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- W2891931404 abstract "Background: Cystic Fibrosis (CF), one of the most frequent genetic diseases, is characterized by the production of viscous mucus in several organs. In the lungs, mucus clogs the airways and traps bacteria, leading to recurrent/resistant infections and lung damage. For cystic fibrosis patients, respiratory failure is still lethal in early adulthood since available treatments display incomplete efficacy. Objective: The objective of this review is to extend the current knowledge in the field of available treatments for cystic fibrosis. A special focus has been given to inhaled peptide-based drugs. Methods: The current review is based on recent and/or relevant literature and patents already available in various scientific databases, which include PubMed, PubMed Central, Patentscope and Science Direct. The information obtained through these diverse databases is compiled, critically interpreted and presented in the current study. An in-depth but not systematic approach to the specific research question has been adopted. Results: Recently, peptides have been proposed as possible pharmacologic agents for the treatment of respiratory diseases. Of note, peptides are suitable to be administered by inhalation to maximize efficacy and reduce systemic side effects. Moreover, innovative delivery carriers have been developed for drug administration through inhalation, allowing not only protection against proteolysis, but also a prolonged and controlled release. Conclusion: Here, we summarize newly patented peptides that have been developed in the last few years and advanced technologies for inhaled drug delivery to treat cystic fibrosis." @default.
- W2891931404 created "2018-09-27" @default.
- W2891931404 creator A5036774363 @default.
- W2891931404 creator A5038307963 @default.
- W2891931404 creator A5046392248 @default.
- W2891931404 date "2019-08-05" @default.
- W2891931404 modified "2023-10-11" @default.
- W2891931404 title "Inhaled Biologicals for the Treatment of Cystic Fibrosis" @default.
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- W2891931404 doi "https://doi.org/10.2174/1872213x12666181012101444" @default.
- W2891931404 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6751348" @default.
- W2891931404 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30318010" @default.
- W2891931404 hasPublicationYear "2019" @default.
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