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- W2891935587 abstract "Background: Surgical cancer margin status affects prognosis. Negative margins may be impossible if tumor abuts vascular structures. We created a novel device to produce lethal heating in cancers abutting major blood vessels without causing thrombosis. Methods: We modeled pancreatic adenocarcinoma (PDAC) because it may involve the superior mesenteric artery (SMA). Human PDAC received hyperthermia in an orthotopic model to determine thermal sensitivity. We built devices to produce heat to the arterial wall without occlusion. These devices were tested using the femoral artery or SMA of swine. Results: Tests with human PDAC cells established 46 °CC for 10 minutes as the temperature and time to kill PDAC cells without killing normal cells. Femoral artery studies showed 46 °C for 10 minutes on the outer wall was associated with 2 °CC lower temperature in the lumen. Treatment of the SMA caused no occlusion or bowel injury, and the vessel was patent 48 hours after treatment. Conclusion: We demonstrated a surgical device can produce temperatures sufficient to kill cancer cells involving critical arteries and not cause endothelial damage or vascular thrombosis. Additional studies will confirm there is no subacute or chronic arterial injury or issues with bowel perfusion." @default.
- W2891935587 created "2018-09-27" @default.
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- W2891935587 date "2018-03-01" @default.
- W2891935587 modified "2023-10-16" @default.
- W2891935587 title "The intersection of surgery and bioengineering: innovative solutions for clinical problems in pancreatic and other cancers" @default.
- W2891935587 doi "https://doi.org/10.1016/j.hpb.2018.02.298" @default.
- W2891935587 hasPublicationYear "2018" @default.
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