FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891939766> ?p ?o ?g. }

• W2891939766 endingPage "324" @default.
• W2891939766 startingPage "318" @default.
• W2891939766 abstract "Abstract Psychoactive substances of the 2C‐series (2Cs) are phenethylamine‐derived designer drugs that can induce psychostimulant and hallucinogenic effects. Chemically, the classic 2Cs contain two methoxy groups in positions 2 and 5 of the phenyl ring, whereas substances of the so‐called FLY series contain rigidified methoxy groups integrated in a 2,3,6,7‐tetrahydrobenzo[1,2‐b:4,5‐b’]difuran core. One of the pharmacological features that has not been investigated in detail is the inhibition of monoamine oxidase (MAO). Inhibition of this enzyme can cause elevated monoamine levels that have been associated with adverse events such as agitation, nausea, vomiting, tachycardia, hypertension, or seizures. The aim of this study was to extend the knowledge surrounding the potential of MAO inhibition for 17 test drugs, which consisted of 12 2Cs (2C‐B, 2C‐D, 2C‐E, 2C‐H, 2C‐I, 2C‐N, 2C‐P, 2C‐T‐2, 2C‐T‐7, 2C‐T‐21, bk‐2C‐B, and bk‐2C‐I) and five FLY analogs (2C‐B‐FLY, 2C‐E‐FLY, 2C‐EF‐FLY, 2C‐I‐FLY, and 2C‐T‐7‐FLY). The extent of MAO inhibition was assessed using an established in vitro procedure based on heterologously expressed enzymes and analysis by hydrophilic interaction liquid chromatography–high resolution tandem mass spectrometry. Thirteen test drugs showed inhibition potential for MAO‐A and 11 showed inhibition of MAO‐B. In cases where MAO‐A IC 50 values were determined, values ranged from 10 to 125 μM (7 drugs) and from 1.7 to 180 μM for MAO‐B (9 drugs). In the absence of detailed clinical information on most test drugs, it is concluded that a pharmacological contribution of MAO inhibition cannot be excluded and that further studies are warranted." @default.
• W2891939766 created "2018-09-27" @default.
• W2891939766 creator A5005457342 @default.
• W2891939766 creator A5005967499 @default.
• W2891939766 creator A5006156563 @default.
• W2891939766 creator A5006602823 @default.
• W2891939766 creator A5078935928 @default.
• W2891939766 date "2018-09-28" @default.
• W2891939766 modified "2023-09-25" @default.
• W2891939766 title "Interactions of phenethylamine-derived psychoactive substances of the 2C-series with human monoamine oxidases" @default.
• W2891939766 cites W1175366871 @default.
• W2891939766 cites W1558345946 @default.
• W2891939766 cites W1597304195 @default.
• W2891939766 cites W1958575417 @default.
• W2891939766 cites W1989176947 @default.
• W2891939766 cites W1996940919 @default.
• W2891939766 cites W1998621094 @default.
• W2891939766 cites W2033952955 @default.
• W2891939766 cites W2034729867 @default.
• W2891939766 cites W2047829360 @default.
• W2891939766 cites W2048561267 @default.
• W2891939766 cites W2056758002 @default.
• W2891939766 cites W2064797135 @default.
• W2891939766 cites W2116793633 @default.
• W2891939766 cites W2131341449 @default.
• W2891939766 cites W2153141793 @default.
• W2891939766 cites W2162926433 @default.
• W2891939766 cites W2165450714 @default.
• W2891939766 cites W2522590875 @default.
• W2891939766 cites W2528846765 @default.
• W2891939766 cites W2559628863 @default.
• W2891939766 cites W2596728500 @default.
• W2891939766 cites W2605119646 @default.
• W2891939766 cites W2608262290 @default.
• W2891939766 cites W2703639613 @default.
• W2891939766 cites W2783588885 @default.
• W2891939766 cites W2786430007 @default.
• W2891939766 cites W2797645136 @default.
• W2891939766 doi "https://doi.org/10.1002/dta.2494" @default.
• W2891939766 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30188017" @default.
• W2891939766 hasPublicationYear "2018" @default.
• W2891939766 type Work @default.
• W2891939766 sameAs 2891939766 @default.
• W2891939766 citedByCount "12" @default.
• W2891939766 countsByYear W28919397662019 @default.
• W2891939766 countsByYear W28919397662020 @default.
• W2891939766 countsByYear W28919397662021 @default.
• W2891939766 countsByYear W28919397662022 @default.
• W2891939766 countsByYear W28919397662023 @default.
• W2891939766 crossrefType "journal-article" @default.
• W2891939766 hasAuthorship W2891939766A5005457342 @default.
• W2891939766 hasAuthorship W2891939766A5005967499 @default.
• W2891939766 hasAuthorship W2891939766A5006156563 @default.
• W2891939766 hasAuthorship W2891939766A5006602823 @default.
• W2891939766 hasAuthorship W2891939766A5078935928 @default.
• W2891939766 hasBestOaLocation W28919397662 @default.
• W2891939766 hasConcept C114461151 @default.
• W2891939766 hasConcept C170493617 @default.
• W2891939766 hasConcept C181199279 @default.
• W2891939766 hasConcept C185592680 @default.
• W2891939766 hasConcept C187714386 @default.
• W2891939766 hasConcept C2775864247 @default.
• W2891939766 hasConcept C2776024655 @default.
• W2891939766 hasConcept C2780047746 @default.
• W2891939766 hasConcept C39398028 @default.
• W2891939766 hasConcept C55493867 @default.
• W2891939766 hasConcept C71240020 @default.
• W2891939766 hasConcept C71924100 @default.
• W2891939766 hasConcept C98274493 @default.
• W2891939766 hasConceptScore W2891939766C114461151 @default.
• W2891939766 hasConceptScore W2891939766C170493617 @default.
• W2891939766 hasConceptScore W2891939766C181199279 @default.
• W2891939766 hasConceptScore W2891939766C185592680 @default.
• W2891939766 hasConceptScore W2891939766C187714386 @default.
• W2891939766 hasConceptScore W2891939766C2775864247 @default.
• W2891939766 hasConceptScore W2891939766C2776024655 @default.
• W2891939766 hasConceptScore W2891939766C2780047746 @default.
• W2891939766 hasConceptScore W2891939766C39398028 @default.
• W2891939766 hasConceptScore W2891939766C55493867 @default.
• W2891939766 hasConceptScore W2891939766C71240020 @default.
• W2891939766 hasConceptScore W2891939766C71924100 @default.
• W2891939766 hasConceptScore W2891939766C98274493 @default.
• W2891939766 hasIssue "2" @default.
• W2891939766 hasLocation W28919397661 @default.
• W2891939766 hasLocation W28919397662 @default.
• W2891939766 hasLocation W28919397663 @default.
• W2891939766 hasLocation W28919397664 @default.
• W2891939766 hasOpenAccess W2891939766 @default.
• W2891939766 hasPrimaryLocation W28919397661 @default.
• W2891939766 hasRelatedWork W1965425376 @default.
• W2891939766 hasRelatedWork W1965970511 @default.
• W2891939766 hasRelatedWork W1984067955 @default.
• W2891939766 hasRelatedWork W2021713017 @default.
• W2891939766 hasRelatedWork W2073392453 @default.
• W2891939766 hasRelatedWork W2086279556 @default.
• W2891939766 hasRelatedWork W2090114150 @default.
• W2891939766 hasRelatedWork W2133522248 @default.
• W2891939766 hasRelatedWork W2394490534 @default.

• next