Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891936243> ?p ?o ?g. }
- W2891936243 abstract "Marburg virus (MARV; family Filoviridae) causes sporadic outbreaks of Marburg hemorrhagic fever in sub-Saharan Africa with case fatality rates reaching 90%. Wild-type filoviruses, including MARV and the closely related Ebola virus, are unable to suppress the type I interferon response in rodents, and therefore require adaptation of the viruses to cause disease in immunocompetent animals. In the current study, we demonstrate that STAT2 knockout Syrian hamsters are susceptible to infection with different wild-type MARV variants. MARV Musoke causes a robust and systemic infection resulting in lethal disease. Histopathological findings share features similar to those observed in human patients and other animal models of filovirus infection. Reverse-transcription polymerase chain reaction analysis of host transcripts shows a dysregulation of the innate immune response. Our results demonstrate that the STAT2 knockout hamster represents a novel small animal model of severe MARV infection and disease without the requirement for virus adaptation." @default.
- W2891936243 created "2018-09-27" @default.
- W2891936243 creator A5008961608 @default.
- W2891936243 creator A5010821923 @default.
- W2891936243 creator A5016562815 @default.
- W2891936243 creator A5034055198 @default.
- W2891936243 creator A5040788314 @default.
- W2891936243 creator A5047557434 @default.
- W2891936243 creator A5051788465 @default.
- W2891936243 creator A5057057095 @default.
- W2891936243 creator A5071077931 @default.
- W2891936243 creator A5080818026 @default.
- W2891936243 creator A5081012039 @default.
- W2891936243 creator A5081327494 @default.
- W2891936243 date "2018-09-06" @default.
- W2891936243 modified "2023-09-27" @default.
- W2891936243 title "Natural History and Pathogenesis of Wild-Type Marburg Virus Infection in STAT2 Knockout Hamsters" @default.
- W2891936243 cites W1266297804 @default.
- W2891936243 cites W1781829305 @default.
- W2891936243 cites W1830939273 @default.
- W2891936243 cites W1892150725 @default.
- W2891936243 cites W1937339698 @default.
- W2891936243 cites W1971350188 @default.
- W2891936243 cites W1978279817 @default.
- W2891936243 cites W1982448036 @default.
- W2891936243 cites W2004044377 @default.
- W2891936243 cites W2004688512 @default.
- W2891936243 cites W2011910693 @default.
- W2891936243 cites W2034509139 @default.
- W2891936243 cites W2049320958 @default.
- W2891936243 cites W2079928928 @default.
- W2891936243 cites W2081913810 @default.
- W2891936243 cites W2082882388 @default.
- W2891936243 cites W2095977073 @default.
- W2891936243 cites W2100021633 @default.
- W2891936243 cites W2100997544 @default.
- W2891936243 cites W2109152434 @default.
- W2891936243 cites W2110608820 @default.
- W2891936243 cites W2111739562 @default.
- W2891936243 cites W2115723034 @default.
- W2891936243 cites W2121706409 @default.
- W2891936243 cites W2121895001 @default.
- W2891936243 cites W2144836333 @default.
- W2891936243 cites W2152930926 @default.
- W2891936243 cites W2154496316 @default.
- W2891936243 cites W2162445773 @default.
- W2891936243 cites W2162465239 @default.
- W2891936243 cites W2163858364 @default.
- W2891936243 cites W2175122451 @default.
- W2891936243 cites W2289309620 @default.
- W2891936243 cites W2320122886 @default.
- W2891936243 cites W2336846987 @default.
- W2891936243 cites W2553062031 @default.
- W2891936243 cites W2561981787 @default.
- W2891936243 cites W2606622106 @default.
- W2891936243 cites W2613279231 @default.
- W2891936243 cites W2725760085 @default.
- W2891936243 cites W2752077543 @default.
- W2891936243 cites W4320995993 @default.
- W2891936243 doi "https://doi.org/10.1093/infdis/jiy457" @default.
- W2891936243 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6249581" @default.
- W2891936243 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30192975" @default.
- W2891936243 hasPublicationYear "2018" @default.
- W2891936243 type Work @default.
- W2891936243 sameAs 2891936243 @default.
- W2891936243 citedByCount "10" @default.
- W2891936243 countsByYear W28919362432019 @default.
- W2891936243 countsByYear W28919362432020 @default.
- W2891936243 countsByYear W28919362432021 @default.
- W2891936243 countsByYear W28919362432022 @default.
- W2891936243 countsByYear W28919362432023 @default.
- W2891936243 crossrefType "journal-article" @default.
- W2891936243 hasAuthorship W2891936243A5008961608 @default.
- W2891936243 hasAuthorship W2891936243A5010821923 @default.
- W2891936243 hasAuthorship W2891936243A5016562815 @default.
- W2891936243 hasAuthorship W2891936243A5034055198 @default.
- W2891936243 hasAuthorship W2891936243A5040788314 @default.
- W2891936243 hasAuthorship W2891936243A5047557434 @default.
- W2891936243 hasAuthorship W2891936243A5051788465 @default.
- W2891936243 hasAuthorship W2891936243A5057057095 @default.
- W2891936243 hasAuthorship W2891936243A5071077931 @default.
- W2891936243 hasAuthorship W2891936243A5080818026 @default.
- W2891936243 hasAuthorship W2891936243A5081012039 @default.
- W2891936243 hasAuthorship W2891936243A5081327494 @default.
- W2891936243 hasBestOaLocation W28919362431 @default.
- W2891936243 hasConcept C104317684 @default.
- W2891936243 hasConcept C136449434 @default.
- W2891936243 hasConcept C159047783 @default.
- W2891936243 hasConcept C182704531 @default.
- W2891936243 hasConcept C203014093 @default.
- W2891936243 hasConcept C2522874641 @default.
- W2891936243 hasConcept C2776178377 @default.
- W2891936243 hasConcept C2777245867 @default.
- W2891936243 hasConcept C2777469322 @default.
- W2891936243 hasConcept C2780727368 @default.
- W2891936243 hasConcept C2780813555 @default.
- W2891936243 hasConcept C2910190370 @default.
- W2891936243 hasConcept C54355233 @default.
- W2891936243 hasConcept C86803240 @default.
- W2891936243 hasConcept C8891405 @default.