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• W2891937032 startingPage "e0202656" @default.
• W2891937032 abstract "CD43 is a large transmembrane protein involved in T cell activation. Previous studies of CD43-/- mice in viral models have demonstrated a role for CD43 in Th1/Th2 skewing, activation of Foxp3+ Treg, and T cell apoptosis. However, the role of CD43 during sepsis has never been tested. Thus, we interrogated the role of CD43 during sepsis using a murine cecal ligation and puncture (CLP) model, and found that CD43-/- mice demonstrated significantly worsened mortality compared to B6 mice following CLP. Phenotypic analysis of splenocytes isolated 24 h after septic insult revealed significantly increased apoptosis of central memory cells in both CD4+ and CD8+ T cell compartments in CD43-/- septic mice compared to WT septic mice. Furthermore, CD43-/-septic mice exhibited a prominent Th2 skewing following sepsis relative to WT septic mice, as evidenced by a significant decrease in the frequency of IL-2+ CXCR3+ TH1 cells as a significant increase in the frequency of IL-4+ CCR4+ TH2 cells. Finally, septic CD43-/- animals contained significantly fewer CD25+ Foxp3+ TReg cells as compared to WT septic animals. Importantly, depleting CD25+ Treg eliminated the increased mortality observed in CD43-/- mice. Taken together, these data demonstrate an important role of CD43 in modulating immune dysregulation and mortality following sepsis." @default.
• W2891937032 created "2018-09-27" @default.
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• W2891937032 date "2018-09-18" @default.
• W2891937032 modified "2023-09-30" @default.
• W2891937032 title "Increased mortality in CD43-deficient mice during sepsis" @default.
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• W2891937032 doi "https://doi.org/10.1371/journal.pone.0202656" @default.
• W2891937032 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6143188" @default.
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