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- W2891939073 abstract "In recent years, targeted therapy and immunotherapy have played important roles in the treatment of patients with non-small-cell lung cancer (NSCLC). Drugs that target epidermal growth factor receptor (EGFR) mutations (eg, gefitinib, erlotinib, icotinib, and osimertinib) are among the most commonly used targeted therapies. Afatinib is an irreversible second-generation EGFR-tyrosine kinase inhibitor (EGFR-TKI), and the LUX-Lung 3 trial demonstrated the superiority of afatinib to cisplatin and pemetrexed in the frontline treatment of treatment-naïve patients with advanced EGFR mutation adenocarcinoma of the lung. Although these drugs show significant therapeutic efficacy, most patients invariably experience disease progression resulting in death. Immunotherapy targeting programmed death-1 (PD-1)/programmed death-ligand 1 (PD-L1) has now been approved for the first-line treatment of patients with advanced NSCLC. These can produce sustained clinical responses by reversing negative regulators of T-cell function; however, immunotherapy response rates remain low, and only a few patients ultimately benefit from this approach. Here, we discuss the potential of EGFR-TKIs for inducing antitumor immunity and the feasibility of their combination with immunotherapy (including PD-1/PD-L1 inhibitors) in NSCLC patients and the associated challenges for clinical application." @default.
- W2891939073 created "2018-09-27" @default.
- W2891939073 creator A5004349988 @default.
- W2891939073 creator A5009911740 @default.
- W2891939073 creator A5043365458 @default.
- W2891939073 date "2018-09-01" @default.
- W2891939073 modified "2023-10-16" @default.
- W2891939073 title "Immunotherapy combined with epidermal growth factor receptor-tyrosine kinase inhibitors in non-small-cell lung cancer treatment" @default.
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- W2891939073 doi "https://doi.org/10.2147/ott.s178497" @default.
- W2891939073 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6163004" @default.
- W2891939073 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30288054" @default.
- W2891939073 hasPublicationYear "2018" @default.
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