FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891930358> ?p ?o ?g. }

• W2891930358 abstract "Innate immune cells are responsible for the front line of host defense against pathogens and now appear to have a range of non-infectious roles as well, especially in cancer. Establishing the balance of innate immune responses is critical for the ‘flavor’ of these responses and subsequent adaptive immunity and can be either ‘good’ or ‘bad’ in controlling cancer progression. The importance of innate lymphocytic NK cells in tumor immune responses has already been extensively studied in the last few decades, but more recently several relatively oligo-clonal or semi-invariant innate T cells received substantial interest in tumor immunology, including invariant natural killer T (iNKT), γδ-T and mucosa associated invariant T (MAIT) cells. These subsets produce high levels of various pro- and/or anti- inflammatory cytokines/chemokines, reflecting their capacity to suppress or stimulate immune responses. Cancer patient survival has been linked to NK, iNKT and γδ-T cell activity and these innate subsets as well as MAIT cells have physiological roles in anti- tumor responses, emphasizing their relevance in tumor immunity. A variety of clinical trials has focused on manipulating NK, iNKT and γδ-T cell functions as a cancer immunotherapeutic approach demonstrating their safety and potential for achieving benecial therapeutic effects, while implications for MAIT cell-related therapies are still in their infancy. Current issues limiting the full therapeutic potential of these innate cell subsets appear to be related to (e.g.) defects and suppressive properties of these subsets that, with the right stimulus, might be reversed. In general, how innate lymphocytes are activated appears to control their subsequent abilities and consequent impact on adaptive immunity. Controlling these potent ‘Special Forces’ of the immune system should enable their protective roles to dominate and their deleterious potential (in the specific context of cancer or other diseases) to be mitigated." @default.
• W2891930358 created "2018-09-27" @default.
• W2891930358 creator A5009217310 @default.
• W2891930358 creator A5013858600 @default.
• W2891930358 creator A5019377810 @default.
• W2891930358 creator A5039412904 @default.
• W2891930358 creator A5048122449 @default.
• W2891930358 date "2018-09-21" @default.
• W2891930358 modified "2023-10-06" @default.
• W2891930358 title "Positive & Negative Roles of Innate Effector Cells in Controlling Cancer Progression" @default.
• W2891930358 cites W1261949646 @default.
• W2891930358 cites W1485226010 @default.
• W2891930358 cites W1487816967 @default.
• W2891930358 cites W1492322782 @default.
• W2891930358 cites W1495950501 @default.
• W2891930358 cites W1538328956 @default.
• W2891930358 cites W1538607209 @default.
• W2891930358 cites W1538826344 @default.
• W2891930358 cites W1570517267 @default.
• W2891930358 cites W1596821375 @default.
• W2891930358 cites W1607025084 @default.
• W2891930358 cites W1611736319 @default.
• W2891930358 cites W1642873092 @default.
• W2891930358 cites W1653601387 @default.
• W2891930358 cites W1674967027 @default.
• W2891930358 cites W1678468169 @default.
• W2891930358 cites W1819362717 @default.
• W2891930358 cites W188230809 @default.
• W2891930358 cites W1894308601 @default.
• W2891930358 cites W1919305622 @default.
• W2891930358 cites W1920167267 @default.
• W2891930358 cites W1955625177 @default.
• W2891930358 cites W1957245242 @default.
• W2891930358 cites W1963939177 @default.
• W2891930358 cites W1964982854 @default.
• W2891930358 cites W1966388729 @default.
• W2891930358 cites W1972494701 @default.
• W2891930358 cites W1972814015 @default.
• W2891930358 cites W1976690411 @default.
• W2891930358 cites W1976772617 @default.
• W2891930358 cites W1979775035 @default.
• W2891930358 cites W1981700081 @default.
• W2891930358 cites W1982680586 @default.
• W2891930358 cites W1983091225 @default.
• W2891930358 cites W1989322067 @default.
• W2891930358 cites W1993786192 @default.
• W2891930358 cites W1995224930 @default.
• W2891930358 cites W1995529916 @default.
• W2891930358 cites W1995930566 @default.
• W2891930358 cites W2000543898 @default.
• W2891930358 cites W2002197941 @default.
• W2891930358 cites W2002801575 @default.
• W2891930358 cites W2005765588 @default.
• W2891930358 cites W2008164090 @default.
• W2891930358 cites W2011941338 @default.
• W2891930358 cites W2012310044 @default.
• W2891930358 cites W2013143312 @default.
• W2891930358 cites W2013224779 @default.
• W2891930358 cites W2016523043 @default.
• W2891930358 cites W2017288179 @default.
• W2891930358 cites W2019813857 @default.
• W2891930358 cites W2021152296 @default.
• W2891930358 cites W2021377837 @default.
• W2891930358 cites W2023082289 @default.
• W2891930358 cites W2025141198 @default.
• W2891930358 cites W2026859850 @default.
• W2891930358 cites W2027160668 @default.
• W2891930358 cites W2032060983 @default.
• W2891930358 cites W2034769339 @default.
• W2891930358 cites W2039959261 @default.
• W2891930358 cites W2041909243 @default.
• W2891930358 cites W2044311205 @default.
• W2891930358 cites W2049739427 @default.
• W2891930358 cites W2051218772 @default.
• W2891930358 cites W2052102821 @default.
• W2891930358 cites W2052502668 @default.
• W2891930358 cites W2053767177 @default.
• W2891930358 cites W2058222130 @default.
• W2891930358 cites W2059229059 @default.
• W2891930358 cites W2061699947 @default.
• W2891930358 cites W2062719961 @default.
• W2891930358 cites W2063192133 @default.
• W2891930358 cites W2064229689 @default.
• W2891930358 cites W2064858323 @default.
• W2891930358 cites W2064920472 @default.
• W2891930358 cites W2065252029 @default.
• W2891930358 cites W2065363863 @default.
• W2891930358 cites W2067754261 @default.
• W2891930358 cites W2070780262 @default.
• W2891930358 cites W2071742694 @default.
• W2891930358 cites W2073312795 @default.
• W2891930358 cites W2074612105 @default.
• W2891930358 cites W2078056828 @default.
• W2891930358 cites W2079068389 @default.
• W2891930358 cites W2080933544 @default.
• W2891930358 cites W2084848633 @default.
• W2891930358 cites W2087103155 @default.
• W2891930358 cites W2087133492 @default.
• W2891930358 cites W2087510980 @default.
• W2891930358 cites W2088513299 @default.

• next