2093634709 @default.
• W2891929410 cites W2097131673 @default.
• W2891929410 cites W2100398426 @default.
• W2891929410 cites W2105816306 @default.
• W2891929410 cites W2112217944 @default.
• W2891929410 cites W2112852178 @default.
• W2891929410 cites W2114430123 @default.
• W2891929410 cites W2123753816 @default.
• W2891929410 cites W2137700456 @default.
• W2891929410 cites W2144314727 @default.
• W2891929410 cites W2294303178 @default.
• W2891929410 cites W2312497471 @default.
• W2891929410 cites W4236695518 @default.
• W2891929410 doi "https://doi.org/10.1016/j.colsurfb.2018.09.024" @default.
• W2891929410 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30342412" @default.
• W2891929410 hasPublicationYear "2018" @default.
• W2891929410 type Work @default.
• W2891929410 sameAs 2891929410 @default.
• W2891929410 citedByCount "4" @default.
• W2891929410 countsByYear W28919294102020 @default.
• W2891929410 countsByYear W28919294102021 @default.
• W2891929410 crossrefType "journal-article" @default.
• W2891929410 hasAuthorship W2891929410A5001606611 @default.
• W2891929410 hasAuthorship W2891929410A5026981546 @default.
• W2891929410 hasAuthorship W2891929410A5037258164 @default.
• W2891929410 hasAuthorship W2891929410A5057583356 @default.
• W2891929410 hasAuthorship W2891929410A5074962892 @default.
• W2891929410 hasAuthorship W2891929410A5087763962 @default.
• W2891929410 hasAuthorship W2891929410A5091187317 @default.
• W2891929410 hasConcept C11432220 @default.
• W2891929410 hasConcept C147789679 @default.
• W2891929410 hasConcept C150903083 @default.
• W2891929410 hasConcept C178790620 @default.
• W2891929410 hasConcept C185592680 @default.
• W2891929410 hasConcept C187530423 @default.
• W2891929410 hasConcept C207001950 @default.
• W2891929410 hasConcept C2776359302 @default.
• W2891929410 hasConcept C2776442465 @default.
• W2891929410 hasConcept C2778123984 @default.
• W2891929410 hasConcept C2778162923 @default.
• W2891929410 hasConcept C42219234 @default.
• W2891929410 hasConcept C43617362 @default.
• W2891929410 hasConcept C71924100 @default.
• W2891929410 hasConcept C86803240 @default.
• W2891929410 hasConceptScore W2891929410C11432220 @default.
• W2891929410 hasConceptScore W2891929410C147789679 @default.
• W2891929410 hasConceptScore W2891929410C150903083 @default.
• W2891929410 hasConceptScore W2891929410C178790620 @default.
• W2891929410 hasConceptScore W2891929410C185592680 @default.
• W2891929410 hasConceptScore W2891929410C187530423 @default.
• W2891929410 hasConceptScore W2891929410C207001950 @default.
• W2891929410 hasConceptScore W2891929410C2776359302 @default.
• W2891929410 hasConceptScore W2891929410C2776442465 @default.
• W2891929410 hasConceptScore W2891929410C2778123984 @default.
• W2891929410 hasConceptScore W2891929410C2778162923 @default.
• W2891929410 hasConceptScore W2891929410C42219234 @default.
• W2891929410 hasConceptScore W2891929410C43617362 @default.
• W2891929410 hasConceptScore W2891929410C71924100 @default.
• W2891929410 hasConceptScore W2891929410C86803240 @default.
• W2891929410 hasLocation W28919294101 @default.

• next