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• W2891932262 abstract "N-glycosylation is a post-translational modification that occurs in all three domains. In Archaea, however, N-linked glycans present a degree of compositional diversity not observed in either Eukarya or Bacteria. As such, it is surprising that nonulosonic acids (NulOs), nine-carbon sugars that include sialic acids, pseudaminic acids, and legionaminic acids, are routinely detected as components of protein-linked glycans in Eukarya and Bacteria but not in Archaea. In the following, we report that the N-linked glycan attached to the S-layer glycoprotein of the haloarchaea Halorubrum sp. PV6 includes an N-formylated legionaminic acid. Analysis of the Halorubrum sp. PV6 genome led to the identification of sequences predicted to comprise the legionaminic acid biosynthesis pathway. The transcription of pathway genes was confirmed, as was the co-transcription of several of these genes. In addition, the activities of LegI, which catalyzes the condensation of 2,4-di-N-acetyl-6-deoxymannose and phosphoenolpyruvate to generate legionaminic acid, and LegF, which catalyzes the addition of cytidine monophosphate (CMP) to legionaminic acid, both heterologously expressed in Haloferax volcanii, were demonstrated. Further genome analysis predicts that the genes encoding enzymes of the legionaminic acid biosynthetic pathway are clustered together with sequences seemingly encoding components of the N-glycosylation pathway in this organism. In defining the first example of a legionaminic acid biosynthesis pathway in Archaea, the findings reported here expand our insight into archaeal N-glycosylation, an almost universal post-translational modification in this domain of life." @default.
• W2891932262 created "2018-09-27" @default.
• W2891932262 creator A5004805143 @default.
• W2891932262 creator A5023221161 @default.
• W2891932262 creator A5068675136 @default.
• W2891932262 date "2018-09-07" @default.
• W2891932262 modified "2023-10-12" @default.
• W2891932262 title "Sialic Acid-Like Sugars in Archaea: Legionaminic Acid Biosynthesis in the Halophile Halorubrum sp. PV6" @default.
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• W2891932262 doi "https://doi.org/10.3389/fmicb.2018.02133" @default.
• W2891932262 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6137143" @default.
• W2891932262 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30245679" @default.
• W2891932262 hasPublicationYear "2018" @default.
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