FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891941954> ?p ?o ?g. }

• W2891941954 abstract "Background ANCA-associated vasculitis [AAV] is a small-medium vessel vasculitis that presents in a multi-systemic fashion, and is associated with significant mortality. Outcomes have improved with the introduction of immunosuppressive medications [ISM], the evidence supporting the initial choice ISM in AAV is limited, and may be influenced by health disparities related to social factors. Objectives The objective of this study was to compare various factors known to influence management and outcomes in AAV. Factors including, patient demographics, socioeconomics, clinical presentations, and medication choices were reviewed in relation to outcomes within the cohort. Methods This was a retrospective, single centre, hospital-affiliated cohort study. A list of all patients seen by the Rheumatology service between 2011 and 2016 with a diagnosis of AAV was generated. A review of the 3000 charts confirmed 77 patients that met the 1990 American College of Rheumatology criteria for AAV. General demographic data including age, gender, zip code, and median household income as well as disease related data including serology, disease manifestation, and treatment were obtained through a chart review and recorded in the database. Supplemental socioeconomic information for each patient zip code was obtained from the United States Government Census website. Results In our cohort the anti-proteinase 3 [PR3] antibody was the most common positive antibody. There was a relationship between PR3 antibody positivity rate and body mass index [table 1]. Given the low number of non-Caucasians we were unable to comment on the relationship between antibody and race. Medication choice and mortality were independent of mean household income. Rituximab was the most commonly prescribed ISM [44%]. The median age of rituximab exposure patients was 65 years and 60 years for unexposed patents. There was no significant relationship between age and medication choice. Rituximab was prescribed 60% of the time in renal AAV [p The overall mortality rate was 17% [13/75] [figure 1]. There was no significant difference in the mortality rate of patients 65 years and older [23%, 9/39] compared to patients 64 and younger [11%, 4/36; p=0.17]. The mortality rate was also independent of median household income. Conclusions There was no relationship between age, sex, income, immunosuppressive therapy, and mortality in our AAV cohort. The mortality rate was higher in more severe disease and rituximab was more commonly used in such cases as well as in older patients. The limitations of the study include this being a hospital based cohort, where social demographics may have less of an impact. There was a lack of racial diversity, though the cohort did reflect the general demographics in southwest Virginia. Disclosure of Interest None declared" @default.
• W2891941954 created "2018-09-27" @default.
• W2891941954 creator A5028918952 @default.
• W2891941954 creator A5056944290 @default.
• W2891941954 creator A5069169524 @default.
• W2891941954 creator A5076135388 @default.
• W2891941954 date "2018-06-01" @default.
• W2891941954 modified "2023-09-26" @default.
• W2891941954 title "AB0645 Anca vasculitis: the experience and trends in patient care from a single centre" @default.
• W2891941954 doi "https://doi.org/10.1136/annrheumdis-2018-eular.1738" @default.
• W2891941954 hasPublicationYear "2018" @default.
• W2891941954 type Work @default.
• W2891941954 sameAs 2891941954 @default.
• W2891941954 citedByCount "0" @default.
• W2891941954 crossrefType "proceedings-article" @default.
• W2891941954 hasAuthorship W2891941954A5028918952 @default.
• W2891941954 hasAuthorship W2891941954A5056944290 @default.
• W2891941954 hasAuthorship W2891941954A5069169524 @default.
• W2891941954 hasAuthorship W2891941954A5076135388 @default.
• W2891941954 hasBestOaLocation W28919419541 @default.
• W2891941954 hasConcept C126322002 @default.
• W2891941954 hasConcept C147077947 @default.
• W2891941954 hasConcept C167135981 @default.
• W2891941954 hasConcept C198451711 @default.
• W2891941954 hasConcept C2776015282 @default.
• W2891941954 hasConcept C2779134260 @default.
• W2891941954 hasConcept C2908647359 @default.
• W2891941954 hasConcept C71924100 @default.
• W2891941954 hasConcept C72563966 @default.
• W2891941954 hasConcept C99454951 @default.
• W2891941954 hasConceptScore W2891941954C126322002 @default.
• W2891941954 hasConceptScore W2891941954C147077947 @default.
• W2891941954 hasConceptScore W2891941954C167135981 @default.
• W2891941954 hasConceptScore W2891941954C198451711 @default.
• W2891941954 hasConceptScore W2891941954C2776015282 @default.
• W2891941954 hasConceptScore W2891941954C2779134260 @default.
• W2891941954 hasConceptScore W2891941954C2908647359 @default.
• W2891941954 hasConceptScore W2891941954C71924100 @default.
• W2891941954 hasConceptScore W2891941954C72563966 @default.
• W2891941954 hasConceptScore W2891941954C99454951 @default.
• W2891941954 hasLocation W28919419541 @default.
• W2891941954 hasOpenAccess W2891941954 @default.
• W2891941954 hasPrimaryLocation W28919419541 @default.
• W2891941954 hasRelatedWork W2325909579 @default.
• W2891941954 hasRelatedWork W2419163947 @default.
• W2891941954 hasRelatedWork W2520180490 @default.
• W2891941954 hasRelatedWork W2551930302 @default.
• W2891941954 hasRelatedWork W2559459088 @default.
• W2891941954 hasRelatedWork W2744016857 @default.
• W2891941954 hasRelatedWork W2749772652 @default.
• W2891941954 hasRelatedWork W2886206709 @default.
• W2891941954 hasRelatedWork W2906043785 @default.
• W2891941954 hasRelatedWork W2942372120 @default.
• W2891941954 hasRelatedWork W2951060310 @default.
• W2891941954 hasRelatedWork W2980315876 @default.
• W2891941954 hasRelatedWork W3035021685 @default.
• W2891941954 hasRelatedWork W3092808894 @default.
• W2891941954 hasRelatedWork W3096246918 @default.
• W2891941954 hasRelatedWork W3110976525 @default.
• W2891941954 hasRelatedWork W3120789430 @default.
• W2891941954 hasRelatedWork W3164341904 @default.
• W2891941954 hasRelatedWork W3175556681 @default.
• W2891941954 hasRelatedWork W3207479392 @default.
• W2891941954 isParatext "false" @default.
• W2891941954 isRetracted "false" @default.
• W2891941954 magId "2891941954" @default.
• W2891941954 workType "article" @default.