FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891936347> ?p ?o ?g. }

• W2891936347 abstract "The etiology of age-related olfactory loss is still unclear, but it has been claimed that polypharmacotherapy may contribute to olfactory dysfunction, particularly in the elderly, who are more likely to need multiple drugs. The present pilot study investigated the relationship between smell and the number and type of drugs taken in a group of elderly.50 elderly volunteers (over 64 years old) who were healthy from the sinonasal standpoint (SNOT-22 under 1) and had no cognitive impairments [Mini Mental State Examination (MMSE over 18) were administered the Screening 12 test and tested on their n-butanol olfactory threshold. Their olfactory performance was then connected with the number and type of drugs participants used.The mean age of the included volunteers was 74 plus/minus 7 years. No association emerged between odor identification and number of drugs taken. The number of drugs taken correlated directly with a worse olfactory threshold and with a worse MMSE score, meaning a worse cognitive status. Odor identification significantly worsened with age. Comparing those volunteers taking only one drug known to not influence olfaction with another sub-group of volunteers taking five or more drugs, it was evident that subjects taking only one drug scored significantly better in olfactory threshold test and MMSE, and marginally better in olfactory identification test. For what concerns the difference between male and female volunteers, no difference in olfactory test result was shown, both for threshold and identification. Univariate analysis showed a direct correlation between the consumption of calcium channel blockers, beta-blockers, acetylsalicylic acid and olfactory threshold, meaning a worse sense of smell. Acetylsalicylic acid also correlated inversely with odor identification, meaning again a worse sense of smell, and so did potassium-sparing diuretics. Multivariate analysis showed that MMSE scores correlated with a better sense of smell, that is a lower olfactory threshold, and that beta-blockers and acetylsalicylic acid negatively affected olfactory threshold, meaning a worse sense of smell. Acetylsalicylic acid also correlated inversely with odor identification, meaning again a worse sense of smell.The number of drugs taken demonstrated to be significantly correlated with a worse olfactory threshold and worse MMSE. Larger studies on elderly volunteers are needed to confirm these preliminary findings." @default.
• W2891936347 created "2018-09-27" @default.
• W2891936347 creator A5015850975 @default.
• W2891936347 creator A5021185284 @default.
• W2891936347 creator A5027351444 @default.
• W2891936347 creator A5040984253 @default.
• W2891936347 creator A5057612534 @default.
• W2891936347 creator A5058663136 @default.
• W2891936347 creator A5061295209 @default.
• W2891936347 creator A5075683637 @default.
• W2891936347 creator A5088506689 @default.
• W2891936347 date "2018-09-01" @default.
• W2891936347 modified "2023-10-16" @default.
• W2891936347 title "Influence of number of drugs on olfaction in the elderly" @default.
• W2891936347 doi "https://doi.org/10.4193/rhin17.152" @default.
• W2891936347 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29938715" @default.
• W2891936347 hasPublicationYear "2018" @default.
• W2891936347 type Work @default.
• W2891936347 sameAs 2891936347 @default.
• W2891936347 citedByCount "7" @default.
• W2891936347 countsByYear W28919363472019 @default.
• W2891936347 countsByYear W28919363472020 @default.
• W2891936347 countsByYear W28919363472021 @default.
• W2891936347 countsByYear W28919363472022 @default.
• W2891936347 countsByYear W28919363472023 @default.
• W2891936347 crossrefType "journal-article" @default.
• W2891936347 hasAuthorship W2891936347A5015850975 @default.
• W2891936347 hasAuthorship W2891936347A5021185284 @default.
• W2891936347 hasAuthorship W2891936347A5027351444 @default.
• W2891936347 hasAuthorship W2891936347A5040984253 @default.
• W2891936347 hasAuthorship W2891936347A5057612534 @default.
• W2891936347 hasAuthorship W2891936347A5058663136 @default.
• W2891936347 hasAuthorship W2891936347A5061295209 @default.
• W2891936347 hasAuthorship W2891936347A5075683637 @default.
• W2891936347 hasAuthorship W2891936347A5088506689 @default.
• W2891936347 hasBestOaLocation W28919363471 @default.
• W2891936347 hasConcept C118552586 @default.
• W2891936347 hasConcept C126322002 @default.
• W2891936347 hasConcept C137627325 @default.
• W2891936347 hasConcept C144301174 @default.
• W2891936347 hasConcept C15744967 @default.
• W2891936347 hasConcept C163214680 @default.
• W2891936347 hasConcept C169760540 @default.
• W2891936347 hasConcept C201792869 @default.
• W2891936347 hasConcept C38180746 @default.
• W2891936347 hasConcept C548259974 @default.
• W2891936347 hasConcept C71924100 @default.
• W2891936347 hasConceptScore W2891936347C118552586 @default.
• W2891936347 hasConceptScore W2891936347C126322002 @default.
• W2891936347 hasConceptScore W2891936347C137627325 @default.
• W2891936347 hasConceptScore W2891936347C144301174 @default.
• W2891936347 hasConceptScore W2891936347C15744967 @default.
• W2891936347 hasConceptScore W2891936347C163214680 @default.
• W2891936347 hasConceptScore W2891936347C169760540 @default.
• W2891936347 hasConceptScore W2891936347C201792869 @default.
• W2891936347 hasConceptScore W2891936347C38180746 @default.
• W2891936347 hasConceptScore W2891936347C548259974 @default.
• W2891936347 hasConceptScore W2891936347C71924100 @default.
• W2891936347 hasLocation W28919363471 @default.
• W2891936347 hasLocation W28919363472 @default.
• W2891936347 hasOpenAccess W2891936347 @default.
• W2891936347 hasPrimaryLocation W28919363471 @default.
• W2891936347 hasRelatedWork W1604775504 @default.
• W2891936347 hasRelatedWork W1979901062 @default.
• W2891936347 hasRelatedWork W2070075829 @default.
• W2891936347 hasRelatedWork W2159289603 @default.
• W2891936347 hasRelatedWork W2160773722 @default.
• W2891936347 hasRelatedWork W3093357287 @default.
• W2891936347 hasRelatedWork W3094970719 @default.
• W2891936347 hasRelatedWork W4212789871 @default.
• W2891936347 hasRelatedWork W4281611465 @default.
• W2891936347 hasRelatedWork W85177372 @default.
• W2891936347 isParatext "false" @default.
• W2891936347 isRetracted "false" @default.
• W2891936347 magId "2891936347" @default.
• W2891936347 workType "article" @default.