FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891937265> ?p ?o ?g. }

• W2891937265 abstract "Background: Novel anticoagulants NOACS dabigatran DABI rivaroxaban RIVA and apixaban APIX do not require routine monitoring. There are situations where monitoring would be useful including bleedings, trauma, and thromboembolic events while on anticoagulation. The aim of this in vivo study was to assess the anticoagulant effect of NOACS with novel modified TEG assay containing ecarin and factor Xa concentrate. Methods: 9 healthy male volunteers were given single dose of oral DABI 150mg or RIVA 20mg or APIX 5mg and were phlebotomized at 0, 1 and 3 hours after intake of NOAC. Reaction time R was measured using TEG®5000. Concentrations (conc.) of DABI, RIVA and APIX were measured using chromogenic assay Biophen® DTI and DiXaI. Based on available literature on pharmacokinetics of NOACS, clinical range for each agent was estimated. The R values was correlated to the drug conc. and sensitivity SN, specificity SP, positive and negative predictive values (PPV&NPV) for the minimum therapeutic range of each agent was calculated. Results: Using Ecarin assay, R was highly correlated with DABI conc. r = 0.96, p < 0.0001. R value of >5.7 had 88% SN 100% SP, 100% PPV and 95% NPV for DABI conc. of >50ng/ml. Using Factor Xa assay, R was highly correlated with RIVA conc. r = 0.89, p < 0.0001. R value of >4.8 had 94% SN, 100% SP, 100% PPV, and 92% NPV for RIVA conc. of >100ng/ml. Using Factor Xa assay R was highly correlated with APIX conc. r = 0.86, p < 0.0001. R value of >4.3 had 93% SN, 100% SP, 100 PPV and 93% NPV for APIX conc. of >50ng/ml. Conclusion: We have for the first time demonstrated that TEG® point-of-care device can monitor the NOACS effect on the hemostasis with highly significant correlation with the drug levels of each agent. This novel technology is easy to use on whole blood without need for specialized expertise. Larger clinical studies are warranted for correlation of TEG findings and clinical outcome." @default.
• W2891937265 created "2018-09-27" @default.
• W2891937265 creator A5062792548 @default.
• W2891937265 creator A5074193003 @default.
• W2891937265 creator A5088006074 @default.
• W2891937265 date "2015-11-10" @default.
• W2891937265 modified "2023-09-25" @default.
• W2891937265 title "Abstract 17582: Monitoring Novel Anticoagulants Dabigatron, Rivaroxaban and Apixaban Using Modified Thrombelastography" @default.
• W2891937265 doi "https://doi.org/10.1161/circ.132.suppl_3.17582" @default.
• W2891937265 hasPublicationYear "2015" @default.
• W2891937265 type Work @default.
• W2891937265 sameAs 2891937265 @default.
• W2891937265 citedByCount "0" @default.
• W2891937265 crossrefType "journal-article" @default.
• W2891937265 hasAuthorship W2891937265A5062792548 @default.
• W2891937265 hasAuthorship W2891937265A5074193003 @default.
• W2891937265 hasAuthorship W2891937265A5088006074 @default.
• W2891937265 hasConcept C126322002 @default.
• W2891937265 hasConcept C2776301958 @default.
• W2891937265 hasConcept C2778382381 @default.
• W2891937265 hasConcept C2778661090 @default.
• W2891937265 hasConcept C2778810321 @default.
• W2891937265 hasConcept C2779161974 @default.
• W2891937265 hasConcept C2780638905 @default.
• W2891937265 hasConcept C2910686401 @default.
• W2891937265 hasConcept C71924100 @default.
• W2891937265 hasConcept C98274493 @default.
• W2891937265 hasConceptScore W2891937265C126322002 @default.
• W2891937265 hasConceptScore W2891937265C2776301958 @default.
• W2891937265 hasConceptScore W2891937265C2778382381 @default.
• W2891937265 hasConceptScore W2891937265C2778661090 @default.
• W2891937265 hasConceptScore W2891937265C2778810321 @default.
• W2891937265 hasConceptScore W2891937265C2779161974 @default.
• W2891937265 hasConceptScore W2891937265C2780638905 @default.
• W2891937265 hasConceptScore W2891937265C2910686401 @default.
• W2891937265 hasConceptScore W2891937265C71924100 @default.
• W2891937265 hasConceptScore W2891937265C98274493 @default.
• W2891937265 hasIssue "suppl_3" @default.
• W2891937265 hasLocation W28919372651 @default.
• W2891937265 hasOpenAccess W2891937265 @default.
• W2891937265 hasPrimaryLocation W28919372651 @default.
• W2891937265 hasRelatedWork W110720902 @default.
• W2891937265 hasRelatedWork W1980555552 @default.
• W2891937265 hasRelatedWork W2160586820 @default.
• W2891937265 hasRelatedWork W2321100207 @default.
• W2891937265 hasRelatedWork W2602745543 @default.
• W2891937265 hasRelatedWork W2789972226 @default.
• W2891937265 hasRelatedWork W2811048362 @default.
• W2891937265 hasRelatedWork W3107582387 @default.
• W2891937265 hasRelatedWork W3198203860 @default.
• W2891937265 hasRelatedWork W1570353559 @default.
• W2891937265 hasVolume "132" @default.
• W2891937265 isParatext "false" @default.
• W2891937265 isRetracted "false" @default.
• W2891937265 magId "2891937265" @default.
• W2891937265 workType "article" @default.