FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891937369> ?p ?o ?g. }

• W2891937369 endingPage "152" @default.
• W2891937369 startingPage "144" @default.
• W2891937369 abstract "Hypericum genus is traditionally known for its medicinal use and its therapeutic and antioxidant effects. However, the toxic effect of this plant has not been much explored. Our study aimed at investigating the effect of Hypericum humifusum (Hh) leaf extracts on oxidative stress parameters in male rats. For it, we first focused on the phytochemical analysis of the aqueous and methanolic extracts of Hh leaves. Hence, Wistar rats were treated per gavage for 30 days and divided into Control (1 mL/rat, distilled water), A200 group (200 mg/kg body weight (bw) aqueous extract), A400 group (400 mg/kg bw aqueous extract), M10 group (10 mg/kg bw methanolic extract), M20 group (20 mg/kg bw methanolic extract). The phytochemical analysis revealed the presence of tannins, flavonoids, steroids, carbohydrates, and phenolic compounds. Biochemical and histological investigations were performed in plasma and liver tissue. Liver tissue homogenates were used for the measurement of malondialdehyde (MDA), catalase (CAT) and superoxide dismutase (SOD) levels. At the same time, alanine transaminase (ALT), aspartate transaminase (AST) and lactate dehydrogenase (LDH) were assayed in plasma samples. Histological study was also conducted in liver. We showed that Hh extracts reduced relative liver weight and increased ALT, AST, LDH activities in treated groups compared to control group. These results were associated with an increase of MDA levels and a decrease of antioxidant enzyme activities (CAT and SOD) in liver tissues of treated rats. Histology of liver demonstrated several alterations showing necrosis, altered hepatocytes and lymphocyte migration mainly in A200 group and dilated sinusoids, foamy appearance of hepatocytes and lymphocyte accumulation in the other treated groups. This original work indicated that chronic consumption of Hh leaf extracts has no antioxidant effect but instead it induces oxidative stress and enhances markers of cell damage which was confirmed by histological study of liver rats." @default.
• W2891937369 created "2018-09-27" @default.
• W2891937369 creator A5020317025 @default.
• W2891937369 creator A5032248898 @default.
• W2891937369 creator A5034546440 @default.
• W2891937369 creator A5052529777 @default.
• W2891937369 creator A5058334596 @default.
• W2891937369 creator A5072098713 @default.
• W2891937369 date "2018-12-01" @default.
• W2891937369 modified "2023-10-14" @default.
• W2891937369 title "Effect of Hypericum humifusum aqueous and methanolic leaf extracts on biochemical and histological parameters in adult rats" @default.
• W2891937369 cites W1488521864 @default.
• W2891937369 cites W1590457525 @default.
• W2891937369 cites W191793640 @default.
• W2891937369 cites W1974604537 @default.
• W2891937369 cites W1975367953 @default.
• W2891937369 cites W1976941064 @default.
• W2891937369 cites W1978871608 @default.
• W2891937369 cites W1983925171 @default.
• W2891937369 cites W1993678941 @default.
• W2891937369 cites W2000877308 @default.
• W2891937369 cites W2002387355 @default.
• W2891937369 cites W2009674410 @default.
• W2891937369 cites W2012252741 @default.
• W2891937369 cites W2016896581 @default.
• W2891937369 cites W2019518180 @default.
• W2891937369 cites W2021426461 @default.
• W2891937369 cites W2027559330 @default.
• W2891937369 cites W2031971602 @default.
• W2891937369 cites W2051882869 @default.
• W2891937369 cites W2061774778 @default.
• W2891937369 cites W2066244195 @default.
• W2891937369 cites W2072970426 @default.
• W2891937369 cites W2075488370 @default.
• W2891937369 cites W2082208678 @default.
• W2891937369 cites W2083507399 @default.
• W2891937369 cites W2089206072 @default.
• W2891937369 cites W2093119448 @default.
• W2891937369 cites W2095744717 @default.
• W2891937369 cites W2104558985 @default.
• W2891937369 cites W2108176270 @default.
• W2891937369 cites W2108266732 @default.
• W2891937369 cites W2115692333 @default.
• W2891937369 cites W2123662806 @default.
• W2891937369 cites W2132693595 @default.
• W2891937369 cites W2140789801 @default.
• W2891937369 cites W2153361384 @default.
• W2891937369 cites W2307363824 @default.
• W2891937369 cites W2321700180 @default.
• W2891937369 cites W2583796122 @default.
• W2891937369 cites W2610871590 @default.
• W2891937369 cites W2617380585 @default.
• W2891937369 cites W4248176532 @default.
• W2891937369 cites W4293247451 @default.
• W2891937369 cites W746997374 @default.
• W2891937369 cites W2565335130 @default.
• W2891937369 doi "https://doi.org/10.1016/j.biopha.2018.09.034" @default.
• W2891937369 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30218859" @default.
• W2891937369 hasPublicationYear "2018" @default.
• W2891937369 type Work @default.
• W2891937369 sameAs 2891937369 @default.
• W2891937369 citedByCount "7" @default.
• W2891937369 countsByYear W28919373692019 @default.
• W2891937369 countsByYear W28919373692020 @default.
• W2891937369 countsByYear W28919373692021 @default.
• W2891937369 countsByYear W28919373692023 @default.
• W2891937369 crossrefType "journal-article" @default.
• W2891937369 hasAuthorship W2891937369A5020317025 @default.
• W2891937369 hasAuthorship W2891937369A5032248898 @default.
• W2891937369 hasAuthorship W2891937369A5034546440 @default.
• W2891937369 hasAuthorship W2891937369A5052529777 @default.
• W2891937369 hasAuthorship W2891937369A5058334596 @default.
• W2891937369 hasAuthorship W2891937369A5072098713 @default.
• W2891937369 hasBestOaLocation W28919373691 @default.
• W2891937369 hasConcept C134018914 @default.
• W2891937369 hasConcept C160160445 @default.
• W2891937369 hasConcept C181199279 @default.
• W2891937369 hasConcept C185592680 @default.
• W2891937369 hasConcept C195475562 @default.
• W2891937369 hasConcept C2775838275 @default.
• W2891937369 hasConcept C2776151105 @default.
• W2891937369 hasConcept C2777318727 @default.
• W2891937369 hasConcept C2778004101 @default.
• W2891937369 hasConcept C2778401633 @default.
• W2891937369 hasConcept C2778606649 @default.
• W2891937369 hasConcept C2778979269 @default.
• W2891937369 hasConcept C2779429693 @default.
• W2891937369 hasConcept C2779679107 @default.
• W2891937369 hasConcept C43617362 @default.
• W2891937369 hasConcept C55493867 @default.
• W2891937369 hasConcept C556039675 @default.
• W2891937369 hasConcept C71924100 @default.
• W2891937369 hasConcept C86803240 @default.
• W2891937369 hasConcept C98274493 @default.
• W2891937369 hasConceptScore W2891937369C134018914 @default.
• W2891937369 hasConceptScore W2891937369C160160445 @default.
• W2891937369 hasConceptScore W2891937369C181199279 @default.
• W2891937369 hasConceptScore W2891937369C185592680 @default.

• next