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• W2891937604 abstract "Ovarian cancer is frequently diagnosed as peritoneal carcinomatosis. Unlike other tumor locations, the peritoneal cavity is commonly exposed to gut-breaching and ascending genital microorganisms and has a unique immune environment. IL-33 is a local cytokine that can activate innate and adaptive immunity. We studied the effectiveness of local IL-33 delivery in the treatment of cancer that has metastasized to the peritoneal cavity. Direct peritoneal administration of IL-33 delayed the progression of metastatic peritoneal cancer. Prolongation in survival was not associated with a direct effect of IL-33 on tumor cells, but with major changes in the immune microenvironment of the tumor. IL-33 promoted a significant increase in the leukocyte compartment of the tumor immunoenvironment and an allergic cytokine profile. We observed a substantial increase in the number of activated CD4+ T-cells accompanied by peritoneal eosinophil infiltration, B-cell activation and activation of peritoneal macrophages which displayed tumoricidal capacity. Depletion of CD4+ cells, eosinophils or macrophages reduced the anti-tumor effects of IL-33 but none of these alone were sufficient to completely abrogate its positive benefit. In conclusion, local administration of IL-33 generates an allergic tumor environment resulting in a novel approach for treatment of metastatic peritoneal malignancies, such as advanced ovarian cancer." @default.
• W2891937604 created "2018-09-27" @default.
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• W2891937604 date "2018-09-06" @default.
• W2891937604 modified "2023-10-15" @default.
• W2891937604 title "IL-33 delays metastatic peritoneal cancer progression inducing an allergic microenvironment" @default.
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• W2891937604 doi "https://doi.org/10.1080/2162402x.2018.1515058" @default.
• W2891937604 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6287802" @default.
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