Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891936075> ?p ?o ?g. }
- W2891936075 endingPage "154" @default.
- W2891936075 startingPage "143" @default.
- W2891936075 abstract "Autologous nerve grafts are the current “gold standard” for repairing large nerve gaps. However, they cause morbidity at the donor nerve site and only a limited amount of nerve can be harvested. Nerve conduits are a promising alternative to autografts and can act as guidance cues for the regenerating axons, without the need to harvest donor nerve. Separately, it has been shown that localized delivery of GDNF can enhance axon growth and motor recovery. FK506, an FDA approved small molecule, has also been shown to enhance peripheral nerve regeneration. This paper describes the design of a novel hole-based drug delivery apparatus integrated with a polytetrafluoroethylene (PTFE) nerve conduit for controlled local delivery of a protein such as GDNF or a small molecule such as FK506. The PTFE devices were tested in a diffusion chamber, and the bioactivity of the released media was evaluated by measuring neurite growth of dorsal root ganglions (DRGs) exposed to the released drugs. The drug delivering nerve guide was able to release bioactive concentrations of FK506 or GDNF. Following these tests, optimized drug releasing nerve conduits were implanted across 10 mm sciatic nerve gaps in a BL6 yellow fluorescent protein (YFP) mouse model, where they demonstrated significant improvement in muscle mass, compound muscle action potential, and axon myelination in vivo as compared with nerve conduits without the drug. The drug delivery nerve guide could release drug for extended periods of time and enhance axon growth in vitro and in vivo." @default.
- W2891936075 created "2018-09-27" @default.
- W2891936075 creator A5004823813 @default.
- W2891936075 creator A5016377432 @default.
- W2891936075 creator A5019679217 @default.
- W2891936075 creator A5031065617 @default.
- W2891936075 creator A5041457976 @default.
- W2891936075 creator A5055732792 @default.
- W2891936075 creator A5056101193 @default.
- W2891936075 creator A5066534077 @default.
- W2891936075 date "2018-10-27" @default.
- W2891936075 modified "2023-10-17" @default.
- W2891936075 title "Drug‐delivering nerve conduit improves regeneration in a critical‐sized gap" @default.
- W2891936075 cites W1492349549 @default.
- W2891936075 cites W1604133550 @default.
- W2891936075 cites W1856059914 @default.
- W2891936075 cites W1968531253 @default.
- W2891936075 cites W1971968937 @default.
- W2891936075 cites W1976023205 @default.
- W2891936075 cites W1981223600 @default.
- W2891936075 cites W1983353068 @default.
- W2891936075 cites W1988001149 @default.
- W2891936075 cites W1989381407 @default.
- W2891936075 cites W1990922607 @default.
- W2891936075 cites W1991882747 @default.
- W2891936075 cites W1993896968 @default.
- W2891936075 cites W1994285731 @default.
- W2891936075 cites W1994562506 @default.
- W2891936075 cites W2003137746 @default.
- W2891936075 cites W2013303704 @default.
- W2891936075 cites W2022756809 @default.
- W2891936075 cites W2026874993 @default.
- W2891936075 cites W2029791880 @default.
- W2891936075 cites W2029893976 @default.
- W2891936075 cites W2037648324 @default.
- W2891936075 cites W2039253350 @default.
- W2891936075 cites W2039690264 @default.
- W2891936075 cites W2057611119 @default.
- W2891936075 cites W2071842958 @default.
- W2891936075 cites W2082417516 @default.
- W2891936075 cites W2084857658 @default.
- W2891936075 cites W2086534450 @default.
- W2891936075 cites W2094192363 @default.
- W2891936075 cites W2094724619 @default.
- W2891936075 cites W2101173835 @default.
- W2891936075 cites W2104950498 @default.
- W2891936075 cites W2110674840 @default.
- W2891936075 cites W2116356198 @default.
- W2891936075 cites W2120002445 @default.
- W2891936075 cites W2120666858 @default.
- W2891936075 cites W2133966135 @default.
- W2891936075 cites W2135128039 @default.
- W2891936075 cites W2136511265 @default.
- W2891936075 cites W2139565721 @default.
- W2891936075 cites W2141734316 @default.
- W2891936075 cites W2142254746 @default.
- W2891936075 cites W2162892919 @default.
- W2891936075 cites W2163789638 @default.
- W2891936075 cites W2165716325 @default.
- W2891936075 cites W2169523708 @default.
- W2891936075 cites W2170956454 @default.
- W2891936075 cites W2171390081 @default.
- W2891936075 cites W2267051237 @default.
- W2891936075 cites W2419411847 @default.
- W2891936075 cites W2510757592 @default.
- W2891936075 cites W2582407774 @default.
- W2891936075 cites W4239438659 @default.
- W2891936075 cites W85322626 @default.
- W2891936075 doi "https://doi.org/10.1002/bit.26837" @default.
- W2891936075 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30229866" @default.
- W2891936075 hasPublicationYear "2018" @default.
- W2891936075 type Work @default.
- W2891936075 sameAs 2891936075 @default.
- W2891936075 citedByCount "21" @default.
- W2891936075 countsByYear W28919360752019 @default.
- W2891936075 countsByYear W28919360752020 @default.
- W2891936075 countsByYear W28919360752021 @default.
- W2891936075 countsByYear W28919360752022 @default.
- W2891936075 countsByYear W28919360752023 @default.
- W2891936075 crossrefType "journal-article" @default.
- W2891936075 hasAuthorship W2891936075A5004823813 @default.
- W2891936075 hasAuthorship W2891936075A5016377432 @default.
- W2891936075 hasAuthorship W2891936075A5019679217 @default.
- W2891936075 hasAuthorship W2891936075A5031065617 @default.
- W2891936075 hasAuthorship W2891936075A5041457976 @default.
- W2891936075 hasAuthorship W2891936075A5055732792 @default.
- W2891936075 hasAuthorship W2891936075A5056101193 @default.
- W2891936075 hasAuthorship W2891936075A5066534077 @default.
- W2891936075 hasBestOaLocation W28919360751 @default.
- W2891936075 hasConcept C105702510 @default.
- W2891936075 hasConcept C113246987 @default.
- W2891936075 hasConcept C126322002 @default.
- W2891936075 hasConcept C136229726 @default.
- W2891936075 hasConcept C136940099 @default.
- W2891936075 hasConcept C150903083 @default.
- W2891936075 hasConcept C160539049 @default.
- W2891936075 hasConcept C170493617 @default.
- W2891936075 hasConcept C171056886 @default.